Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats

Bone ◽  
2014 ◽  
Vol 67 ◽  
pp. 305-313 ◽  
Author(s):  
Marina Stolina ◽  
Denise Dwyer ◽  
Qing-Tian Niu ◽  
Kelly S. Villasenor ◽  
Pam Kurimoto ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Turnover Markers ◽  
Temporal Changes ◽  
Ovariectomized Rats ◽  
Turnover Markers ◽  
Sclerostin Antibody ◽  
Local Expression

Bone Metabolism in the Healing Process of Lumbar Interbody Fusion-Temporal changes of bone turnover markers-

Spine ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ryota Hyakkan ◽  
Masahiro Kanayama ◽  
Masahiko Takahata ◽  
Fumihiro Oha ◽  
Tomoyuki Hashimoto ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Metabolism ◽  
Bone Turnover Markers ◽  
Interbody Fusion ◽  
Healing Process ◽  
Temporal Changes ◽  
Lumbar Interbody Fusion ◽  
Turnover Markers

scholarly journals Ameliorative Effects of Pueraria lobata Extract on Postmenopausal Symptoms through Promoting Estrogenic Activity and Bone Markers in Ovariectomized Rats

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Mi-Ra Lee ◽  
Bohye Kim ◽  
Yongjun Lee ◽  
Soung-Yong Park ◽  
Jae-Hoon Shim ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Protein Expression ◽  
Bone Turnover Markers ◽  
Ovariectomized Rats ◽  
Type I ◽  
Pueraria Lobata ◽  
Postmenopausal Symptoms ◽  
Ovx Rats ◽  
Long Term Treatment ◽  
Turnover Markers

Pueraria lobata (Willd.) Ohwi, known as kudzu, is one of the most popular traditional medicines in Asian countries. It has been widely used as a natural alternative to hormone replacement therapy for treating postmenopausal symptoms. This study aimed to investigate the estrogenic effect of P. lobata extract (PE) against postmenopausal osteoporosis in ovariectomized (OVX) rats. OVX rats were treated with PE (25–1600 mg/kg) for 8 weeks. Biochemical parameters, estradiol, and bone turnover markers (e.g., osteocalcin, C-terminal telopeptide fragment of type I collagen, deoxypyridinoline, and pyridinoline) were measured in plasma samples. In addition, estrogen receptor-alpha (ER-α) protein expression and morphology of uterine were evaluated. Long-term treatment with PE did not cause liver damage in OVX rats. PE supplementation reduced body weight gain in obese rats with high lipid accumulation induced by ovariectomy. Furthermore, PE exhibited a protective effect against insulin resistance, hyperlipidemia, and hepatic lipid peroxidation. PE treatment increased uterine weight and thickness of the uterine layers in cases of uterus atrophy due to removal of ovaries. The levels of bone turnover markers, which were significantly increased in OVX rats, were decreased by PE treatment. Western blotting analysis showed that ER-α protein expression was upregulated in PE-treated rats compared with OVX rats. These results suggest that PE could be a promising alternative functional food for improving menopausal symptoms.

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