Osteoclast progenitor cells present in significant amounts in mouse calvarial osteoblast isolations and osteoclastogenesis increased by BMP-2

Bone ◽  
2013 ◽  
Vol 52 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Susanne Granholm ◽  
Petra Henning ◽  
Catharina Lindholm ◽  
Ulf H. Lerner
Keyword(s):  
Progenitor Cells ◽  
Osteoclast Progenitor ◽  
Calvarial Osteoblast

scholarly journals Chemokine signals are crucial for enhanced homing and differentiation of circulating osteoclast progenitor cells

2017 ◽  
Vol 19 (1) ◽  
Author(s):  
Alan Sucur ◽  
Zrinka Jajic ◽  
Marinko Artukovic ◽  
Marina Ikic Matijasevic ◽  
Branimir Anic ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Osteoclast Progenitor

scholarly journals AB0026 Chemokine signals are critical for homing and enhanced differentiation of circulating osteoclast progenitor cells

2017 ◽  
Author(s):  
A Sucur ◽  
Z Jajic ◽  
M Artukovic ◽  
M Ikic Matijasevic ◽  
F Grubisic ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Osteoclast Progenitor

Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependent mechanism

2014 ◽  
Vol 87 ◽  
pp. 99-112 ◽  
Author(s):  
Laura Gambari ◽  
Gina Lisignoli ◽  
Luca Cattini ◽  
Cristina Manferdini ◽  
Andrea Facchini ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Sodium Hydrosulfide ◽  
Osteoclast Progenitor ◽  
Dependent Mechanism

scholarly journals Ablation of Gsα signaling in osteoclast progenitor cells adversely affects skeletal bone maintenance

Bone ◽  
2018 ◽  
Vol 109 ◽  
pp. 86-90 ◽  
Author(s):  
Girish Ramaswamy ◽  
John Fong ◽  
Niambi Brewer ◽  
Hyunsoo Kim ◽  
Deyu Zhang ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Bone Maintenance ◽  
Osteoclast Progenitor ◽  
Skeletal Bone

scholarly journals Cell Sources for Human In vitro Bone Models

2021 ◽  
Author(s):  
Sana Ansari ◽  
Keita Ito ◽  
Sandra Hofmann
Keyword(s):  
Bone Marrow ◽  
Progenitor Cells ◽  
Peripheral Blood ◽  
Cell Types ◽  
Medium Composition ◽  
Differentiation Potential ◽  
Osteoclast Progenitor ◽  
Proliferation And Differentiation ◽  
Cell Sources

Abstract Purpose of Review One aim in bone tissue engineering is to develop human cell-based, 3D in vitro bone models to study bone physiology and pathology. Due to the heterogeneity of cells among patients, patient’s own cells are needed to be obtained, ideally, from one single cell source. This review attempts to identify the appropriate cell sources for development of such models. Recent Findings Bone marrow and peripheral blood are considered as suitable sources for extraction of osteoblast/osteocyte and osteoclast progenitor cells. Recent studies on these cell sources have shown no significant differences between isolated progenitor cells. However, various parameters such as medium composition affect the cell’s proliferation and differentiation potential which could make the peripheral blood-derived stem cells superior to the ones from bone marrow. Summary Peripheral blood can be considered a suitable source for osteoblast/osteocyte and osteoclast progenitor cells, being less invasive for the patient. However, more investigations are needed focusing on extraction and differentiation of both cell types from the same donor sample of peripheral blood.

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