Treatment with recombinant lubricin attenuates osteoarthritis by positive feedback loop between articular cartilage and subchondral bone in ovariectomized rats

Bone ◽  
2015 ◽  
Vol 74 ◽  
pp. 37-47 ◽  
Author(s):  
Zhuang Cui ◽  
Changpeng Xu ◽  
Xue Li ◽  
Jinqi Song ◽  
Bin Yu
Keyword(s):  
Articular Cartilage ◽  
Subchondral Bone ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Ovariectomized Rats ◽  
Positive Feedback Loop

scholarly journals Defactinib attenuates osteoarthritis by inhibiting positive feedback loop between H-type vessels and MSCs in subchondral bone

2020 ◽  
Vol 24 ◽  
pp. 12-22 ◽  
Author(s):  
Yanjun Hu ◽  
Hangtian Wu ◽  
Ting Xu ◽  
Yutian Wang ◽  
Hanjun Qin ◽  
...  
Keyword(s):  
Subchondral Bone ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Positive Feedback Loop

scholarly journals MEF2C is a new regulator of the human articular chondrocyte phenotype

2018 ◽  
Author(s):  
S. Lazzarano ◽  
C.L. Murphy
Keyword(s):  
Transcription Factors ◽  
Articular Cartilage ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Regulator Gene ◽  
Articular Chondrocyte ◽  
Positive Feedback Loop ◽  
Chondrocyte Phenotype ◽  
Cooperative Activity ◽  
First Time

MEF2C plays a role in diverse tissues, most notably heart, brain, eyes and developing bones. Here we report for the first time that MEF2C is present and active in the permanent articular cartilage in humans which lines and protects our joints throughout life. We show that MEF2C directly targets cartilage master regulator gene SOX9, and SOX9, in turn, regulates MEF2C in a novel positive feedback loop maintaining high expression levels of both transcription factors, and consequently stabilising the articular chondrocyte phenotype and helping prevent hypertrophy and subsequent calcification and vascularisation. We propose that MEF2C and SOX9 may show similar cooperative activity in other tissues, and across a range of adult murine tissues we found co-expression of both transcription factors in cartilage, trachea, brain, eyes and heart. Strikingly, all of these tissues are prone to calcification and further study of MEF2C/SOX9 cooperativity in these organs will be revealing.

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