Bone matrix hypermineralization associated with low bone turnover in a case of Nasu-Hakola disease

Bone ◽  
2019 ◽  
Vol 123 ◽  
pp. 48-55 ◽  
Author(s):  
Mohammad Shboul ◽  
Paul Roschger ◽  
Rudolf Ganger ◽  
Lefteris Paschalis ◽  
Stamatia Rokidi ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Matrix ◽  
Low Bone Turnover

Effect of pancreas transplantation on decreased levels of circulating bone γ-carboxyglutamic acid-containing protein and osteopenia in rats with streptozotocin-induced diabetes

1992 ◽  
Vol 127 (1) ◽  
pp. 81-85 ◽  
Author(s):  
Hitoshi Ishida ◽  
Yutaka Seino ◽  
Noritaka Takeshita ◽  
Takeshi Kurose ◽  
Kazuo Tsuji ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Turnover ◽  
Pancreas Transplantation ◽  
Diabetic Rats ◽  
Chronic Complications ◽  
Carboxyglutamic Acid ◽  
Low Bone Turnover ◽  
Streptozotocin Induced Diabetes ◽  
Diabetic Osteopenia

Diabetic osteopenia has been known as one of the chronic complications of diabetes mellitus, and a decrease in bone turnover has been thought to be one of the pathophysiological characteristics of this complication. In order to investigate the effect of long-term insulin therapy on low bone turnover in diabetes, pancreas transplantation was performed on streptozotocin-induced diabetic rats. Plasma levels of bone γ-carboxyglutamic acid-containing protein(osteocalcin) in untreated diabetic rats were 0.9±0.1 (mean±sem) nmol/l, significantly lower than the value of 4.2±0.6 nmol/l in control rats (p<0.01). Pancreas transplantation reversed this decrease to 6.3±1.1 nmol/l, which was not significantly different from the value in control rats. The circulating levels of calcitriol were significantly decreased in the untreated diabetic group (p<0.01), and the decrease was fully reversed by pancreas transplantation. In addition, the decreases in bone length, strength and weight were also improved by the transplantation. This evidence clearly shows that the improvement of metabolic derangements in diabetes by insulin is essential for the prevention of deterioration in diabetic osteopenia. It is possible, therefore, that insulin exerts an indirect beneficial influence through the metabolic amelioration on the decreases in bone turnover and circulating osteocalcin in diabetes mellitus, or has a direct stimulatory effect on the osteoblasts via the insulin receptor since its presence has been shown recently in osteoblastic cells.

Fragility Fractures in Men with Idiopathic Osteoporosis Are Associated with Undermineralization of the Bone Matrix without Evidence of Increased Bone Turnover

2011 ◽  
Vol 88 (5) ◽  
pp. 378-387 ◽  
Author(s):  
Nadja Fratzl-Zelman ◽  
Paul Roschger ◽  
Barbara M. Misof ◽  
Kamilla Nawrot-Wawrzyniak ◽  
Sarah Pötter-Lang ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Matrix ◽  
Fragility Fractures ◽  
Idiopathic Osteoporosis

scholarly journals SP360DIRECT RENIN INHIBITOR ALISKIREN AMELIORATES LOW BONE TURNOVER IN DIABETIC RAT

2017 ◽  
Vol 32 (suppl_3) ◽  
pp. iii232-iii233 ◽  
Author(s):  
Shunsuke Goto ◽  
Hideki Fujii ◽  
Rie Awata ◽  
Keiji Kono ◽  
Kentaro Nakai ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Renin Inhibitor ◽  
Diabetic Rat ◽  
Low Bone Turnover

Three years of treatment with once-yearly zoledronic acid influences the kinetics of bone matrix maturation in osteoporotic patients independent of bone turnover

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S78-S79
Author(s):  
S. Gamsjaeger ◽  
B. Buchinger ◽  
J. Gasser ◽  
E.F. Eriksen ◽  
K. Klaushofer ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Bone Turnover ◽  
Bone Matrix ◽  
Matrix Maturation ◽  
Kinetics Of
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