scholarly journals Relating micromechanical properties and mineral densities in severely suppressed bone turnover patients, osteoporotic patients, and normal subjects

Bone ◽  
2012 ◽  
Vol 51 (1) ◽  
pp. 114-122 ◽  
Author(s):  
Crystal K. Tjhia ◽  
Susan M. Stover ◽  
D. Sudhaker Rao ◽  
Clarita V. Odvina ◽  
David P. Fyhrie
Keyword(s):  
Bone Turnover ◽  
Normal Subjects ◽  
Micromechanical Properties ◽  
Severely Suppressed Bone Turnover

scholarly journals Mechanical property and tissue mineral density differences among severely suppressed bone turnover (SSBT) patients, osteoporotic patients, and normal subjects

Bone ◽  
2011 ◽  
Vol 49 (6) ◽  
pp. 1279-1289 ◽  
Author(s):  
Crystal K. Tjhia ◽  
Clarita V. Odvina ◽  
D. Sudhaker Rao ◽  
Susan M. Stover ◽  
Xiang Wang ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Bone Turnover ◽  
Normal Subjects ◽  
Mineral Density ◽  
Tissue Mineral Density ◽  
Severely Suppressed Bone Turnover

scholarly journals Severely Suppressed Bone Turnover: A Potential Complication of Alendronate Therapy

2005 ◽  
Vol 90 (3) ◽  
pp. 1294-1301 ◽  
Author(s):  
Clarita V. Odvina ◽  
Joseph E. Zerwekh ◽  
D. Sudhaker Rao ◽  
Naim Maalouf ◽  
Frank A. Gottschalk ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Potential Complication ◽  
Severely Suppressed Bone Turnover

scholarly journals Treatment strategy for atypical ulnar fracture due to severely suppressed bone turnover caused by long-term bisphosphonate therapy: a case report and literature review

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Kensaku Abe ◽  
Hiroaki Kimura ◽  
Norio Yamamoto ◽  
Shingo Shimozaki ◽  
Takashi Higuchi ◽  
...  
Keyword(s):  
Literature Review ◽  
Bone Turnover ◽  
Bone Graft ◽  
Treatment Strategy ◽  
Bisphosphonate Therapy ◽  
Bone Union ◽  
Atypical Fracture ◽  
Dual Plate ◽  
Severely Suppressed Bone Turnover

Abstract Background Atypical fractures may occur due to the combined effect of severely suppressed bone turnover (SSBT) caused by long-term bisphosphonate treatment and chronic repetitive bone microdamage. Atypical fracture of the ulna due to SSBT is a rare entity; there is no standardized treatment strategy for this condition. We successfully treated a patient with atypical fracture of the ulna. Herein, we present this patient, review the relevant literature, and discuss the treatment strategy. Case presentation An 84-year-old woman presented with atypical fracture of the left ulnar shaft due to SSBT. She had a history of bisphosphonate therapy (ibandronate and alendronate) since more than 10 years; her bone turnover was severely suppressed. We performed open reduction and internal fixation (ORIF) using dual plate with some additional treatments. These included drilling and decortication, use of autogenous bone graft, low-intensity pulsed ultrasound (LIPUS) treatment, and administration of teriparatide. Finally, bone union was observed at 11 months after surgery. Conclusions Based on the literature review and our experience with this case, ORIF alone may not be adequate to achieve bone union; drilling, decortication, and use of cancellus bone graft is important to achieve favorable outcomes. Administration of teriparatide and LIPUS may facilitate early bone union, although further studies are required to provide more definitive evidence. Furthermore, ORIF using dual plate may help avoid implant failure owing to the long time required for bone union.

scholarly journals Correction to: Treatment strategy for atypical ulnar fracture due to severely suppressed bone turnover caused by long-term bisphosphonate therapy: a case report and literature review

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Kensaku Abe ◽  
Hiroaki Kimura ◽  
Norio Yamamoto ◽  
Shingo Shimozaki ◽  
Takashi Higuchi ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Bone Turnover ◽  
Treatment Strategy ◽  
Bisphosphonate Therapy ◽  
Ulnar Fracture ◽  
Severely Suppressed Bone Turnover

An amendment to this paper has been published and can be accessed via the original article.

scholarly journals Severely Suppressed Bone Turnover and Atypical Skeletal Fragility

2008 ◽  
Vol 93 (8) ◽  
pp. 2948-2952 ◽  
Author(s):  
Maja Visekruna ◽  
Deborah Wilson ◽  
Fergus Eoin McKiernan
Keyword(s):  
Bone Turnover ◽  
Skeletal Fragility ◽  
Severely Suppressed Bone Turnover

BONE HISTOLOGY OF PATIENTS WITH ALENDRONATE-MEDIATED FRACTURED BONE — A NEW ENTITY OF ATYPICAL OSTEOMALACIA

2014 ◽  
Vol 17 (03) ◽  
pp. 1450011
Author(s):  
Myung-Sang Moon ◽  
Ki-Tae Kwon ◽  
Chang-Won Ha ◽  
Sung-Soo Kim ◽  
Sung Sim Kim ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Bone Disease ◽  
Endocrine System ◽  
Bone Fragility ◽  
Bisphosphonate Therapy ◽  
Bone Diseases ◽  
Drug Induced ◽  
Metabolic Turnover ◽  
Severely Suppressed Bone Turnover

Based on the pharmaco-physiology of the aminobisphosphonates, it could be speculated that bisphosphonates could induce not only the osteopetrotic bone disease because of their selective suppression of osteoclastic activity, but also could affect directly or indirectly the endocrine system, local factors, and also the bone metabolic turnover. Consequently, the bone fragility could be rather produced by long-term aminobisphosphonate therapy. Bisphosphonate-mediated bone disease was labeled by Odvina et al. in 2005 [Odvina CV, Zerwerth JE, Rao DS et al. Severely suppressed bone turnover; a potential complication of alendronate therapy. J Clin Endocrinol Metab 90: 1294–1301, 2005.] as the "severely suppressed bone turnover (SSBT)" on the metabolic turnover basis. However, such definition could contain various drug-induced bone diseases, and did not indicate any particular condition, induced by the bisphosphonate. The term "SSBT" is thought not solely to be based on its histology, and seems rather a clinical term applicable to the various drug-induced bone diseases. Therefore, the current authors attempted to characterize the bisphosphonate-mediated bone disease on the basis of the combined image and histological studies, and finally concluded that the prolonged bisphosphonate therapy could produce an atypical osteomalacic bone disease. (osteosclerosis of osteomalacia) which leads to fragility fracture. It is puzzling as to why malacia rather than petrosis develops in the skeleton.

Auditory Selective Attention in Cerebral-Palsied Individuals

1985 ◽  
Vol 16 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Lee Ann Laraway
Keyword(s):  
Selective Attention ◽  
White Noise ◽  
Normal Subjects ◽  
Auditory Selective Attention ◽  
Normal Individuals ◽  
Significant Difference

The purpose of this study was to determine whether there is a statistically significant difference between the auditory selective attention abilities of normal and cerebral-palsied individuals. Twenty-three cerebral-palsied and 23 normal subjects between the ages of 5 and 21 were asked to repeat a series of 30 items consisting of from 2 to 4 digits in the presence of intermittent white noise. Results of the study indicate that cerebral-palsied individuals perform significantly poorer than normal individuals when the stimulus is accompanied by noise. Noise was not a significant factor in the performance of the normal subjects regardless of age.

The Effect of Stapedectomy on the Loudness of One’s Own Voice

1965 ◽  
Vol 8 (3) ◽  
pp. 223-234 ◽  
Author(s):  
William Melnick
Keyword(s):  
Middle Ear ◽  
Normal Subjects ◽  
Sound Energy ◽  
Loudness Function ◽  
Before And After ◽  
Increased Sensitivity

Five subjects with normal middle ear mechanisms, and otosclerotic patients, before and after stapedectomy, matched the loudness of their voices to the loudness of a 125-cps-sawtooth noise. The results showed loudness matching functions with gradual slopes, less than 1.00, for the normal subjects and the patients prior to stapedectomy. Post-surgically, the loudness function for the patients increased in steepness to considerably more than 1.00. These results are explained, most logically, in terms of increased sensitivity of the altered middle ear to sound energy generated by the listener’s own voice.

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