Cortical bone loss due to skeletal unloading in aldehyde dehydrogenase 2 gene knockout mice is associated with decreased PTH receptor expression in osteocytes

Bone ◽  
2018 ◽  
Vol 110 ◽  
pp. 254-266 ◽  
Author(s):  
Takafumi Tajima ◽  
Kunitaka Menuki ◽  
Kayoko Furukawa Okuma ◽  
Manabu Tsukamoto ◽  
Hokuto Fukuda ◽  
...  
Keyword(s):  
Bone Loss ◽  
Aldehyde Dehydrogenase ◽  
Knockout Mice ◽  
Gene Knockout ◽  
Receptor Expression ◽  
Aldehyde Dehydrogenase 2 ◽  
Skeletal Unloading ◽  
Cortical Bone Loss ◽  
Gene Knockout Mice ◽  
Aldehyde Dehydrogenase 2 Gene

scholarly journals Inhibition of Oxytocin Receptor and Estrogen Receptor-α Expression, But Not Relaxin Receptors (LGR7), in the Myometrium of Late Pregnant Relaxin Gene Knockout Mice

Endocrinology ◽  
2003 ◽  
Vol 144 (10) ◽  
pp. 4272-4275 ◽  
Author(s):  
Andrew L. Siebel ◽  
Helen M. Gehring ◽  
Irna Grace T. Reytomas ◽  
Laura J. Parry
Keyword(s):  
Gene Expression ◽  
Estrogen Receptor ◽  
Knockout Mice ◽  
Gene Knockout ◽  
Estrogen Receptor Α ◽  
Oxytocin Receptor ◽  
Receptor Expression ◽  
Late Gestation ◽  
Mrna Levels ◽  
Gene Knockout Mice

This study used relaxin (RLX) gene knockout mice (Rlx−/−) to investigate the effects of RLX on myometrial oxytocin receptor (OTR) and estrogen receptor (ER)-α gene expression in late gestation. We also characterized the temporal expression of the RLX receptor (LGR7) and demonstrated gene transcripts in the myometrium of Rlx+/+ and Rlx−/− mice. There was a significant (P < 0.05) decrease in myometrial LGR7 gene expression on d 17.5 and 18.5 post coitum (pc) compared with earlier stages of gestation, but no differences between Rlx+/+ and Rlx−/− mice. Myometrial OTR mRNA levels increased at the end of gestation in Rlx+/+ but not Rlx−/− mice. ERα gene expression was up-regulated on d 14.5 pc in Rlx+/+ mice, with mRNA levels remaining high throughout late gestation. In contrast, ERα mRNA levels were significantly lower in Rlx−/− mice on d 14.5 and 18.5 pc. These data show that the increases in myometrial OTR and ERα expression in late pregnant Rlx+/+ mice were attenuated in Rlx−/− mice. The effects of RLX on OTRs are probably mediated via activation of ERα. Finally, RLX receptor expression in the myometrium of Rlx−/− mice did not differ from wild-type mice, implying that RLX does not influence expression of its receptor.

Detrimental implication of B1 receptors in myocardial ischemia: evidence from pharmacological blockade and gene knockout mice

2002 ◽  
Vol 2 (6) ◽  
pp. 815-822 ◽  
Author(s):  
Caroline Lagneux ◽  
Michael Bader ◽  
João B. Pesquero ◽  
Pierre Demenge ◽  
Christophe Ribuot
Keyword(s):  
Myocardial Ischemia ◽  
Knockout Mice ◽  
Gene Knockout ◽  
B1 Receptors ◽  
Gene Knockout Mice ◽  
Pharmacological Blockade

Enhanced antinociceptive effects of morphine in histamine H2 receptor gene knockout mice

2006 ◽  
Vol 51 (3) ◽  
pp. 612-622 ◽  
Author(s):  
Jalal Izadi Mobarakeh ◽  
Kazuhiro Takahashi ◽  
Shinobu Sakurada ◽  
Atsuo Kuramasu ◽  
Kazuhiko Yanai
Keyword(s):  
Knockout Mice ◽  
Gene Knockout ◽  
Receptor Gene ◽  
Histamine H2 Receptor ◽  
H2 Receptor ◽  
Antinociceptive Effects ◽  
Gene Knockout Mice

scholarly journals Increased glycosphingolipid levels in serum and aortae of apolipoprotein E gene knockout mice

2002 ◽  
Vol 43 (2) ◽  
pp. 205-214 ◽  
Author(s):  
Brett Garner ◽  
David A. Priestman ◽  
Roland Stocker ◽  
David J. Harvey ◽  
Terry D. Butters ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Knockout Mice ◽  
Gene Knockout ◽  
E Gene ◽  
Apolipoprotein E Gene ◽  
Gene Knockout Mice

Serotonin2A/C receptors mediate the aggressive phenotype of TLX gene knockout mice

2013 ◽  
Vol 256 ◽  
pp. 354-361 ◽  
Author(s):  
Pablo Juárez ◽  
Maria G. Valdovinos ◽  
Michael E. May ◽  
Blair P. Lloyd ◽  
Maria H. Couppis ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Gene Knockout ◽  
Aggressive Phenotype ◽  
Gene Knockout Mice

scholarly journals Age-Dependent Defects of Regulatory B Cells in Wiskott-Aldrich Syndrome Gene Knockout Mice

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0139729 ◽  
Author(s):  
Tadafumi Yokoyama ◽  
Ayumi Yoshizaki ◽  
Karen L. Simon ◽  
Martha R. Kirby ◽  
Stacie M. Anderson ◽  
...  
Keyword(s):  
B Cells ◽  
Knockout Mice ◽  
Gene Knockout ◽  
Regulatory B Cells ◽  
Wiskott Aldrich Syndrome ◽  
Age Dependent ◽  
Gene Knockout Mice

The application of transgenic and gene knockout mice in the study of gastric precancerous lesions

2018 ◽  
Vol 214 (12) ◽  
pp. 1929-1939 ◽  
Author(s):  
Wei Liu ◽  
Hua-feng Pan ◽  
Qi Wang ◽  
Zi-ming Zhao
Keyword(s):  
Knockout Mice ◽  
Gene Knockout ◽  
Precancerous Lesions ◽  
Gene Knockout Mice
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