scholarly journals Cluster analysis of bone microarchitecture from high resolution peripheral quantitative computed tomography demonstrates two separate phenotypes associated with high fracture risk in men and women

Bone ◽  
2016 ◽  
Vol 88 ◽  
pp. 131-137 ◽  
Author(s):  
M.H. Edwards ◽  
D.E. Robinson ◽  
K.A. Ward ◽  
M.K. Javaid ◽  
K. Walker-Bone ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Cluster Analysis ◽  
High Resolution ◽  
Fracture Risk ◽  
Bone Microarchitecture ◽  
Quantitative Computed Tomography ◽  
Peripheral Quantitative Computed Tomography ◽  
High Fracture ◽  
Men And Women

scholarly journals Sex- and Age-Related Differences in Bone Microarchitecture in Men Relative to Women Assessed by High-Resolution Peripheral Quantitative Computed Tomography

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Shreyasee Amin ◽  
Sundeep Khosla
Keyword(s):  
Computed Tomography ◽  
High Resolution ◽  
Bone Strength ◽  
Bone Biopsy ◽  
Bone Microarchitecture ◽  
Quantitative Computed Tomography ◽  
Older Men ◽  
Peripheral Quantitative Computed Tomography ◽  
Men And Women ◽  
Age Related

The trabecular and cortical compartments of bone each contributes to bone strength. Until recently, assessment of trabecular and cortical microstructure has required a bone biopsy. Now, trabecular and cortical microstructure of peripheral bone sites can be determined noninvasively using high-resolution peripheral quantitative computed tomography (HR-pQCT). Studies that have used HR-pQCT to evaluate cohorts of both men and women have provided novel insights into the changes in bone microarchitecture that occur with age between the sexes, which may help to explain the lower fracture incidence in older men relative to women. This review will highlight observations from these studies on both the sex- and age-related differences in trabecular and cortical microstructure that may underlie the differences in bone strength, and thereby fracture risk, between men and women.

scholarly journals Ethnic Differences in Bone Microarchitecture

2020 ◽  
Vol 18 (6) ◽  
pp. 803-810
Author(s):  
Ruth Durdin ◽  
Camille M Parsons ◽  
Elaine Dennison ◽  
Nicholas C Harvey ◽  
Cyrus Cooper ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Bone Density ◽  
Fracture Risk ◽  
Ethnic Differences ◽  
Bone Microarchitecture ◽  
Imaging Techniques ◽  
Quantitative Computed Tomography ◽  
Peripheral Quantitative Computed Tomography ◽  
Fracture Incidence ◽  
Advanced Imaging

Abstract Purpose of the Review The aim of this review is to briefly introduce updates in global fracture epidemiology and then to highlight recent contributions to understanding ethnic differences in bone density, geometry and microarchitecture and consider how these might contribute to differences in fracture risk. The review focuses on studies using peripheral quantitative computed tomography techniques. Recent Findings Recent studies have contributed to our understanding of the differences in fracture incidence both between countries, as well as between ethnic groups living within the same country. In terms of understanding the reasons for ethnic differences in fracture incidence, advanced imaging techniques continue to increase our understanding, though there remain relatively few studies. Summary It is a priority to continue to understand the epidemiology, and changes in the patterns of, fracture, as well as the underlying phenotypic and biological reasons for the ethnic differences which are observed.

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