scholarly journals Development and characterization of supramolecular calcitonin assembly and assessment of its interactions with the bone remodelling process

Bone ◽  
2019 ◽  
Vol 122 ◽  
pp. 123-135 ◽  
Author(s):  
Kapil Manglani ◽  
Viji Vijayan ◽  
Chandramani Pathak ◽  
Mayuri Khandelwal ◽  
Parminder Singh ◽  
...  
Keyword(s):  
Bone Remodelling ◽  
Bone Remodelling Process

MicroRNA-548-3p overexpression inhibits proliferation, migration and invasion in osteoblast-like cells by targeting STAT1 and MAFB

2020 ◽  
Vol 168 (3) ◽  
pp. 203-211 ◽  
Author(s):  
Eric G Ramírez-Salazar ◽  
Erika V Almeraya ◽  
Tania V López-Perez ◽  
Nelly Patiño ◽  
Jorge Salmeron ◽  
...  
Keyword(s):  
Cell Lines ◽  
Target Genes ◽  
Bone Remodelling ◽  
Functional Characterization ◽  
Migration And Invasion ◽  
Public Health Issue ◽  
Bone Remodelling Process ◽  
First Time

Abstract Osteoporosis is the most common bone disease and a public health issue with increasing prevalence in Mexico. This disease is caused by an imbalance in the bone remodelling process mediated by osteoclast and osteoblast. MicroRNAs have emerged as key players during the differentiation of both types of cells specialized involved in bone metabolism. We found high expression levels of miR-548x-3p in circulating monocytes derived from postmenopausal osteoporotic women. This study aimed to analyse the functional characterization of miR-548x-3p roles in the bone remodelling process. We validated by RT-qPCR, the elevated levels of miR-548x-3p in circulating monocytes derived from osteoporosis women. Through bioinformatics analysis, we identify MAFB and STAT1 as potential target genes for miR-548x-3p. Both genes showed low levels of expression in circulating monocytes derived from osteoporotic women. In addition, we demonstrated the binding of miR-548x-3p to the 3′-UTR of both mRNAs. MiR-548x-3p was overexpressed in osteoblasts-like cell lines decreasing the levels of MAFB and STAT1 mRNA and protein. We found that miR-548x-3p overexpression inhibits the proliferation, migration and invasion of the cell lines evaluated. Our results identified, by the first time, the potential role of miR-548x-3p as a modulator of the bone remodelling process by regulating the expression of MAFB and STAT1.

Clinical Efficacy of Bone Reconstruction Surgery with Frozen Cortical Bone Allografts for Nonunion of Radial and Ulnar Fractures in Toy Breed Dogs

2018 ◽  
Vol 31 (03) ◽  
pp. 159-169
Author(s):  
Yukari Nagahiro ◽  
Daichi Katori ◽  
Norihiro Muroi ◽  
Hiroyuki Akagi ◽  
Nobuo Kanno ◽  
...  
Keyword(s):  
Cortical Bone ◽  
Bone Remodelling ◽  
Weight Bearing ◽  
Healing Process ◽  
Bone Reconstruction ◽  
Bone Allografts ◽  
Bone Remodelling Process ◽  
Large Bone ◽  
Atrophic Nonunion ◽  
Large Bone Defects

Objective To evaluate the effectiveness of frozen cortical bone allografts (FCBA) in the treatment of severe radial and ulnar atrophic nonunion fractures. Animals Toy breed dogs with nonunion of radial and ulnar fractures (n = 15). Methods Severe atrophic nonunion fractures were treated with FCBA (eight infected and seven non-infected fractures). Radiographs obtained immediately after surgery, and 1, 2, 3, 6 and 12 months later were evaluated and scored for the periosteal reaction at the bone regeneration sites, the healing process in the bone connection areas at both the proximal and distal sites, and the bone remodelling process within the allografts. Results Improvements in the fracture-healing process and weight-bearing function were observed in all cases. Radiographic scores at the bone connection areas and within the allograft improved significantly over time (p < 0.05). There were not any significant differences in radiographic scores between the infected and non-infected groups. Clinical Significance Bone reconstruction with FCBA is effective in the treatment of radial and ulnar nonunion fractures associated with large bone defects, regardless of the infection status of the surgical site.

Polyphenol-Rich Foods and Osteoporosis

2019 ◽  
Vol 25 (22) ◽  
pp. 2459-2466 ◽  
Author(s):  
Emanuele Chisari ◽  
Nitin Shivappa ◽  
Shraddha Vyas
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Dietary Intervention ◽  
Bone Cells ◽  
Bone Remodelling ◽  
Free Radical Scavengers ◽  
Current Evidence ◽  
Osteoporosis Prevention ◽  
Mineral Density ◽  
Bone Remodelling Process

Background: Osteoporosis is a metabolic disease affecting the bone mineral density and thus compromise the strength of the bones. Disease prevention through diet is the objective of the study and discussion. Among the several nutrients investigated, the intake of phenols seems to influence bone mineral density by acting as free radical scavengers, preventing oxidation-induced damage to bone cells. In addition, the growing understanding of the bone remodelling process supports the theory that inflammation significantly contributes to the etiopathogenesis of osteoporosis. Methods: To provide an overview of current evidence on polyphenol-rich foods and osteoporosis prevention we made a comprehensive review of the literature focusing on the state of art of the topic. Results: Some polyphenol-rich foods, including olive oil, fruit and vegetable, tea and soy, seem to be beneficial for preventing osteoporosis disease and its progression. The mechanism is still partly unknown and may involve different pathways which include inflammation and other disease reactions. Conclusion: However, further research is needed to better understand the mechanisms regulating the molecular interaction between osteoporosis incidence and progression and polyphenol-rich foods. The current evidence suggests that dietary intervention with polyphenol rich foods may be useful to prevent incidence and progression of this condition.

scholarly journals How Cells Communicate in the Bone Remodelling Process

2010 ◽  
Vol 25 (1) ◽  
pp. 1 ◽  
Author(s):  
Thomas J. Martin ◽  
Natalie A. Sims
Keyword(s):  
Bone Remodelling ◽  
Bone Remodelling Process

scholarly journals Characterization of a new fish-derived bioactive neuropeptide involved in bone remodelling. Its physiological function and therapeutic potential.

2014 ◽  
Vol 1 ◽  
Author(s):  
Suarez-Bregua Paula ◽  
Torres-Nuñez Eva ◽  
Prober David ◽  
Cerdá-Reverter José Miguel ◽  
Guerreiro Pedro ◽  
...  
Keyword(s):  
Bone Remodelling ◽  
Physiological Function ◽  
Therapeutic Potential

scholarly journals Microextensometry and mechanical behaviour of Haversian cortical bone

2009 ◽  
pp. 93-104
Author(s):  
Laurent Henry ◽  
Thierry Hoc ◽  
Elisa Budyn
Keyword(s):  
Finite Elements ◽  
Mechanical Behaviour ◽  
Mineral Content ◽  
Bone Remodelling ◽  
Bone Microarchitecture ◽  
Local Strains ◽  
Inverse Approach ◽  
Bone Remodelling Process ◽  
Experimental Strain ◽  
The Relationship

It is well known that bone microarchitecture is mainly the result of the bone remodelling process. However, a mechanistic framework describing how the microstructure affects the mechanical behaviour of bone is still lacking. Therefore, tools to quantify bone quality at the microstructure scale are required. To address this problem, the present study focused on the measurements of the local strains over a large microstructure area using microextensometry. First, the relationship between the local strains and the mineral content was examined. Then, the local strains were used to feed an inverse approach performed by finite elements. The results show there is no correlation between the strain and the mineral content. Moreover, the implementation of the mineral content in finite elements simulations gave a better estimate of the experimental strain field.

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