scholarly journals Influence of pre- and peri-natal nutrition on skeletal acquisition and maintenance

Bone ◽  
2012 ◽  
Vol 50 (2) ◽  
pp. 444-451 ◽  
Author(s):  
M.J. Devlin ◽  
M.L. Bouxsein
Keyword(s):  
Skeletal Acquisition

scholarly journals Daily leptin blunts marrow fat but does not impact bone mass in calorie-restricted mice

2016 ◽  
Vol 229 (3) ◽  
pp. 295-306 ◽  
Author(s):  
M J Devlin ◽  
D J Brooks ◽  
C Conlon ◽  
M van Vliet ◽  
L Louis ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Mass ◽  
Body Mass ◽  
Body Fat ◽  
Whole Body ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Marrow Fat ◽  
Bone Marrow Fat ◽  
Skeletal Acquisition

Starvation induces low bone mass and high bone marrow adiposity in humans, but the underlying mechanisms are poorly understood. The adipokine leptin falls in starvation, suggesting that hypoleptinemia may be a link between negative energy balance, bone marrow fat accumulation, and impaired skeletal acquisition. In that case, treating mice with leptin during caloric restriction (CR) should reduce marrow adipose tissue (MAT) and improve bone mass. To test this hypothesis, female C57Bl/6J mice were fed a 30% CR or normal (N) diet from 5 to 10 weeks of age, with daily injections of vehicle (VEH), 1mg/kg leptin (LEP1), or 2mg/kg leptin (LEP2) (N=6–8/group). Outcomes included body mass, body fat percentage, and whole-body bone mineral density (BMD) via peripheral dual-energy X-ray absorptiometry, cortical and trabecular microarchitecture via microcomputed tomography (μCT), and MAT volume via μCT of osmium tetroxide-stained bones. Overall, CR mice had lower body mass, body fat percentage, BMD, and cortical bone area fraction, but more connected trabeculae, vs N mice (P<0.05 for all). Most significantly, although MAT was elevated in CR vs N overall, leptin treatment blunted MAT formation in CR mice by 50% vs VEH (P<0.05 for both leptin doses). CR LEP2 mice weighed less vs CR VEH mice at 9–10 weeks of age (P<0.05), but leptin treatment did not affect body fat percentage, BMD, or bone microarchitecture within either diet. These data demonstrate that once daily leptin bolus during CR inhibits bone marrow adipose expansion without affecting bone mass acquisition, suggesting that leptin has distinct effects on starvation-induced bone marrow fat formation and skeletal acquisition.

scholarly journals Differential effects of high fat diet and diet-induced obesity on skeletal acquisition in female C57BL/6J vs. FVB/NJ Mice

Bone Reports ◽  
2018 ◽  
Vol 8 ◽  
pp. 204-214 ◽  
Author(s):  
M.J. Devlin ◽  
A. Robbins ◽  
M.N. Cosman ◽  
C.A. Moursi ◽  
A.M. Cloutier ◽  
...  
Keyword(s):  
High Fat Diet ◽  
High Fat ◽  
Differential Effects ◽  
Diet Induced Obesity ◽  
Skeletal Acquisition

scholarly journals Early-Onset Type 2 Diabetes Impairs Skeletal Acquisition in the Male TALLYHO/JngJ Mouse

Endocrinology ◽  
2014 ◽  
Vol 155 (10) ◽  
pp. 3806-3816 ◽  
Author(s):  
M. J. Devlin ◽  
M. Van Vliet ◽  
K. Motyl ◽  
L. Karim ◽  
D. J. Brooks ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Bone Marrow ◽  
Bone Mass ◽  
Early Onset ◽  
Volume Fraction ◽  
Mineral Density ◽  
Bone Volume Fraction ◽  
Skeletal Acquisition

Abstract Type 2 diabetes (T2D) incidence in adolescents is rising and may interfere with peak bone mass acquisition. We tested the effects of early-onset T2D on bone mass, microarchitecture, and strength in the TALLYHO/JngJ mouse, which develops T2D by 8 weeks of age. We assessed metabolism and skeletal acquisition in male TALLYHO/JngJ and SWR/J controls (n = 8–10/group) from 4 weeks to 8 and 17 weeks of age. Tallyho mice were obese; had an approximately 2-fold higher leptin and percentage body fat; and had lower bone mineral density vs SWR at all time points (P &lt; .03 for all). Tallyho had severe deficits in distal femur trabecular bone volume fraction (−54%), trabecular number (−27%), and connectivity density (−82%) (P &lt; .01 for all). Bone formation was higher in Tallyho mice at 8 weeks but lower by 17 weeks of age vs SWR despite similar numbers of osteoblasts. Bone marrow adiposity was 7- to 50-fold higher in Tallyho vs SWR. In vitro, primary bone marrow stromal cell differentiation into osteoblast and adipocyte lineages was similar in SWR and Tallyho, suggesting skeletal deficits were not due to intrinsic defects in Tallyho bone-forming cells. These data suggest the Tallyho mouse might be a useful model to study the skeletal effects of adolescent T2D.

scholarly journals Serum IGF-1 Affects Skeletal Acquisition in a Temporal and Compartment-Specific Manner

PLoS ONE ◽  
2011 ◽  
Vol 6 (3) ◽  
pp. e14762 ◽  
Author(s):  
Hayden-William Courtland ◽  
Sebastien Elis ◽  
Yingjie Wu ◽  
Hui Sun ◽  
Clifford J. Rosen ◽  
...  
Keyword(s):  
Specific Manner ◽  
Skeletal Acquisition

scholarly journals VDR Haploinsufficiency Impacts Body Composition and Skeletal Acquisition in a Gender-Specific Manner

2011 ◽  
Vol 89 (3) ◽  
pp. 179-191 ◽  
Author(s):  
Francisco J. A. de Paula ◽  
Ingrid Dick-de-Paula ◽  
Sheila Bornstein ◽  
Bahman Rostama ◽  
Phuong Le ◽  
...  
Keyword(s):  
Body Composition ◽  
Specific Manner ◽  
Gender Specific ◽  
Skeletal Acquisition
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