scholarly journals Bone morphogenic proteins in iron homeostasis

Bone ◽  
2020 ◽  
Vol 138 ◽  
pp. 115495 ◽  
Author(s):  
Xia Xiao ◽  
Víctor M. Alfaro-Magallanes ◽  
Jodie L. Babitt
Keyword(s):  
Iron Homeostasis ◽  
Bone Morphogenic Proteins

Processing of Hemojuvelin Requires Retrograde Trafficking to the Golgi in HepG2 Cells.

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 3845-3845
Author(s):  
An-Sheng Zhang ◽  
Julia Julia Maxson ◽  
Caroline A Enns
Keyword(s):  
Plasma Membrane ◽  
Cell Surface ◽  
Hepg2 Cells ◽  
Iron Homeostasis ◽  
Bmp Signaling ◽  
Soluble Form ◽  
Gpi Anchor ◽  
Retrograde Trafficking ◽  
Hepcidin Expression ◽  
Bone Morphogenic Proteins

Abstract Hemojuvelin (HJV) was recently identified as a critical regulator of iron homeostasis. It is either associated with the cells through a GPI-anchor or released as a soluble form. The cellular form acts as a co-receptor for bone morphogenic proteins (BMPs) and activates the transcription of hepcidin, a hormone that regulates iron efflux from cells. Soluble HJV antagonizes BMP signaling and suppresses hepcidin expression. Secretion of HJV requires binding to the transmembrane receptor neogenin. In this study we examined the trafficking and processing of HJV. Cellular HJV reached the plasma membrane without obtaining complex oligosaccharides, indicating that HJV avoided Golgi processing. Secreted HJV, in contrast, had complex oligosaccharides and could be derived from the pool of HJV at the plasma membrane. Neogenin did not play a role in HJV trafficking to the cell surface but was necessary for secretion of HJV, suggesting that it could be involved in either retrograde trafficking of HJV or in cleavage leading to secretion.

Age and gender dependent differences in BMP6 mediated hepcidin expression and iron homeostasis

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
S Arndt ◽  
U Mägdefrau ◽  
C Dorn ◽  
K Schardt ◽  
C Hellerbrand ◽  
...  
Keyword(s):  
Iron Homeostasis ◽  
Age And Gender ◽  
Hepcidin Expression ◽  
And Gender

Meeting Report: Intestinal BMP6, a Master Gene for the Regulation of Iron Homeostasis

2011 ◽  
Vol 49 (10) ◽  
Author(s):  
Stephanie Arndt ◽  
Ulrike Maegdefrau ◽  
Christoph Dorn ◽  
Katharina Schardt ◽  
Claus Hellerbrand ◽  
...  
Keyword(s):  
Iron Homeostasis ◽  
Meeting Report

Defect Repair in the Rat Mandible With Bone Morphogenic Proteins and Marrow Cells

2003 ◽  
Vol 5 (1) ◽  
pp. 103-108 ◽  
Author(s):  
Oneida A. Arosarena ◽  
Arthur Falk ◽  
Leslie Malmgren ◽  
Linda Bookman ◽  
Matthew J. Allen ◽  
...  
Keyword(s):  
Bone Morphogenic Proteins ◽  
Defect Repair ◽  
Rat Mandible ◽  
Marrow Cells

In vivo Experiments of Natural Products Protection of Antagonistic Effects of Lead on Iron

2018 ◽  
Vol 68 (12) ◽  
pp. 2747-2751
Author(s):  
Marioara Nicula ◽  
Nicolae Pacala ◽  
Lavinia Stef ◽  
Ioan Pet ◽  
Dorel Dronca ◽  
...  
Keyword(s):  
Aquatic Environment ◽  
Iron Homeostasis ◽  
Iron Concentration ◽  
Antagonistic Effect ◽  
Tissue Samples ◽  
Antagonistic Effects ◽  
In Vivo Experiments ◽  
Living Organisms ◽  
Toxic Potential

Living organisms take nutrients from the environment, and together with them, substances with toxic potential � such as heavy metals. Lead is one common metal pollutant especially in aquatic environment, from where the fish can be intoxicated very easily. Bioavailability, distribution, toxic action, synergistic and antagonistic effects are characteristics which can alter the fish health. Our experimental study followed the effects of lead overload in water on iron distribution, in different tissues sample Carassius gibelio Bloch fish. We performed the experiment in four different fish groups: control C; lead � Pb (administration of lead in water 0.075mg/mL of water, as Pb(NO3)2 x � H2O); lead (the same dose) and 2% of freeze-dry garlic incorporated into fishes� food � Pb+garlic; lead (the same dose) and 2% chlorella incorporated into fishes� food � Pb+chlorella, for 21 consecutive days. The iron concentration was analysed with AAS (Atomic Absorption Spectroscopy) from gills, muscle, skin (and scales), intestine, liver, heart, brain, ovary, testicles, and kidney. The obtained data presented a significantly decrease of iron content in all tested tissue samples that demonstrated, alteration of iron homeostasis, explained by a strong antagonistic effect of lead on iron. Our experiment showed that biologic active principles from garlic and chlorella act like natural protectors, and potentiate the iron deficiency even in the case of lead overload in aquatic environment, for fish.

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