Denosumab, a fully human RANKL antibody, reduced bone turnover markers and increased trabecular and cortical bone mass, density, and strength in ovariectomized cynomolgus monkeys

Bone ◽  
2011 ◽  
Vol 49 (2) ◽  
pp. 162-173 ◽  
Author(s):  
Michael S. Ominsky ◽  
Brian Stouch ◽  
Joseph Schroeder ◽  
Ian Pyrah ◽  
Marina Stolina ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Cortical Bone ◽  
Bone Turnover Markers ◽  
Mass Density ◽  
Bone Mass Density ◽  
Cynomolgus Monkeys ◽  
Turnover Markers ◽  
Cortical Bone Mass

scholarly journals Correlations between bone turnover markers, serum magnesium and bone mass density in postmenopausal osteoporosis

2018 ◽  
Vol Volume 13 ◽  
pp. 1383-1389 ◽  
Author(s):  
Ovidiu Alexandru Mederle ◽  
Melania Balas ◽  
Sorin Dumitru Ioanoviciu ◽  
Camelia-Vidita Gurban ◽  
Anca Tudor ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Postmenopausal Osteoporosis ◽  
Bone Turnover Markers ◽  
Mass Density ◽  
Serum Magnesium ◽  
Bone Mass Density ◽  
Turnover Markers

scholarly journals Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss

2015 ◽  
Vol 227 (3) ◽  
pp. 129-141 ◽  
Author(s):  
Russell T Turner ◽  
Michael Dube ◽  
Adam J Branscum ◽  
Carmen P Wong ◽  
Dawn A Olson ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Body Weight ◽  
Bone Loss ◽  
Bone Mass ◽  
Bone Turnover ◽  
Cancellous Bone ◽  
Mass Density ◽  
Female Rats ◽  
Bone Mass Density ◽  
Age Related

Excessive weight gain in adults is associated with a variety of negative health outcomes. Unfortunately, dieting, exercise, and pharmacological interventions have had limited long-term success in weight control and can result in detrimental side effects, including accelerating age-related cancellous bone loss. We investigated the efficacy of using hypothalamic leptin gene therapy as an alternative method for reducing weight in skeletally-mature (9 months old) female rats and determined the impact of leptin-induced weight loss on bone mass, density, and microarchitecture, and serum biomarkers of bone turnover (CTx and osteocalcin). Rats were implanted with cannulae in the 3rd ventricle of the hypothalamus and injected with either recombinant adeno-associated virus encoding the gene for rat leptin (rAAV-Leptin,n=7) or a control vector encoding green fluorescent protein (rAAV-GFP,n=10) and sacrificed 18 weeks later. A baseline control group (n=7) was sacrificed at vector administration. rAAV-Leptin-treated rats lost weight (−4±2%) while rAAV-GFP-treated rats gained weight (14±2%) during the study. At study termination, rAAV-Leptin-treated rats weighed 17% less than rAAV-GFP-treated rats and had lower abdominal white adipose tissue weight (−80%), serum leptin (−77%), and serum IGF1 (−34%). Cancellous bone volume fraction in distal femur metaphysis and epiphysis, and in lumbar vertebra tended to be lower (P<0.1) in rAAV-GFP-treated rats (13.5 months old) compared to baseline control rats (9 months old). Significant differences in cancellous bone or biomarkers of bone turnover were not detected between rAAV-Leptin and rAAV-GFP rats. In summary, rAAV-Leptin-treated rats maintained a lower body weight compared to baseline and rAAV-GFP-treated rats with minimal effects on bone mass, density, microarchitecture, or biochemical markers of bone turnover.

Sex Steroids, Bone Mass and Bone Turnover Markers in Asian Indians

2014 ◽  
Vol 17 (3) ◽  
pp. 413
Author(s):  
M.P. Desai ◽  
K. Venkat ◽  
K. V. Bhanu Prakash ◽  
M. Khatkhatay
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Sex Steroids ◽  
Bone Turnover Markers ◽  
Asian Indians ◽  
Turnover Markers

Relationship Among VDR (BsmI and FokI), COLIA1, and CTR Polymorphisms with Bone Mass, Bone Turnover Markers, and Sex Hormones in Men

2002 ◽  
Vol 70 (6) ◽  
pp. 457-462 ◽  
Author(s):  
V. Braga ◽  
A. Sangalli ◽  
G. Malerba ◽  
M. Mottes ◽  
S. Mirandola ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Sex Hormones ◽  
Bone Turnover Markers ◽  
Turnover Markers

Low Bone Mass in Thalassemia: The Thalassemia Clinical Research Network (TCRN) Experience.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3613-3613
Author(s):  
Maria G. Vogiatzi ◽  
Joseph Lane ◽  
Martin Fleisher ◽  
Eric A. Macklin ◽  
Ellen B. Fung ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Bone Disease ◽  
Bone Turnover Markers ◽  
Research Network ◽  
Dietary Calcium Intake ◽  
Low Bone Mass ◽  
Mineral Density ◽  
T Score ◽  
Turnover Markers

Abstract Low bone mass is emerging as a frequent and debilitating morbidity in Thalassemia (thal). The TCRN conducted a cross-sectional observational study to determine the prevalence and factors contributing to bone disease among North American thal patients (pts). Spinal (L1-L4) Bone Mineral Density (BMD) Z- and T-score measurements by DXA (Hologic 4500 and Delphi models) were read centrally. Each subject’s weight, height, hematologic, endocrine and genetic parameters, iron chelation and transfusion regimens, dietary calcium intake, history of fractures and bone pain, self-reported physical activity and bone turnover markers were assessed. BMD was measured in 302 pts: 207 Thal Major (TM), 37 Thal Intermedia (TI), 35 Beta E, 7 Hemoglobin H disease (HbH), 2 homozygous alpha (α) and 14 HbH/Constant Spring (HbH/CS). Among all diagnostic groups, the prevalence of low bone mass (LBM; Z/T <-2), reduced bone mass (RBM; Z/T -2 to -1) and normal bone mass (NBM; Z/T >-1) was 52%, 27% and 21%, respectively. LBM prevalence was 55% in TM, 53% in TI, 51% in Beta E, 0% in HbH, 50% in α and 43% in HbH/CS. RBM prevalence was 26% in TM, 22% in TI, 31% in Beta E, 71% in HbH, 50% in α and 29% in HbH/CS. Pt groups aged: 6–11 yrs, 11–20 yrs, 20+ yrs had Z/T-scores mean±SD[n] were: −1.32±0.82[51], −1.73±1.08[77] and −2.43±1.14[174], respectively. Z/T-scores were significantly lower among older pts (p<.001) and significantly higher among heavier pts after controlling for Tanner stage. Mean age-adjusted Z/T-scores of thal diagnostic groups and their slopes vs. age did not differ significantly although the samples of some groups were small. Among TM and TI pts, those with genotype β°/β° tended to have lower age- and weight-adjusted Z/T-scores (mean [95% CI]: −2.25 [−2.65 to −1.86], n=39). Less than 1% had hypoparathyroidism, 4% vit D deficiency, 8.5% diabetes mellitus, 8.5% hypothyroidism and 11.5% growth hormone deficiency (GHD). Only GHD was significantly correlated with decreased Z/T-scores after controlling for age and diagnosis. Urinary N-telopeptide (NTx) is elevated across all three age groups (median[IQR] mM BCE/mM creatinine: 664[456–930], 302[90–624], 69[34–124]), respectively. Preliminary analysis of bone turnover markers in a subset of subjects (n=114) suggests that NTx, urinary or serum was a significant independent predictor of spine Z/T-scores controlled for age and age-adjusted weight. There was no relationship between Z/T-score and serum osteocalcin. This large and comprehensive study of thal bone disease has demonstrated that decreased bone mass occurs with high frequency, worsens with age, is affected by weight and GHD and is associated with elevated NTx, i.e. increased bone resorption. Future studies are needed to identify efficacious long-term therapies to improve thal bone disease.

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