A case report of mesenteric heterotopic ossification: Histopathologic and genetic findings

Bone ◽  
2018 ◽  
Vol 109 ◽  
pp. 56-60 ◽  
Author(s):  
Matthew Amalfitano ◽  
Billie Fyfe ◽  
Sumi V. Thomas ◽  
Kevin P. Egan ◽  
Meiqi Xu ◽  
...  
Keyword(s):  
Case Report ◽  
Heterotopic Ossification

scholarly journals Heterotopic ossification in lymph node metastasis after rectal cancer resection: a case report and literature review

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hideki Nagano ◽  
Tamotsu Togawa ◽  
Takeshi Watanabe ◽  
Kenji Ohnishi ◽  
Toshihisa Kimura ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Case Report ◽  
Lymph Node ◽  
Heterotopic Ossification ◽  
Tumor Cells ◽  
Digestive Tract ◽  
Histological Examination ◽  
Metastatic Lesion ◽  
Axillary Lymph ◽  
The Brain

Abstract Background Heterotopic ossification (HO) is the formation of osseous tissue outside the skeleton. HO in malignant tumors of the digestive tract is extremely rare, as is ossification in metastatic lesions from HO-negative digestive tract tumors. Regarding the pathogenesis of HO, two theories have been proposed. The first is that the osteoblastic metaplasia of tumor cells (driven by the epithelial-mesenchymal transition, EMT) results in HO, and the second is that factors secreted by cancer cells lead to the metaplasia of stromal pluripotent cells into osteoblasts. However, the osteogenic mechanisms remain unclear. Case presentation An 83-year-old Japanese woman underwent low anterior rectal resection for rectal cancer before presentation at our institution, in June 2018. The final diagnosis was stage IIB rectal adenocarcinoma (T4aN0M0). Histological examination did not reveal HO in the primary tumor. Thirteen months after the operation, a solitary metastatic lesion in the brain 20 mm in size and a solitary metastatic lesion in a right axillary lymph node 20 mm in size were diagnosed. The patient was treated with gamma-knife therapy for the brain metastasis. One month later, she was referred to our institution. She underwent lymph node resection. Histological examination revealed that most portions of the affected lymph node were occupied by metastatic tumor cells and that central necrosis and four small ossified lesions without an osteoblast-like cell rim were present in the peripheral region. Immunohistochemical analysis showed tumor cells positive for BMP-2, osteonectin, osteocalcin, AE1/AE3, TGF-β1, Gli2, Smad2/3, and CDX2 and negative for nestin, CD56, and CK7. Conclusion This is the first English case report of HO in a metachronous metastatic lymph node after the curative resection of HO-negative rectal cancer. Unlike HO lesions in past reports, the HO lesion did not show peripheral osteoblast-like cells, and the immunohistochemical findings indicated that the present case resulted from the EMT.

scholarly journals Heterotopic Ossification of the Peroneus Longus Tendon in the Retromalleolar Portion with the Peroneus Quartus Muscle: A Case Report

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Song Ho Chang ◽  
Takumi Matsumoto ◽  
Koichi Okajima ◽  
Masashi Naito ◽  
Jun Hirose ◽  
...  
Keyword(s):  
Case Report ◽  
Heterotopic Ossification ◽  
Soft Tissues ◽  
Calcific Tendinitis ◽  
Lamellar Bone ◽  
Peroneus Longus Tendon ◽  
Histological Features ◽  
Longus Tendon ◽  
Peroneus Longus ◽  
Cuboid Bone

Heterotopic ossification (HO) is an ectopic formation of the lamellar bone in the soft tissues. Some authors have previously reported HO or calcific tendinitis of the peroneus longus tendon at the level of the cuboid bone, while the HO of the peroneus longus tendon in the retromalleolar portion has not been reported. The purpose of this report is to describe clinical, radiological, and histological features of this rare ossification and its treatment. To the best of our knowledge, this is the first report presenting a case of HO of the peroneus longus tendon, which developed in the retromalleolar portion.

scholarly journals Plantar Keratosis Induced by Heterotopic Ossification under the Medial Sesamoid Bone: A Case Report

2020 ◽  
Vol 24 (3) ◽  
pp. 120-123
Author(s):  
Seung Joo Kim ◽  
Jin Soo Suh ◽  
Ji Ye Kim ◽  
Jun Young Choi
Keyword(s):  
Case Report ◽  
Heterotopic Ossification ◽  
Sesamoid Bone

Traumatic Heterotopic Ossification of the Elbow in Children — a Case Report

2010 ◽  
Vol 110 (2) ◽  
pp. 246-249 ◽  
Author(s):  
T. Šušnjar ◽  
M. Biočić ◽  
Z. Pogorelić
Keyword(s):  
Case Report ◽  
Heterotopic Ossification
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