scholarly journals Serum 25-hydroxyvitamin D level and incident type 2 diabetes in older men, the Osteoporotic Fractures in Men (MrOS) study

Bone ◽  
2016 ◽  
Vol 90 ◽  
pp. 181-184 ◽  
Author(s):  
Nicola Napoli ◽  
Anne L. Schafer ◽  
Li-Yung Lui ◽  
Jane A. Cauley ◽  
Elsa S. Strotmeyer ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Osteoporotic Fractures ◽  
Older Men ◽  
Incident Type ◽  
Hydroxyvitamin D ◽  
Incident Type 2 Diabetes ◽  
25 Hydroxyvitamin D

scholarly journals Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study

2010 ◽  
Vol 91 (6) ◽  
pp. 1627-1633 ◽  
Author(s):  
Enju Liu ◽  
James B Meigs ◽  
Anastassios G Pittas ◽  
Christina D Economos ◽  
Nicola M McKeown ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Incident Type ◽  
Hydroxyvitamin D ◽  
Incident Type 2 Diabetes ◽  
25 Hydroxyvitamin D

scholarly journals Plasma 25-Hydroxyvitamin D Concentration and Risk of Incident Type 2 Diabetes in Women

Diabetes Care ◽  
2010 ◽  
Vol 33 (9) ◽  
pp. 2021-2023 ◽  
Author(s):  
A. G. Pittas ◽  
Q. Sun ◽  
J. E. Manson ◽  
B. Dawson-Hughes ◽  
F. B. Hu
Keyword(s):  
Type 2 Diabetes ◽  
Incident Type ◽  
Hydroxyvitamin D ◽  
Incident Type 2 Diabetes ◽  
25 Hydroxyvitamin D

Plasma 25-hydroxyvitamin D and its genetic determinants in relation to incident type 2 diabetes: a prospective case-cohort study

2013 ◽  
Vol 28 (9) ◽  
pp. 743-752 ◽  
Author(s):  
Brian Buijsse ◽  
Heiner Boeing ◽  
Frank Hirche ◽  
Cornelia Weikert ◽  
Matthias B. Schulze ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Genetic Determinants ◽  
Incident Type ◽  
Hydroxyvitamin D ◽  
Incident Type 2 Diabetes ◽  
25 Hydroxyvitamin D

scholarly journals Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study

2015 ◽  
Vol 3 (1) ◽  
pp. 35-42 ◽  
Author(s):  
Zheng Ye ◽  
Stephen J Sharp ◽  
Stephen Burgess ◽  
Robert A Scott ◽  
Fumiaki Imamura ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mendelian Randomisation ◽  
Incident Type ◽  
Hydroxyvitamin D ◽  
Incident Type 2 Diabetes ◽  
25 Hydroxyvitamin D

[beta]eta-hydroxybutyrate and risk for incident type 2 diabetes: results from the prevend prospective cohort study

2019 ◽  
Author(s):  
Jose L Flores-Guerrero ◽  
Margery A Connelly ◽  
Dion Groothof ◽  
Eke G Gruppen ◽  
Stephan JL Bakker ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Association of serum 25-hydroxyvitamin D with metabolic syndrome and type 2 diabetes: a one sample Mendelian randomization study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jing Xiao ◽  
Jingyi Lv ◽  
Shiyu Wang ◽  
Yang Zhou ◽  
Lunwen Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Metabolic Syndrome ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Mendelian Randomization ◽  
Middle Aged ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
Randomization Analysis

Abstract Background Vitamin D deficiency has been associated with type 2 diabetes (T2D) and metabolic syndrome (MS) and its components. However, it is unclear whether a low concentration of vitamin D is the cause or consequence of these health conditions. Thus, this study aimed to evaluate the association of vitamin D concentrations and its genetic risk scores (GRSs) with MS and its component diseases, such as T2D, in middle-aged and elderly participants from rural eastern China. Methods A subset of 2393 middle-aged and elderly individuals were selected from 70,458 participants of the Nantong Chronic Diseases Study of 2017–2018 in China. We used two 25-hydroxyvitamin D (25[OH]D) synthesis single-nucleotide polymorphisms (SNPs) (DHCR7-rs12785878 and CYP2R1-rs10741657) and two 25(OH) D metabolism SNPs (GC-rs2282679 and CYP24A1-rs6013897) for creating GRSs, which were used as instrumental variables to assess the effect of genetically lowered 25(OH) D concentrations on MS and T2D based on the Wald ratio. F statistics were used to validate that the four SNPs genetically determined 25(OH) D concentrations. Results Compared to vitamin D sufficient individuals, individuals with vitamin D insufficiency had an odds ratio (OR [95% confidence interval {CI}]) of MS of 1.30 (1.06–1.61) and of T2D of 1.32 (1.08–1.64), individuals with vitamin D deficiency had an ORs (95% CI) of MS of 1.50 (1.24–1.79) and of T2D of 1.47 (1.12–1.80), and those with vitamin D severe deficiency had an ORs (95% CI) of MS of 1.52 (1.29–1.85) and of T2D of 1.54 (1.27–1.85). Mendelian randomization analysis showed a 25-nmol/L decrease in genetically instrumented serum 25(OH) D concentrations using the two synthesis SNPs (DHCR7 and CYP2R1 genes) associated with the risk of T2D and abnormal diastolic blood pressure (DBP) with ORs of 1.10 (95%CI: 1.02–1.45) for T2D and 1.14 (95%CI: 1.03–1.43) for DBP. Conclusions This one sample Mendelian randomization analysis shows genetic evidence for a causal role of lower 25(OH) D concentrations in promoting of T2D and abnormal DBP in middle-aged and elderly participants from rural China.

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