scholarly journals Weekly teriparatide treatment increases vertebral body strength by improving cortical shell architecture in ovariectomized cynomolgus monkeys

Bone ◽  
2019 ◽  
Vol 121 ◽  
pp. 80-88 ◽  
Author(s):  
Ryuji Fujihara ◽  
Tasuku Mashiba ◽  
Shingo Yoshitake ◽  
Satoshi Komatsubara ◽  
Ken Iwata ◽  
...  
Keyword(s):  
Vertebral Body ◽  
Cynomolgus Monkeys ◽  
Teriparatide Treatment ◽  
Body Strength ◽  
Cortical Shell

scholarly journals Improvements in Vertebral Body Strength Under Teriparatide Treatment Assessed In Vivo by Finite Element Analysis: Results From the EUROFORS Study

2009 ◽  
Vol 24 (10) ◽  
pp. 1672-1680 ◽  
Author(s):  
Christian Graeff ◽  
Yan Chevalier ◽  
Mathieu Charlebois ◽  
Peter Varga ◽  
Dieter Pahr ◽  
...  
Keyword(s):  
Finite Element Analysis ◽  
Finite Element ◽  
Vertebral Body ◽  
Element Analysis ◽  
Teriparatide Treatment ◽  
Body Strength

Effect of the Pedicle and Posterior Arch on Vertebral Body Strength Predictions in Finite Element Modeling

Spine ◽  
1998 ◽  
Vol 23 (8) ◽  
pp. 899-907 ◽  
Author(s):  
Cari M. Whyne ◽  
Serena S. Hu ◽  
Stephen Klisch ◽  
Jeffrey C. Lotz
Keyword(s):  
Finite Element ◽  
Finite Element Modeling ◽  
Vertebral Body ◽  
Posterior Arch ◽  
Element Modeling ◽  
Body Strength

scholarly journals The Finite Element Analysis of Osteoporotic Lumbar Vertebral Body by Influence of Trabecular Bone Apparent Density and Thickness of Cortical Shell

2017 ◽  
Vol 11 (4) ◽  
pp. 285-292 ◽  
Author(s):  
Oleg Ardatov ◽  
Algirdas Maknickas ◽  
Vidmantas Alekna ◽  
Marija Tamulaitienė ◽  
Rimantas Kačianauskas
Keyword(s):  
Vertebral Body ◽  
Cancellous Bone ◽  
Apparent Density ◽  
Yield Criterion ◽  
Nonlinear Dynamic Analysis ◽  
Lumbar Vertebrae ◽  
Element Analysis ◽  
Bone Mass Loss ◽  
Lumbar Vertebral Body ◽  
Cortical Shell

AbstractOsteoporosis causes the bone mass loss and increased fracture risk. This paper presents the modelling of osteoporotic human lumbar vertebrae L1 by employing finite elements method (FEM). The isolated inhomogeneous vertebral body is composed by cortical out-er shell and cancellous bone. The level of osteoporotic contribution is characterised by reducing the thickness of cortical shell and elasticity modulus of cancellous bone using power-law dependence with apparent density. The strength parameters are evaluated on the basis of von Mises-Hencky yield criterion. Parametric study of osteoporotic degradation contains the static and nonlinear dynamic analysis of stresses that occur due to physiological load. Results of our investigation are presented in terms of nonlinear interdependence between stress and external load.

Effect of loading rate on endplate and vertebral body strength in human lumbar vertebrae

2003 ◽  
Vol 36 (12) ◽  
pp. 1875-1881 ◽  
Author(s):  
Ruth S Ochia ◽  
Allan F Tencer ◽  
Randal P Ching
Keyword(s):  
Vertebral Body ◽  
Loading Rate ◽  
Lumbar Vertebrae ◽  
Body Strength

P11. The role of the LRP5 gene in vertebral body strength

2005 ◽  
Vol 5 (4) ◽  
pp. S114-S115
Author(s):  
Kimihiko Sawakami ◽  
Alexander G. Robling ◽  
Minrong Ai ◽  
Matthew L. Warman ◽  
Charles H. Turner
Keyword(s):  
Vertebral Body ◽  
Body Strength

Role of Vertebral Shell and Endplate Modulus on Whole Vertebral Body Stiffness

1999 ◽  
Author(s):  
Michael A. K. Liebschner ◽  
David L. Kopperdahl ◽  
Tony M. Keaveny
Keyword(s):  
Computed Tomography ◽  
Cortical Bone ◽  
Vertebral Body ◽  
Fracture Strength ◽  
Shell Thickness ◽  
Bone Geometry ◽  
Image Resolution ◽  
Cortical Shell ◽  
Cortical Bone Geometry

Abstract The contribution of the cortical shell and endplate to the stiffness and strength of the vertebral body is not well understood. However, several studies have suggested that the cortical shell plays an important role in the fracture strength of the whole vertebral body as bone is progressively lost from the centrum due to aging and osteoporosis (Eastell 1991, Faulkner 1991, Kurowski 1986. Silva 1997). Silva et al. (1994) concluded that prediction of cortical bone geometry using computed tomography (CT) based measurements is subject to considerable uncertainly caused by image distortion and the low ratio of image resolution of 0.25 mm/pixel to cortical shell thickness (0.09–0.86 mm). Thus, in development of CT-based models of the vertebral body, particular attention should be paid to the details of shell modeling.

QCT Cortical Shell Thickness as a Predictor of Vertebral Body Strength for Cynomolgus Monkeys

1999 ◽  
Author(s):  
Clark R. Dickerson ◽  
Subrata Saha ◽  
Charlotte Hotchkiss
Keyword(s):  
Cortical Thickness ◽  
Maximum Stress ◽  
Lumbar Vertebrae ◽  
Cortical Region ◽  
Load Carrying Capacity ◽  
Vertebral Strength ◽  
Body Strength ◽  
Load Carrying ◽  
Cortical Shell ◽  
Vertebral Bodies

Abstract Many studies have investigated the ability of vertebral trabecular BMC measurements to predict overall vertebral strength. Far fewer investigations, however, have examined the use of cortical shell data to predict maximum strength. In this study, we are investigating the load-carrying characteristics of the cortical region of vertebral bodies Lumbar vertebrae from macaca fascicularis were examined by QCT and mechanically tested in compression. Our results show that cortical thickness, as determined by QCT, is a significant predictor of vertebral maximum stress (R = 0.62, p < 1 E−5). This relationship is improved when the cortical thickness is compared to load (R = 0.77, p < 5 E−10). This information reveals that the cortical shell plays a major role in determining the load carrying capacity of lumbar vertebrae, and that examination of cortical thickness will give an approximation of maximum vertebral stress and load.

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