Anti-resorptive therapy for osteoporosis and reduced mortality risk in elderly women and men: From the Dubbo Osteoporosis Epidemiology Study

Bone ◽  
2011 ◽  
Vol 48 ◽  
pp. S75
Author(s):  
J.A. Eisman⁎ ◽  
D. Bliuc ◽  
N.D. Nguyen ◽  
T.V. Nguyen ◽  
J.R. Center
Keyword(s):  
Mortality Risk ◽  
Elderly Women ◽  
Epidemiology Study ◽  
Osteoporosis Epidemiology

Contribution of fat mass and obesity-associated (FTO) gene to bone loss: The Dubbo osteoporosis epidemiology study

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S116
Author(s):  
B.N.H. Tran ◽  
N.D. Nguyen ◽  
J.R. Center ◽  
J.A. Eisman ◽  
T.V. Nguyen
Keyword(s):  
Bone Loss ◽  
Fat Mass ◽  
Epidemiology Study ◽  
Fto Gene ◽  
Osteoporosis Epidemiology

scholarly journals Erratum to: Association between fat mass, lean mass, and bone loss: the Dubbo osteoporosis epidemiology study

2015 ◽  
Vol 26 (6) ◽  
pp. 1865-1866 ◽  
Author(s):  
S. Yang ◽  
J. R. Center ◽  
J. A. Eisman ◽  
T. V. Nguyen
Keyword(s):  
Bone Loss ◽  
Fat Mass ◽  
Lean Mass ◽  
Epidemiology Study ◽  
Osteoporosis Epidemiology

Association between beta-blocker use and fracture risk: The Dubbo Osteoporosis Epidemiology Study

Bone ◽  
2011 ◽  
Vol 48 (3) ◽  
pp. 451-455 ◽  
Author(s):  
Shuman Yang ◽  
Nguyen D. Nguyen ◽  
Jacqueline R. Center ◽  
John A. Eisman ◽  
Tuan V. Nguyen
Keyword(s):  
Fracture Risk ◽  
Beta Blocker ◽  
Epidemiology Study ◽  
Osteoporosis Epidemiology

Symptomatic fracture incidence in elderly men and women: The Dubbo osteoporosis epidemiology study (DOES)

1994 ◽  
Vol 4 (5) ◽  
pp. 277-282 ◽  
Author(s):  
G. Jones ◽  
T. Nguyen ◽  
P. N. Sambrook ◽  
P. J. Kelly ◽  
C. Gilbert ◽  
...  
Keyword(s):  
Fracture Incidence ◽  
Epidemiology Study ◽  
Elderly Men ◽  
Men And Women ◽  
Osteoporosis Epidemiology

scholarly journals Secular Changes in Postfracture Outcomes Over 2 Decades in Australia: A Time-Trend Comparison of Excess Postfracture Mortality in Two Birth Controls Over Two Decades

2016 ◽  
Vol 101 (6) ◽  
pp. 2475-2483 ◽  
Author(s):  
Dana Bliuc ◽  
Thach Tran ◽  
Dunia Alarkawi ◽  
Tuan V. Nguyen ◽  
John A. Eisman ◽  
...  
Keyword(s):  
General Population ◽  
Life Expectancy ◽  
Community Dwelling ◽  
Fracture Incidence ◽  
Epidemiology Study ◽  
Birth Cohorts ◽  
Mineral Density ◽  
Initial Fracture ◽  
Population Mortality ◽  
Osteoporosis Epidemiology

Abstract Context: Hip fracture incidence has been declining and life expectancy improving. However, trends of postfracture outcomes are unknown. Objectives: The objective of the study was to compare the refracture risk and excess mortality after osteoporotic fracture between two birth cohorts, over 2 decades. Design: Prospective birth cohorts were followed up over 2 decades (1989–2004 and 2000–2014). Setting: The study was conducted in community-dwelling participants in Dubbo, Australia. Participants: Women and men aged 60–80 years, participating in Dubbo Osteoporosis Epidemiology Study 1 (DOES 1; born before 1930) and Dubbo Osteoporosis Epidemiology Study 2 (DOES 2; born after 1930) participated in the study. Main Outcome Measure: Age-standardized fracture and mortality over two time intervals: (1989–2004 [DOES 1] and 2000–2014 [DOES 2]) were measured. Results: The DOES 2 cohort had higher body mass index and bone mineral density and lower initial fracture rate than DOES 1, but similar refracture rates [age-standardized refracture rates per 1000 person-years: women: 53 (95% confidence interval [CI] 42–63) and 51 (95% CI 41–60) and men: 53 (95% CI 38–69) and 55 (95% CI 40–71) for DOES 2 and DOES 1, respectively). Absolute postfracture mortality rates declined in DOES 2 compared with DOES 1, mirroring the improvement in general-population life expectancy. However, when compared with period-specific general-population mortality, there was a similar 2.1- to 2.6-fold increased mortality risk after a fracture in both cohorts (age-adjusted standardized mortality ratio, women: 2.05 [95% CI 1.43–2.83] and 2.43 [95% CI 1.95–2.99] and men: 2.56 [95% CI 1.78–3.58] and 2.48 [95% CI 1.87–3.22] for DOES 2 and DOES 1, respectively). Conclusion: Over the 2 decades, despite the decline in the prevalence of fracture risk factors, general-population mortality, and initial fracture incidence, there was no improvement in postfracture outcomes. Refracture rates were similar and fracture-associated mortality was 2-fold higher than expected. These data indicate that the low postfracture treatment rates are still a major problem.

scholarly journals Progressive loss of bone in the femoral neck in elderly people: longitudinal findings from the Dubbo osteoporosis epidemiology study

BMJ ◽  
1994 ◽  
Vol 309 (6956) ◽  
pp. 691-695 ◽  
Author(s):  
G Jones ◽  
T Nguyen ◽  
P Sambrook ◽  
P J Kelly ◽  
J A Eisman
Keyword(s):  
Femoral Neck ◽  
Elderly People ◽  
Epidemiology Study ◽  
Progressive Loss ◽  
Osteoporosis Epidemiology
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