scholarly journals Acute lung injury complicating acute kidney injury: A model of endogenous αKlotho deficiency and distant organ dysfunction

Bone ◽  
2017 ◽  
Vol 100 ◽  
pp. 100-109 ◽  
Author(s):  
Connie C.W. Hsia ◽  
Priya Ravikumar ◽  
Jianfeng Ye
Keyword(s):  
Acute Kidney Injury ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Organ Dysfunction ◽  
Kidney Injury ◽  
Distant Organ

scholarly journals Acute kidney injury in patients with acute lung injury: Impact of fluid accumulation on classification of acute kidney injury and associated outcomes*

2011 ◽  
Vol 39 (12) ◽  
pp. 2665-2671 ◽  
Author(s):  
Kathleen D. Liu ◽  
B. Taylor Thompson ◽  
Marek Ancukiewicz ◽  
Jay S. Steingrub ◽  
Ivor S. Douglas ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Kidney Injury ◽  
Fluid Accumulation

scholarly journals Indoxyl Sulfate as a Mediator Involved in Dysregulation of Pulmonary Aquaporin-5 in Acute Lung Injury Caused by Acute Kidney Injury

2016 ◽  
Vol 18 (1) ◽  
pp. 11 ◽  
Author(s):  
Nozomi Yabuuchi ◽  
Masataka Sagata ◽  
Chika Saigo ◽  
Go Yoneda ◽  
Yuko Yamamoto ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Kidney Injury ◽  
Indoxyl Sulfate ◽  
Aquaporin 5

scholarly journals αKlotho deficiency in acute kidney injury contributes to lung damage

2016 ◽  
Vol 120 (7) ◽  
pp. 723-732 ◽  
Author(s):  
Priya Ravikumar ◽  
Liping Li ◽  
Jianfeng Ye ◽  
Mingjun Shi ◽  
Masatomo Taniguchi ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Oxidative Damage ◽  
Ischemia Reperfusion ◽  
Kidney Injury ◽  
Lung Epithelial Cells ◽  
Lung Edema ◽  
Related Factor ◽  
Antioxidative Capacity

αKlotho is a circulating protein that originates predominantly from the kidney and exerts cytoprotective effects in distant sites. We previously showed in rodents that the lung is particularly vulnerable to αKlotho deficiency. Because acute lung injury is a common and serious complication of acute kidney injury (AKI), we hypothesized that αKlotho deficiency in AKI contributes to lung injury. To test the hypothesis, we created AKI by renal artery ischemia-reperfusion in rats and observed the development of alveolar interstitial edema and increased pulmonary oxidative damage to DNA, protein, and lipids. Administration of αKlotho-containing conditioned media 6 h post-AKI did not alter plasma creatinine but improved recovery of endogenous αKlotho production 3 days post-AKI, reduced lung edema and oxidative damage, and increased endogenous antioxidative capacity in the lung. Intravenously injected αKlotho rapidly exits alveolar capillaries as a macromolecule, suggesting transcytosis and direct access to the epithelium. To explore the epithelial action of αKlotho, we simulated oxidative stress in vitro by adding hydrogen peroxide to cultured A549 lung epithelial cells. Purified recombinant αKlotho directly protected cells at 20 pM with half-maximal effects at 40-50 pM, which is compatible with circulating αKlotho levels. Addition of recombinant αKlotho activated an antioxidant response element reporter and increased the levels of target proteins of the nuclear factor erythroid-derived 2 related factor system. In summary, αKlotho deficiency in AKI contributes to acute lung injury by reducing endogenous antioxidative capacity and increasing oxidative damage in the lung. αKlotho replacement partially reversed these abnormalities and mitigated pulmonary complications in AKI.

Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury *

2007 ◽  
Vol 35 (12) ◽  
pp. 2755-2761 ◽  
Author(s):  
Kathleen D. Liu ◽  
David V. Glidden ◽  
Mark D. Eisner ◽  
Polly E. Parsons ◽  
Lorraine B. Ware ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Kidney Injury ◽  
Plasma Biomarkers
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