scholarly journals Spatial and biochemical interactions between bone marrow adipose tissue and hematopoietic stem and progenitor cells in rhesus macaques

Bone ◽  
2020 ◽  
Vol 133 ◽  
pp. 115248 ◽  
Author(s):  
Jacob J. Robino ◽  
Nathalie Pamir ◽  
Sara Rosario ◽  
Lindsey B. Crawford ◽  
Benjamin J. Burwitz ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Progenitor Cells ◽  
Rhesus Macaques ◽  
Hematopoietic Stem ◽  
Bone Marrow Adipose Tissue ◽  
Marrow Adipose Tissue ◽  
Stem And Progenitor Cells

scholarly journals Mechanism of Action of Diallyl Sulphide in Ameliorating the Hematopoietic Radiation Injury

2021 ◽  
Author(s):  
Omika Katoch ◽  
Mrinalini Tiwari ◽  
Namita Kalra ◽  
Paban K. Agrawala
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Progenitor Cells ◽  
Hematopoietic Stem ◽  
Proliferation And Differentiation ◽  
Stem And Progenitor Cells ◽  
Radiation Induced ◽  
Medicinal Properties ◽  
Marrow Cellularity

AbstractDiallyl sulphide (DAS), the pungent component of garlic, is known to have several medicinal properties and has recently been shown to have radiomitigative properties. The present study was performed to better understand its mode of action in rendering radiomitigation. Evaluation of the colonogenic ability of hematopoietic progenitor cells (HPCs) on methocult media, proliferation and differentiation of hematopoietic stem cells (HSCs), and transplantation of stem cells were performed. The supporting tissue of HSCs was also evaluated by examining the histology of bone marrow and in vitro colony-forming unit–fibroblast (CFU-F) count. Alterations in the levels of IL-5, IL-6 and COX-2 were studied as a function of radiation or DAS treatment. It was observed that an increase in proliferation and differentiation of hematopoietic stem and progenitor cells occurred by postirradiation DAS administration. It also resulted in increased circulating and bone marrow homing of transplanted stem cells. Enhancement in bone marrow cellularity, CFU-F count, and cytokine IL-5 level were also evident. All those actions of DAS that could possibly add to its radiomitigative potential and can be attributed to its HDAC inhibitory properties, as was observed by the reversal radiation induced increase in histone acetylation.

scholarly journals Captopril Inhibits the Proliferation of Hematopoietic Stem and Progenitor Cells in Murine Long‐Term Bone Marrow Cultures

Stem Cells ◽  
1999 ◽  
Vol 17 (6) ◽  
pp. 339-344 ◽  
Author(s):  
John Eugenes Chisi ◽  
Joanna Wdzieczak‐Bakala ◽  
Josiane Thierry ◽  
Cecile V. Briscoe ◽  
Andrew C. Riches
Keyword(s):  
Bone Marrow ◽  
Progenitor Cells ◽  
Hematopoietic Stem ◽  
Stem And Progenitor Cells ◽  
Bone Marrow Cultures ◽  
Marrow Cultures
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