Women with inadequately controlled type 2 diabetes are at increased risk of osteoporotic fractures despite higher bone mineral density: The Rotterdam study

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S194
Author(s):  
L. Oei ◽  
M. Castano-Betancourt ◽  
H. Pols ◽  
A. Dehghan ◽  
A. Uitterlinden ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Mineral ◽  
Osteoporotic Fractures ◽  
Rotterdam Study ◽  
Mineral Density ◽  
Increased Risk

scholarly journals Fragility fractures and bone remodeling in type 2 diabetes mellitus

2017 ◽  
Vol 14 (3) ◽  
pp. 11-18 ◽  
Author(s):  
Tatiana O. Yalochkina ◽  
Zhanna E. Belaya
Keyword(s):  
Risk Factors ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Tissue ◽  
Bone Mineral ◽  
Bone Fragility ◽  
Mineral Density ◽  
Severe Diabetes ◽  
Increased Risk

Fracture risk is significantly increased in both type 1 and type 2 diabetes and individuals with diabetes experience worse fracture outcomes compared to normoglycemic individuals. Patients with T1DM have decreased bone mineral density (BMD), whereas patients with T2DM demonstrate increased BMD compared to healthy control. The latest studies show increased incidence of low-traumatic fractures in patients with T2DM instead of high bone mineral density (BMD). The risk of osteoporotic fractures in patients with T2DM can be explained by disease complications and increased risk of falls and consequent trauma. However, the most important cause of bone fragility in T2DM is the deterioration in bone microarchitecture, the mechanism of which is not completely understood. High BMD in patients with T2DM does not allow us to use dual-energy X-ray-absorptiometry as a gold standard test for diagnosticsof osteoporosis. Consequently,new risk factors and diagnostic algorithm as well as treatment strategy should be developed for patients with T2DM. In addition to this, some researchers considered that the group of T2DM is geterogenous and physicians might face patients with osteoporosis and mild diabetes that add very little to bone fragility; patients with osteoporosis and moderate or severe diabetes which also affects bone tissue diabetoosteoporosis; and patients without osteoporosis but severe diabetes which cause bone tissue deterioration with the development of diabetic bone disease. New diagnostic tools and algorithm and new experimental research are needed for better understanding bone deterioration in patients with T2DM. This review summarizes our current knowledge on fracture rate, risk factors for fractures and causes of bone deterioration in subjects with T2DM.

scholarly journals Osteoporosis, Fractures, and Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Peter Jackuliak ◽  
Juraj Payer
Keyword(s):  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Bone Mass ◽  
Bone Mineral ◽  
Bone Fractures ◽  
Trabecular Bone Score ◽  
Bone Fragility ◽  
Mineral Density ◽  
Increased Risk

It is well established that osteoporosis and diabetes are prevalent diseases with significant associated morbidity and mortality. Patients with diabetes mellitus have an increased risk of bone fractures. In type 1 diabetes, the risk is increased by ∼6 times and is due to low bone mass. Despite increased bone mineral density (BMD), in patients with type 2 diabetes the risk is increased (which is about twice the risk in the general population) due to the inferior quality of bone. Bone fragility in type 2 diabetes, which is not reflected by bone mineral density, depends on bone quality deterioration rather than bone mass reduction. Thus, surrogate markers and examination methods are needed to replace the insensitivity of BMD in assessing fracture risks of T2DM patients. One of these methods can be trabecular bone score. The aim of the paper is to present the present state of scientific knowledge about the osteoporosis risk in diabetic patient. The review also discusses the possibility of problematic using the study conclusions in real clinical practice.

Bone mineral density and fracture risk in type-2 diabetes mellitus: the Rotterdam Study.

2005 ◽  
Vol 16 (12) ◽  
pp. 1713-1720 ◽  
Author(s):  
I. I. de Liefde ◽  
M. van der Klift ◽  
C. E. D. H. de Laet ◽  
P. L. A. van Daele ◽  
A. Hofman ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Rotterdam Study ◽  
Mineral Density

Bone mineral density in male patients with type 2 diabetes mellitus, with and without hypogonadism

2017 ◽  
Author(s):  
Agathi Vasileiou ◽  
Ioanna Karathanassi ◽  
Parthena Navrozidou ◽  
Marianna Vlychou ◽  
Georgios Koukoulis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Bone Mineral ◽  
Mineral Density ◽  
Male Patients

scholarly journals Link between vitamin B12, type 2 diabetes mellitus, and bone mineral density in elderly patients

2015 ◽  
Vol 6 (4) ◽  
pp. 120-124 ◽  
Author(s):  
Moatassem S. Amer ◽  
Randa Ali-Labib ◽  
Tamer M. Farid ◽  
Doha Rasheedy ◽  
Mohammad F. Tolba
Keyword(s):  
Diabetes Mellitus ◽  
Bone Mineral Density ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Elderly Patients ◽  
Vitamin B12 ◽  
Bone Mineral ◽  
Mineral Density
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