Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones

Bone ◽  
2019 ◽  
Vol 120 ◽  
pp. 219-231 ◽  
Author(s):  
Yuko Katoh-Fukui ◽  
Takashi Baba ◽  
Tetsuya Sato ◽  
Hiroyuki Otake ◽  
Yuko Nagakui-Noguchi ◽  
...  
Keyword(s):  
Adipogenic Differentiation ◽  
Polycomb Group ◽  
Long Bones ◽  
Polycomb Group Gene

scholarly journals Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A

2006 ◽  
Vol 123 (4) ◽  
pp. 312-320 ◽  
Author(s):  
Mar Lorente ◽  
Claudia Pérez ◽  
Carmen Sánchez ◽  
Mary Donohoe ◽  
Yang Shi ◽  
...  
Keyword(s):  
Genetic Interaction ◽  
Axial Skeleton ◽  
Polycomb Group ◽  
Mutant Mice ◽  
Polycomb Group Gene

Participation of Polycomb group gene extra sex combs in hedgehog signaling pathway

2004 ◽  
Vol 323 (2) ◽  
pp. 523-533 ◽  
Author(s):  
Norihisa Shindo ◽  
Atsushi Sakai ◽  
Kouji Yamada ◽  
Toru Higashinakagawa
Keyword(s):  
Signaling Pathway ◽  
Hedgehog Signaling ◽  
Polycomb Group ◽  
Hedgehog Signaling Pathway ◽  
Sex Combs ◽  
Polycomb Group Gene

Chemokine-mediated thymopoiesis is regulated by a mammalian Polycomb group gene, mel-18

2002 ◽  
Vol 80 (2) ◽  
pp. 139-143 ◽  
Author(s):  
Kozue Miyazaki ◽  
Hiroko Inoue ◽  
Nobuyuki Onai ◽  
Hiroto Ishihara ◽  
Masamoto Kanno
Keyword(s):  
Polycomb Group ◽  
Polycomb Group Gene

Deletion of the polycomb-group gene EZH2 causes myeloproleferative neoplasm in mice

2013 ◽  
Vol 41 (8) ◽  
pp. S54
Author(s):  
Makiko Mochizuki-Kashio ◽  
Goro Sashida ◽  
Tomoya Muto ◽  
George Wendt ◽  
Atsushi Iwama
Keyword(s):  
Polycomb Group ◽  
Polycomb Group Gene

E(z): a polycomb group gene or a trithorax group gene?

Development ◽  
1996 ◽  
Vol 122 (7) ◽  
pp. 2189-2197 ◽  
Author(s):  
D. LaJeunesse ◽  
A. Shearn
Keyword(s):  
Polycomb Group ◽  
Bithorax Complex ◽  
Trithorax Group ◽  
Polycomb Group Genes ◽  
Enhancer Of Zeste ◽  
Selector Genes ◽  
Homeotic Selector Genes ◽  
Polycomb Group Gene ◽  
Anterior Posterior ◽  
Homeotic Selector

The products of the Polycomb group of genes are cooperatively involved in repressing expression of homeotic selector genes outside of their appropriate anterior/posterior boundaries. Loss of maternal and/or zygotic function of Polycomb group genes results in the ectopic expression of both Antennapedia Complex and Bithorax Complex genes. The products of the trithorax group of genes are cooperatively involved in maintaining active expression of homeotic selector genes within their appropriate anterior/posterior boundaries. Loss of maternal and/or zygotic function of trithorax group genes results in reduced expression of both Antennapedia Complex and Bithorax Complex genes. Although Enhancer of zeste has been classified as a member of the Polycomb group, in this paper we show that Enhancer of zeste can also be classified as a member of the trithorax group. The requirement for Enhancer of zeste activity as either a trithorax group or Polycomb group gene depends on the homeotic selector gene locus as well as on spatial and temporal cues.

scholarly journals The Maternally Expressed Polycomb Group Gene OsEMF2a Is Essential for Endosperm Cellularization and Imprinting in Rice

2020 ◽  
pp. 100092
Author(s):  
Xiaojun Cheng ◽  
Meiyao Pan ◽  
Zhiguo E ◽  
Yong Zhou ◽  
Baixiao Niu ◽  
...  
Keyword(s):  
Polycomb Group ◽  
Polycomb Group Gene

scholarly journals Polycomb Group Gene E(z) Is Required for Spermatogonial Dedifferentiation in Drosophila Adult Testis

2017 ◽  
Vol 429 (13) ◽  
pp. 2030-2041 ◽  
Author(s):  
Suk Ho Eun ◽  
Lijuan Feng ◽  
Luis Cedeno-Rosario ◽  
Qiang Gan ◽  
Gang Wei ◽  
...  
Keyword(s):  
Polycomb Group ◽  
Adult Testis ◽  
Polycomb Group Gene

scholarly journals Mesenchymal Progenitors Derived from Different Locations in Long Bones Display Diverse Characteristics

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Weiguang Lu ◽  
Bo Gao ◽  
Jing Fan ◽  
Pengzhen Cheng ◽  
Yaqian Hu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipogenic Differentiation ◽  
Osteoclast Formation ◽  
Long Bones ◽  
Differentiation Potential ◽  
Mesenchymal Progenitors ◽  
Multiple Differentiation ◽  
Osteoclastic Differentiation ◽  
Proliferation Assays

Mesenchymal progenitors within bone marrow have multiple differentiation potential and play an essential role in the maintenance of adult skeleton homeostasis. Mesenchymal progenitors located in bone regions other than the bone marrow also display bone-forming properties. However, owing to the differences in each distinct microenvironment, the mesenchymal characteristics of skeletal progenitor cells within different regions of long bones may show some differences. In order to clearly elucidate these differences, we performed a comparative study on mesenchymal progenitors from different regions of long bones. Here, we isolated mesenchymal progenitors from the periosteum, endosteum, and bone marrow of rat long bones. The three groups exhibited similar cellular morphologies and expressed the typical surface markers associated with mesenchymal stem cells. Interestingly, after cell proliferation assays and bidirectional differentiation analysis, periosteal mesenchymal progenitors showed a higher proliferative ability and adipogenic differentiation potential. In contrast, endosteal mesenchymal progenitors were more prone to osteogenic differentiation. Using in vitro osteoclast culture systems, conditioned media from different mesenchymal progenitor cultures were used to induce osteoclastic differentiation. Osteoclast formation was found to be significantly promoted by the secretion of RANKL and IL-6 by endosteal progenitors. Overall, our results provide strong evidence for the importance of selecting the appropriate source of skeletal progenitors for applications in future skeleton regeneration therapies.

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