Dual-energy estimates of volumetric bone mineral densities in the lumbar spine using quantitative computed tomography better correlate with fracture properties when compared to single-energy BMD outcomes

Bone ◽  
2020 ◽  
Vol 130 ◽  
pp. 115100 ◽  
Author(s):  
Simon Cataño Jimenez ◽  
Sebastian Saldarriaga ◽  
Christopher D. Chaput ◽  
Hugo Giambini
Keyword(s):  
Computed Tomography ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Quantitative Computed Tomography ◽  
Dual Energy ◽  
Energy Estimates ◽  
Fracture Properties

Effect of spinal degenerative changes on volumetric bone mineral density of the central skeleton as measured by quantitative computed tomography

2005 ◽  
Vol 46 (3) ◽  
pp. 269-275 ◽  
Author(s):  
G. Guglielmi ◽  
I. Floriani ◽  
V. Torri ◽  
J. Li ◽  
C. van Kuijk ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Vertebral Fractures ◽  
Quantitative Computed Tomography ◽  
Degenerative Changes ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
The Impact

Purpose: To evaluate the impact of degenerative changes due to osteoarthritis (OA) at the spine on volumetric bone mineral density (BMD) as measured by volumetric quantitative computed tomography (vQCT). Material and Methods: Eighty‐four elderly women (mean age 73±6 years), comprising 33 with vertebral fractures assessed by radiographs and 51 without vertebral fractures, were studied. Trabecular, cortical, and integral BMD were examined at the spine and hip using a helical CT scanner and were compared to dual X‐ray absorptiometry (DXA) measurements at the same sites. OA changes visible on the radiographs were categorized into two grades according to severity. Differences in BMD measures obtained in the two groups of patients defined by OA grade using the described radiologic methods were compared using analysis of variance. Standardized difference (effect sizes) was also compared between radiologic methods. Results: Spinal trabecular BMD did not differ significantly between OA grade 0 and OA grade 1. Spinal cortical and integral BMD measures showed statistically significant differences, as did the lumbar spine DXA BMD measurement (13%, P = 0.02). The QCT measurements at the hip were also higher in OA 1 subjects. Femoral trabecular BMD was 13–15% higher in OA grade 1 subjects than in OA grade 0 subjects. The cortical BMD measures in the CT_TOT_FEM and CT_TROCH ROI's were also higher in the OA 1 subjects. The integral QCT BMD measures in the hip showed difference between grades OA 1 and 0. The DXA measurements in the neck and trochanter ROI's showed smaller differences (9 and 11%, respectively). There were no statistically significant differences in bone size. Conclusion: There is no evidence supporting that trabecular BMD measurements by QCT are influenced by OA. Instead, degenerative changes have an effect on both cortical and integral QCT, and on DXA at the lumbar spine and the hip. For subjects with established OA, assessment of BMD by volumetric QCT may be suggested.

Vertebral Bone Mineral Measurement Using Dual Photon Absorptiometry and Computed Tomography

1988 ◽  
Vol 29 (1) ◽  
pp. 89-94 ◽  
Author(s):  
S. Eriksson ◽  
B. Isberg ◽  
U. Lindgren
Keyword(s):  
Computed Tomography ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Vertebral Body ◽  
Dual Energy ◽  
Dual Photon Absorptiometry ◽  
Mineral Density ◽  
Photon Absorptiometry ◽  
The Mean ◽  
Posterior Elements

The lumbar spine of 14 cadavers was studied both by 153Gd dual photon absorptiometry (DPA) and quantitative computed tomography (QCT) at 96 and 125 kVp. The intact spine and the individual vertebrae were analyzed. After these measurements the ash content of the vertebral body, the posterior elements, and the transverse processes was determined. The fat content of the vertebral body as well as its volume was also measured. With DPA, the bone mineral content (BMC) determined in situ as well as on excised spine specimens correlated highly with the amount of total vertebral ash (r>0.92, SEE<3.2 g). The bone mineral density (BMD, area density) of 3 lumbar vertebrae correlated accurately with the mean ash density of the vertebral body (r>0.81, SEE<0.015 g/cm3). The so-called corpus density and central density determinations were less accurate. No difference in accuracy was found between measurements when using 3 mm and 4.5 mm step intervals. Variations in the distribution of mineral between the vertebral body and the posterior elements contribute to the error in predicting vertebral body mineral with DPA. QCT gave a smaller error when a cylindric portion of the vertebral body with a 20 mm diameter was measured compared with one with a 9 mm diameter, when the dual energy technique was used (p<0.01). With dual energy QCT a correlation was found between a center segment of 3 vertebrae in the lumbar spine and the mean ash density of the vertebral body of r=0.92 (SEE=0.010 g/cm3). Single energy QCT was insignificantly less accurate than dual energy QCT. Only small differences were found between vertebrae with high fat density of the vertebral body when single or dual QCT was used. QCT was more accurate than DPA in the prediction of the mineral density of individual vertebral bodies (p<0.05) but no difference was found when the average values for the lumbar spine were calculated.

scholarly journals Modern approaches and possibilities for assessing bone mineral density by quantitative computed tomography (literature review)

2021 ◽  
Vol 23 (4) ◽  
pp. 372-381
Author(s):  
Aleksandr A. Melnikov ◽  
◽  
Viktor V. Diachenko ◽  
Igor V. Shubin ◽  
Aleksei E. Nikitin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Mineral Density ◽  
Bone Mineral ◽  
Imaging Techniques ◽  
Quantitative Computed Tomography ◽  
Dual Energy ◽  
Mineral Density ◽  
Diagnosis Of Osteoporosis ◽  
X Ray ◽  
Clinically Significant

The review provides the literature data on the basal issues of bone remodeling and the applied use of medical imaging techniques for the prevention of clinically significant consequences of osteoporosis. The article discusses the role and prospects of using the method of quantitative computed tomography and its modifications for the diagnosis of osteoporosis and osteopenic syndrome. It considers the advantages of quantitative computed tomography over widely used medical techniques for assessing bone mineral density (mono- and dual-energy X-ray absorptiometry, mono- and dual-energy isotope absorptiometry).

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