scholarly journals Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency

Bone ◽  
2014 ◽  
Vol 66 ◽  
pp. 146-154 ◽  
Author(s):  
Jinhu Xiong ◽  
Marilina Piemontese ◽  
Jeff D. Thostenson ◽  
Robert S. Weinstein ◽  
Stavros C. Manolagas ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Dietary Calcium ◽  
Calcium Deficiency ◽  
Dietary Calcium Deficiency

scholarly journals The RANKL Distal Control Region Is Required for the Increase in RANKL Expression, But Not the Bone Loss, Associated with Hyperparathyroidism or Lactation in Adult Mice

2012 ◽  
Vol 26 (2) ◽  
pp. 341-348 ◽  
Author(s):  
Melda Onal ◽  
Carlo Galli ◽  
Qiang Fu ◽  
Jinhu Xiong ◽  
Robert S. Weinstein ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Bone Loss ◽  
Control Region ◽  
Dominant Role ◽  
Dietary Calcium ◽  
Calcium Deficiency ◽  
Wild Type ◽  
Rankl Expression ◽  
Adult Mice ◽  
Dietary Calcium Deficiency

Abstract Osteoclast-mediated bone resorption plays an essential role in calcium homeostasis and lactation. The cytokine receptor activator of nuclear factor κB ligand (RANKL) is one of a number of factors that controls the production, survival, and activity of osteoclasts. Calciotropic hormones, such as PTH, control RANKL transcription in part via an enhancer known as the distal control region (DCR), and mice lacking this enhancer have fewer osteoclasts under normal physiological conditions. Here, we have addressed the role of the DCR in situations in which activation of the PTH receptor is thought to stimulate bone resorption via elevation of RANKL expression. Dietary calcium deficiency stimulated RANKL expression in the bone of young (1 month old) wild-type, but not DCR knockout (KO), mice. Consistent with this, the cancellous bone loss and the increase in osteoclasts caused by dietary calcium deficiency were blunted in young KO mice. DCR deletion also prevented the increase in RANKL expression caused by dietary calcium deficiency in 6-month-old mice. However, the diet-induced bone loss was similar in wild-type and KO mice at this age. The increase in RANKL expression caused by lactation was also blunted in DCR KO mice, but lactation-induced bone loss was similar in both genotypes. These results demonstrate that, even though the DCR is required for the increase in RANKL expression associated with hyperparathyroidism or lactation, this increase is not required for the bone loss caused by these conditions in adult mice, suggesting that changes in other factors, such as osteoprotegerin or estrogen levels, play a dominant role.

scholarly journals Accelerated Bone Resorption, Due to Dietary Calcium Deficiency, Promotes Breast Cancer Tumor Growth in Bone

2007 ◽  
Vol 67 (19) ◽  
pp. 9542-9548 ◽  
Author(s):  
Yu Zheng ◽  
Hong Zhou ◽  
James R.K. Modzelewski ◽  
Robert Kalak ◽  
Julie M. Blair ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Resorption ◽  
Tumor Growth ◽  
Dietary Calcium ◽  
Calcium Deficiency ◽  
Cancer Tumor ◽  
Dietary Calcium Deficiency

Skeletal sensitivity to dietary calcium deficiency is increased in the female compared with the male rat

2001 ◽  
Vol 79 (5) ◽  
pp. 379-385 ◽  
Author(s):  
W Geng ◽  
G L Wright
Keyword(s):  
Bone Resorption ◽  
Bone Mass ◽  
Dietary Calcium ◽  
Calcium Deficiency ◽  
Female Rats ◽  
Male Rats ◽  
Male Rat ◽  
Calcium Diet ◽  
Dietary Calcium Deficiency ◽  
Body Bone

We investigated potential sex differences in bone resorption and the conservation of whole body bone mass in 24-week-old Sprague-Dawley rats maintained on a 1.0% calcium diet and then fed diets containing 0.02, 0.5, 1.0, or 1.75% calcium for 31 days. Lowering dietary calcium from 1.00% to 0.02% doubled whole skeleton bone resorption (urinary 3H-tetracycline loss). Female rats were more sensitive to calcium stress, exhibiting the maximal resorptive response when fed the 0.5% calcium diet, whereas the 0.02% calcium diet was required to elicit this response in males. Despite the evidence of increased bone resorption, whole skeleton mass was unchanged in females and was significantly increased in males, indicating that switching to even the 0.02% calcium diet did not result in an overt loss of total body bone mass. Compared with controls, the skeleton mass of females (97 ± 1.4%) maintained on the 0.02% calcium diet was significantly lower than males (107 ± 2.4%), again suggesting a greater impact of calcium deficiency in females. The calculation of the average percentage growth of selected individual bones in male rats indicated a proportional increase in bone mass between the axial and appendicular skeleton of approximately +4% and +18% in animals maintained on 0.02 and 1.75% diets, respectively. By comparison, female rats consuming the 0.02% calcium diet showed an average 14% loss in axial bone and 7.5% gain in appendicular bone mass. The results indicate increased sensitivity to dietary calcium deficiency in female rats which involves a significant loss in axial bone mass not observed in male rats maintained under similar dietary conditions.Key words: skeleton bone mass, calcium diet, 3H-tetracycline, axial, appendicular, gender, sex.

scholarly journals Efficacy of Supplemental Natural Zeolite in Broiler Chickens Subjected to Dietary Calcium Deficiency

2014 ◽  
Vol 13 (2) ◽  
pp. 3141 ◽  
Author(s):  
Erol Bintaş ◽  
Mehmet Bozkurt ◽  
Kamil Küçükyılmaz ◽  
Ramazan Konak ◽  
Mustafa Çınar ◽  
...  
Keyword(s):  
Natural Zeolite ◽  
Broiler Chickens ◽  
Dietary Calcium ◽  
Calcium Deficiency ◽  
Dietary Calcium Deficiency

scholarly journals Elevation of blood pressure in the rat after dietary calcium deficiency

1987 ◽  
Vol 43 ◽  
pp. 291
Author(s):  
Akifuml Toqari ◽  
Takahiro Shamoto ◽  
Michitsugu Arai ◽  
Shosei Matsumoto
Keyword(s):  
Blood Pressure ◽  
Dietary Calcium ◽  
Calcium Deficiency ◽  
Dietary Calcium Deficiency
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