The skeletal muscle cross sectional area in long-term bisphosphonate users is smaller than that of bone mineral density-matched controls with increased serum pentosidine concentrations

Bone ◽  
2015 ◽  
Vol 75 ◽  
pp. 84-87 ◽  
Author(s):  
Shigeharu Uchiyama ◽  
Shota Ikegami ◽  
Mikio Kamimura ◽  
Keijiro Mukaiyama ◽  
Yukio Nakamura ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Skeletal Muscle ◽  
Bone Mineral ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Mineral Density ◽  
Cross Sectional ◽  
Muscle Cross Sectional Area

scholarly journals The Association Between Hip Muscle Cross-Sectional Area, Muscle Strength, and Bone Mineral Density

2014 ◽  
Vol 95 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Harbeer Ahedi ◽  
Dawn Aitken ◽  
David Scott ◽  
Leigh Blizzard ◽  
Flavia Cicuttini ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Muscle Strength ◽  
Bone Mineral ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Mineral Density ◽  
Cross Sectional ◽  
Hip Muscle ◽  
Muscle Cross Sectional Area

scholarly journals Effect of Tissue-Selective Estrogen Complex on Hip Structural Geometry in Postmenopausal Women: A 12-Month Study

2021 ◽  
Vol 12 ◽  
Author(s):  
Bo Mi Kim ◽  
Sung Eun Kim ◽  
Dong-Yun Lee ◽  
DooSeok Choi
Keyword(s):  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Cortical Thickness ◽  
Bone Geometry ◽  
Cross Sectional Area ◽  
Sectional Area ◽  
Mineral Density ◽  
Hip Geometry ◽  
Cross Sectional

BackgroundHip structural analysis (HSA) is a method for evaluating bone geometry reflecting bone structural and biomechanical properties. However, tissue-selective estrogen complex (TSEC) treatment effects on HSA have not been investigated.ObjectiveThis study was performed to evaluate the effect of TSEC treatment on hip geometry in postmenopausal Korean women. The treatment was given for 12 months, and hip geometry was measured by HSA.Materials and MethodsA total of 40 postmenopausal women who received TSEC containing conjugated estrogen 0.45 mg and bazedoxifene 20 mg for treating vasomotor symptoms were included in this retrospective cohort study. The changes in bone mineral density and parameters of HSA including the outer diameter, cross-sectional area, cross-sectional moment of inertia, cortical thickness, section modulus, and buckling ratio as determined by dual-energy X-ray absorptiometry were compared before and after 12 months of TSEC treatment.ResultsMean age and years since menopause were 55.1 and 4.5 years, respectively. Total hip bone mineral density significantly increased by 0.74% after treatment (P=0.011). The changes in HSA were mainly demonstrated in the narrow femoral neck: cross-sectional area (P=0.003) and cortical thickness (P<0.001) increased significantly. For the shaft region, only SM decreased significantly after treatment (P=0.009). However, most parameters did not change significantly with TSEC treatment in the intertrochanteric and shaft regions.ConclusionsOur findings demonstrate that 12 months of TSEC treatment could improve bone geometry as measured by HSA. The findings suggest that TSEC might be an interesting option for the prevention of fracture as well as osteoporosis in postmenopausal women.

Relationship among running mileage, bone density, and serum testosterone in male runners

1992 ◽  
Vol 73 (3) ◽  
pp. 1165-1170 ◽  
Author(s):  
J. D. MacDougall ◽  
C. E. Webber ◽  
J. Martin ◽  
S. Ormerod ◽  
A. Chesley ◽  
...  
Keyword(s):  
Bone Density ◽  
Bone Mineral ◽  
Cross Sectional Area ◽  
Whole Body ◽  
Control Group ◽  
Dual Photon Absorptiometry ◽  
Sectional Area ◽  
Mineral Density ◽  
Cross Sectional ◽  
Density Measurements

Our purpose was to investigate the relationship between running volume and bone mineral mass in adult male runners. Whole body and regional bone mineral density were determined by dual-photon absorptiometry in 22 sedentary controls and 53 runners who were selected according to their running mileage to fall into a 5- to 10-, 15- to 20-, 25- to 30-, 40- to 55-, or 60- to 75-mile/wk group. All groups were of similar age (20–45 yr) and nutritional status, as determined by 7-day food records. Regional sites for bone density measurements included the trunk, spine, pelvis, thighs, and lower legs. In addition, serum total testosterone was determined in each subject and computed tomography scans were made of the lower legs in 34 subjects to assess bone cross-sectional area. No significant differences were detected for bone density measurements with the exception of the lower legs where it was significantly (P less than 0.05) greater for the 15- to 20-mile/wk group than for the control and 5- to 10-mile/wk groups. With mileage greater than 20 miles/wk, bone density of the lower legs showed no further increase and, in fact, tended to decrease, so that for the 60- to 75-mile/wk group it was similar to that of the controls. Cross-sectional area of the tibia and fibula when normalized to body weight tended to be greater as weekly mileage increased and was significantly greater in the 40- to 55-mile/wk runners than in the control group.(ABSTRACT TRUNCATED AT 250 WORDS)

Hormone replacement therapy increases isometric muscle strength of adductor pollicis in post-menopausal women

1999 ◽  
Vol 96 (4) ◽  
pp. 357-364 ◽  
Author(s):  
D. A. SKELTON ◽  
S. K. PHILLIPS ◽  
S. A. BRUCE ◽  
C. H. NAYLOR ◽  
R. C. WOLEDGE
Keyword(s):  
Bone Mineral Density ◽  
Muscle Strength ◽  
Bone Mineral ◽  
Hormone Replacement ◽  
Treated Group ◽  
Control Group ◽  
Sectional Area ◽  
Mineral Density ◽  
Cross Sectional ◽  
Post Menopausal

A randomized open trial of hormone replacement therapy was used to assess changes in adductor pollicis muscle strength during 6–12 months of treatment with Prempak C 0.625® in comparison with an untreated control group. Muscle strength (maximal voluntary force; MVF), muscle cross-sectional area and bone mineral density were measured. Women entering the trial had oestrogen levels below 150 pmolċl-1, confirming their post-menopausal hormonal status. In the treated group, MVF increased by 12.4±1.0% (mean±S.E.M.) of initial MVF over the duration of treatment, while it declined slightly (2.9±0.9%) in the control group. This increase in strength could not be explained by an increase in muscle bulk, there being no significant increase in cross-sectional area during the study. Those subjects who were weakest at enrolment showed the greatest increases in muscle strength after treatment. Bone mineral density in total hip, Ward's triangle and total spine increased in the treated group, in agreement with previous studies. There was no correlation between the individual increases in bone mineral density and those in MVF.

scholarly journals Genetic and environmental influences on skeletal muscle phenotypes as a function of age and sex in large, multigenerational families of African heritage

2007 ◽  
Vol 103 (4) ◽  
pp. 1121-1127 ◽  
Author(s):  
Steven J. Prior ◽  
Stephen M. Roth ◽  
Xiaojing Wang ◽  
Candace Kammerer ◽  
Iva Miljkovic-Gacic ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Lean Mass ◽  
Genetic Correlations ◽  
Cross Sectional Area ◽  
Calf Muscle ◽  
Sectional Area ◽  
Cross Sectional ◽  
African Heritage ◽  
Genetic Components ◽  
Muscle Cross Sectional Area

The aim of this study was to estimate the heritability of and environmental contributions to skeletal muscle phenotypes (appendicular lean mass and calf muscle cross-sectional area) in subjects of African descent and to determine whether heritability estimates are impacted by sex or age. Body composition was measured by dual-energy X-ray absorptiometry and computed tomography in 444 men and women aged 18 yr and older (mean: 43 yr) from eight large, multigenerational Afro-Caribbean families (family size range: 21–112). Using quantitative genetic methods, we estimated heritability and the association of anthropometric, lifestyle, and medical variables with skeletal muscle phenotypes. In the overall group, we estimated the heritability of lean mass and calf muscle cross-sectional area (h2 = 0.18–0.23, P < 0.01) and contribution of environmental factors to these phenotypes ( r2 = 0.27–0.55, P < 0.05). In our age-specific analysis, the heritability of leg lean mass was lower in older vs. younger individuals (h2 = 0.05 vs. 0.23, respectively, P = 0.1). Sex was a significant covariate in our models ( P < 0.001), although sex-specific differences in heritability varied depending on the lean mass phenotype analyzed. High genetic correlations (ρG = 0.69–0.81; P < 0.01) between different lean mass measures suggest these traits share a large proportion of genetic components. Our results demonstrate the heritability of skeletal muscle traits in individuals of African heritage and that heritability may differ as a function of sex and age. As the loss of skeletal muscle mass is related to metabolic abnormalities, disability, and mortality in older individuals, further research is warranted to identify specific genetic loci that contribute to these traits in general and in a sex- and age-specific manner.

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