Proteinase-activated receptor-2 is required for normal osteoblast and osteoclast differentiation during skeletal growth and repair

Bone ◽  
2012 ◽  
Vol 50 (3) ◽  
pp. 704-712 ◽  
Author(s):  
S.R. Georgy ◽  
C.N. Pagel ◽  
A. Ghasem-Zadeh ◽  
R.M.D. Zebaze ◽  
R.N. Pike ◽  
...  
Keyword(s):  
Osteoclast Differentiation ◽  
Skeletal Growth ◽  
Normal Osteoblast

Osteoblastic ephrinB2 is required for normal osteoblast and osteoclast differentiation

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S65 ◽  
Author(s):  
F.M. Takyar ◽  
B. Crimeen-Irwin ◽  
T.J. Martin ◽  
N.A. Sims
Keyword(s):  
Osteoclast Differentiation ◽  
Normal Osteoblast

Skeletal growth of four scleractinian corals is not enhanced by in situ mesozooplankton enrichment

2013 ◽  
Vol 489 ◽  
pp. 143-153 ◽  
Author(s):  
AL Alldredge ◽  
SJ Holbrook ◽  
RJ Schmitt ◽  
AJ Brooks ◽  
H Stewart
Keyword(s):  
Scleractinian Corals ◽  
Skeletal Growth

The Impact of Proinflammatory Cytokynes of Rheumatoid Polyarthritis on the Generalized Loss of Bone Mass

2018 ◽  
Vol 69 (9) ◽  
pp. 2541-2545
Author(s):  
Raluca Barzoi ◽  
Elena Rezus ◽  
Codruta Badescu ◽  
Razan Al Namat ◽  
Manuela Ciocoiu
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune Cells ◽  
Osteoclast Differentiation ◽  
Bone Destruction ◽  
Nuclear Factor ◽  
Receptor Activator ◽  
Level Function ◽  
Rheumatoid Polyarthritis ◽  
The Impact ◽  
Nuclear Factor Kb

There is a bidirectional interaction between most immune cells and osteoblasts, osteoclasts and their precursor cells. The receptor activator of nuclear factor-kB ligand (RANKL)/RANK/osteoprotegerin (OPG) system plays an essential role in the formation of osteoblasts, but it also has implications in osteoclast biology and implicitly on the diseases characterized by bone loss. Proinflammatory cytokines existing at synovial level function as direct or indirect stimulators of osteoclast differentiation, but also of its survival or activity, although some cytokines may also play an antiosteocastogenic role. The fate of bone destruction is determined by the balance between osteoclastogenic and antiosteoclastogenic mediators. Our study has shown that the early initiation of the therapy with anti-TNF and anti-IL6 biological agents, in patients with rheumatoid arthritis, inhibits bone destruction, regardless of the anti-inflammatory activity in patients with rheumatoid arthritis.

Syndecan 4 contributes to osteoclast differentiation induced by RANKL through enhancing autophagy

2021 ◽  
Vol 91 ◽  
pp. 107275
Author(s):  
Ji Li ◽  
Ziquan Sun ◽  
Yu Lin ◽  
Yan Yan ◽  
Haichao Yan ◽  
...  
Keyword(s):  
Osteoclast Differentiation
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