Comparison of calcimimetic R568 and calcitriol in mineral homeostasis in the Hyp mouse, a murine homolog of X-linked hypophosphatemia

Bone ◽  
2017 ◽  
Vol 103 ◽  
pp. 224-232 ◽  
Author(s):  
Maren Leifheit-Nestler ◽  
Julia Kucka ◽  
Emi Yoshizawa ◽  
Geert Behets ◽  
Patrick D'Haese ◽  
...  
Keyword(s):  
Mineral Homeostasis ◽  
Murine Homolog

Mineral homeostasis and bone mass in children treated for acute lymphoblastic leukemia

1989 ◽  
Vol 114 (5) ◽  
pp. 793-800 ◽  
Author(s):  
Stephanie A. Atkinson ◽  
Lawrence Fraher ◽  
Caren M. Gundberg ◽  
Maureen Andrew ◽  
Mohan Pai ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Bone Mass ◽  
Lymphoblastic Leukemia ◽  
Mineral Homeostasis

scholarly journals Transcriptional responses in jejunum of two layer chicken strains following variations in dietary calcium and phosphorus levels

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Henry Reyer ◽  
Michael Oster ◽  
Siriluck Ponsuksili ◽  
Nares Trakooljul ◽  
Adewunmi O. Omotoso ◽  
...  
Keyword(s):  
Vitamin D ◽  
High Performance ◽  
Absorption Capacity ◽  
Egg Laying ◽  
Endocrine Regulation ◽  
Transcriptional Responses ◽  
Endogenous Factors ◽  
Mineral Homeostasis ◽  
Laying Performance ◽  
Vitamin D Levels

Abstract Background Calcium (Ca) and phosphorus (P) are essential nutrients that are linked to a large array of biological processes. Disturbances in Ca and P homeostasis in chickens are associated with a decline in growth and egg laying performance and environmental burden due to excessive P excretion rates. Improved utilization of minerals in particular of P sources contributes to healthy growth while preserving the finite resource of mineral P and mitigating environmental pollution. In the current study, high performance Lohmann Selected Leghorn (LSL) and Lohmann Brown (LB) hens at peak laying performance were examined to approximate the consequences of variable dietary Ca and P supply. The experimental design comprised four dietary groups with standard or reduced levels of either Ca or P or both (n = 10 birds per treatment group and strain) in order to stimulate intrinsic mechanisms to maintain homeostasis. Jejunal transcriptome profiles and the systemic endocrine regulation of mineral homeostasis were assessed (n = 80). Results Endogenous mechanisms to maintain mineral homeostasis in response to variations in the supply of Ca and P were effective in both laying hen strains. However, the LSL and LB appeared to adopt different molecular pathways, as shown by circulating vitamin D levels and strain-specific transcriptome patterns. Responses in LSL indicated altered proliferation rates of intestinal cells as well as adaptive responses at the level of paracellular transport and immunocompetence. Endogenous mechanisms in LB appeared to involve a restructuring of the epithelium, which may allow adaptation of absorption capacity via improved micro-anatomical characteristics. Conclusions The results suggest that LSL and LB hens may exhibit different Ca, P, and vitamin D requirements, which have so far been neglected in the supply recommendations. There is a demand for trial data showing the mechanisms of endogenous factors of Ca and P homeostasis, such as vitamin D, at local and systemic levels in laying hens.

Overexpression of the forebrain-specific homeobox gene six3 induces rostral forebrain enlargement in zebrafish

Development ◽  
1998 ◽  
Vol 125 (15) ◽  
pp. 2973-2982 ◽  
Author(s):  
M. Kobayashi ◽  
R. Toyama ◽  
H. Takeda ◽  
I.B. Dawid ◽  
K. Kawakami
Keyword(s):  
Homeobox Gene ◽  
Cloning And Expression ◽  
Optic Stalk ◽  
Sine Oculis ◽  
Murine Homolog ◽  
Enhanced Expression ◽  
Rostral Region ◽  
The Brain ◽  
Early Gastrula ◽  
Anterior Neural Plate

The Drosophila homeobox gene sine oculis is expressed in the rostral region of the embryo in early development and is essential for eye and brain formation. Its murine homolog, Six3, is expressed in the anterior neural plate and eye anlage, and may have crucial functions in eye and brain development. In this study, we describe the cloning and expression of zebrafish six3, the apparent ortholog of the mouse Six3 gene. Zebrafish six3 transcripts are first seen in hypoblast cells in early gastrula embryos and are found in the anterior axial mesendoderm through gastrulation. six3 expression in the head ectoderm begins at late gastrula. Throughout the segmentation period, six3 is expressed in the rostral region of the prospective forebrain. Overexpression of six3 in zebrafish embryos induced enlargement of the rostral forebrain, enhanced expression of pax2 in the optic stalk and led to a general disorganization of the brain. Disruption of either the Six domain or the homeodomain abolish these effects, implying that these domains are essential for six3 gene function. Our results suggest that the vertebrate Six3 genes are involved in the formation of the rostral forebrain.

scholarly journals Interaction ofBTG1and p53-regulatedBTG2Gene Products with mCaf1, the Murine Homolog of a Component of the Yeast CCR4 Transcriptional Regulatory Complex

1998 ◽  
Vol 273 (35) ◽  
pp. 22563-22569 ◽  
Author(s):  
Jean-Pierre Rouault ◽  
Déborah Prévôt ◽  
Cyril Berthet ◽  
Anne-Marie Birot ◽  
Marc Billaud ◽  
...  
Keyword(s):  
Transcriptional Regulatory ◽  
Murine Homolog ◽  
Regulatory Complex

scholarly journals The Murine Neuronal Receptor NgR1 Is Dispensable for Reovirus Pathogenesis

2021 ◽  
Author(s):  
Pavithra Aravamudhan ◽  
Camila Guzman-Cardozo ◽  
Kelly Urbanek ◽  
Olivia Welsh ◽  
Jennifer Konopka-Anstadt ◽  
...  
Keyword(s):  
Expression Patterns ◽  
Target Cells ◽  
Viral Attachment ◽  
Genetic Ablation ◽  
Murine Homolog ◽  
Intramuscular Inoculation ◽  
Neural Tissues ◽  
Mammalian Orthoreovirus ◽  
The Brain

Engagement of host receptors is essential for viruses to enter target cells and initiate infection. Expression patterns of receptors in turn dictate host and tissue tropism and disease pathogenesis during infection. Mammalian orthoreovirus (reovirus) displays serotype-dependent patterns of tropism in the murine central nervous system (CNS) that are dictated by viral attachment protein σ1. However, the receptor that mediates reovirus CNS tropism is unknown. Two proteinaceous receptors have been identified for reovirus, junctional adhesion molecule-A (JAM-A) and Nogo 66 receptor 1 (NgR1). Engagement of JAM-A is required for reovirus hematogenous dissemination but is dispensable for neural spread. To determine whether NgR1 functions in reovirus neuropathogenesis, we compared virus replication and disease following inoculation of wild-type (WT) and NgR1-/- mice. Genetic ablation of NgR1 did not alter replication of neurotropic reovirus strain T3SA- in the intestine and transmission to the brain following peroral inoculation. Viral titers in neural tissues following intramuscular inoculation, which provides access to neural dissemination routes, also were comparable in WT and NgR1-/- mice, suggesting that NgR1 is dispensable for reovirus neural spread to the CNS. The absence of both NgR1 and JAM-A also did not alter replication, neural tropism, and virulence of T3SA- following direct intracranial inoculation. In agreement with these findings, we found that the human but not the murine homolog of NgR1 functions as a receptor and confers efficient reovirus binding and infection of nonsusceptible cells in vitro. These results eliminate functions for JAM-A and NgR1 in shaping CNS tropism in mice and suggest that other receptors, yet to be identified, support this function.

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