The role of nuclear factor-E2-related factor 1 in the oxidative stress response in osteoblast cells

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S121
Author(s):  
S.Y. Park ◽  
S.M. Choi ◽  
S.J. Park ◽  
S.-K. Lim
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Oxidative Stress Response ◽  
Related Factor ◽  
Nuclear Factor ◽  
Osteoblast Cells

The Role of Nuclear Factor-E2-Related Factor 1 in Oxidative Stress Response in Osteoblast Cells

2011 ◽  
pp. P1-185-P1-185
Author(s):  
So Young Park ◽  
Seong Mi Choi ◽  
Si Hoon Lee ◽  
Su Jin Park ◽  
Sungkil Lim
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Oxidative Stress Response ◽  
Related Factor ◽  
Nuclear Factor ◽  
Osteoblast Cells

scholarly journals The Role of Nuclear Factor-E2-Related Factor 1 in the Oxidative Stress Response in MC3T3-E1 Osteoblastic Cells

2016 ◽  
Vol 31 (2) ◽  
pp. 336 ◽  
Author(s):  
So Young Park ◽  
Sung Hoon Kim ◽  
Hyun Koo Yoon ◽  
Chang Hoon Yim ◽  
Sung-Kil Lim
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Oxidative Stress Response ◽  
Osteoblastic Cells ◽  
Related Factor ◽  
Nuclear Factor

scholarly journals Increasing Oxygen Partial Pressures Induce a Distinct Transcriptional Response in Human PBMC: A Pilot Study on the “Normobaric Oxygen Paradox”

2021 ◽  
Vol 22 (1) ◽  
pp. 458
Author(s):  
Deborah Fratantonio ◽  
Fabio Virgili ◽  
Alessandro Zucchi ◽  
Kate Lambrechts ◽  
Tiziana Latronico ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Transcription Factors ◽  
Stress Response ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Oxidative Stress Response ◽  
Molecular Characteristics ◽  
Nuclear Factor ◽  
Normobaric Oxygen ◽  
Oxygen Paradox

The term “normobaric oxygen paradox” (NOP), describes the response to the return to normoxia after a hyperoxic event, sensed by tissues as oxygen shortage, and resulting in up-regulation of the Hypoxia-inducible factor 1α (HIF-1α) transcription factor activity. The molecular characteristics of this response have not been yet fully characterized. Herein, we report the activation time trend of oxygen-sensitive transcription factors in human peripheral blood mononuclear cells (PBMCs) obtained from healthy subjects after one hour of exposure to mild (MH), high (HH) and very high (VHH) hyperoxia, corresponding to 30%, 100%, 140% O2, respectively. Our observations confirm that MH is perceived as a hypoxic stress, characterized by the activation of HIF-1α and Nuclear factor (erythroid-derived 2)-like 2 (NRF2), but not Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB). Conversely, HH is associated to a progressive loss of NOP response and to an increase in oxidative stress leading to NRF2 and NF-kB activation, accompanied by the synthesis of glutathione (GSH). After VHH, HIF-1α activation is totally absent and oxidative stress response, accompanied by NF-κB activation, is prevalent. Intracellular GSH and Matrix metallopeptidase 9 (MMP-9) plasma levels parallel the transcription factors activation pattern and remain elevated throughout the observation time. In conclusion, our study confirms that, in vivo, the return to normoxia after MH is sensed as a hypoxic trigger characterized by HIF-1α activation. On the contrary, HH and VHH induce a shift toward an oxidative stress response, characterized by NRF2 and NF-κB activation in the first 24 h post exposure.

scholarly journals Role of ALADIN in Human Adrenocortical Cells for Oxidative Stress Response and Steroidogenesis

PLoS ONE ◽  
2015 ◽  
Vol 10 (4) ◽  
pp. e0124582 ◽  
Author(s):  
Ramona Jühlen ◽  
Jan Idkowiak ◽  
Angela E. Taylor ◽  
Barbara Kind ◽  
Wiebke Arlt ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Oxidative Stress Response ◽  
Adrenocortical Cells

scholarly journals The transcription factor, Nuclear factor, erythroid 2 (Nfe2), is a regulator of the oxidative stress response during Danio rerio development

2016 ◽  
Vol 180 ◽  
pp. 141-154 ◽  
Author(s):  
Larissa M. Williams ◽  
Briony A. Lago ◽  
Andrew G. McArthur ◽  
Amogelang R. Raphenya ◽  
Nicholas Pray ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Transcription Factor ◽  
Stress Response ◽  
Danio Rerio ◽  
Oxidative Stress Response ◽  
Nuclear Factor ◽  
Transcription Factor Nuclear Factor

The role of CSA and CSB protein in the oxidative stress response

2013 ◽  
Vol 134 (5-6) ◽  
pp. 261-269 ◽  
Author(s):  
Mariarosaria D’Errico ◽  
Barbara Pascucci ◽  
Egidio Iorio ◽  
Bennett Van Houten ◽  
Eugenia Dogliotti
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Oxidative Stress Response

scholarly journals TrmB, a tRNA m7G46 methyltransferase, plays a role in hydrogen peroxide resistance and positively modulates the translation of katA and katB mRNAs in Pseudomonas aeruginosa

2019 ◽  
Vol 47 (17) ◽  
pp. 9271-9281 ◽  
Author(s):  
Narumon Thongdee ◽  
Juthamas Jaroensuk ◽  
Sopapan Atichartpongkul ◽  
Jurairat Chittrakanwong ◽  
Kamonchanok Chooyoung ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pseudomonas Aeruginosa ◽  
Stress Response ◽  
Translational Regulation ◽  
Cellular Response ◽  
Oxidative Stress Response ◽  
Translation Efficiency ◽  
Trna Modification ◽  
Negative Effect

Abstract Cellular response to oxidative stress is a crucial mechanism that promotes the survival of Pseudomonas aeruginosa during infection. However, the translational regulation of oxidative stress response remains largely unknown. Here, we reveal a tRNA modification-mediated translational response to H2O2 in P. aeruginosa. We demonstrated that the P. aeruginosa trmB gene encodes a tRNA guanine (46)-N7-methyltransferase that catalyzes the formation of m7G46 in the tRNA variable loop. Twenty-three tRNA substrates of TrmB with a guanosine residue at position 46 were identified, including 11 novel tRNA substrates. We showed that loss of trmB had a strong negative effect on the translation of Phe- and Asp-enriched mRNAs. The trmB-mediated m7G modification modulated the expression of the catalase genes katA and katB, which are enriched with Phe/Asp codons at the translational level. In response to H2O2 exposure, the level of m7G modification increased, consistent with the increased translation efficiency of Phe- and Asp-enriched mRNAs. Inactivation of trmB led to decreased KatA and KatB protein abundance and decreased catalase activity, resulting in H2O2-sensitive phenotype. Taken together, our observations reveal a novel role of m7G46 tRNA modification in oxidative stress response through translational regulation of Phe- and Asp-enriched genes, such as katA and katB.

scholarly journals Basic Concepts on the Role of Nuclear Factor Erythroid-Derived 2-Like 2 (Nrf2) in Age-Related Diseases

2019 ◽  
Vol 20 (13) ◽  
pp. 3208 ◽  
Author(s):  
Fabiane Valentini Francisqueti-Ferron ◽  
Artur Junio Togneri Ferron ◽  
Jéssica Leite Garcia ◽  
Carol Cristina Vágula de Almeida Silva ◽  
Mariane Róvero Costa ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Transcription Factor ◽  
Transcriptional Factor ◽  
Future Research ◽  
Related Factor ◽  
Nuclear Factor ◽  
Nrf2 Pathway ◽  
Age Related ◽  
Basic Concepts

The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) is one of the most important oxidative stress regulator in the human body. Once Nrf2 regulates the expression of a large number of cytoprotective genes, it plays a crucial role in the prevention of several diseases, including age-related disorders. However, the involvement of Nrf2 on these conditions is complex and needs to be clarified. Here, a brief compilation of the Nrf2 enrollment in the pathophysiology of the most common age-related diseases and bring insights for future research on the Nrf2 pathway is described. This review shows a controversial response of this transcriptional factor on the presented diseases. This reinforces the necessity of more studies to investigate modulation strategies for Nrf2, making it a possible therapeutic target in the treatment of age-related disorders.

Role of actin depolymerizing factor cofilin in Aspergillus fumigatus oxidative stress response and pathogenesis

2017 ◽  
Vol 64 (3) ◽  
pp. 619-634 ◽  
Author(s):  
Xiaodong Jia ◽  
Xi Zhang ◽  
Yingsong Hu ◽  
Mandong Hu ◽  
Shuguang Tian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Aspergillus Fumigatus ◽  
Oxidative Stress Response ◽  
Actin Depolymerizing Factor

The role of Yap1p and Skn7p-mediated oxidative stress response in the defence ofSaccharomyces cerevisiae against singlet oxygen

Yeast ◽  
2006 ◽  
Vol 23 (10) ◽  
pp. 741-750 ◽  
Author(s):  
Katrin Brombacher ◽  
Beat B. Fischer ◽  
Karin Rüfenacht ◽  
Rik I. L. Eggen
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
Singlet Oxygen ◽  
Oxidative Stress Response
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