Reduced bone formation in alcohol-induced osteopenia is associated with elevated p21 expression in bone marrow cells in aldehyde dehydrogenase 2-disrupted mice

Bone ◽  
2011 ◽  
Vol 48 (5) ◽  
pp. 1075-1086 ◽  
Author(s):  
Yuki Shimizu ◽  
Akinori Sakai ◽  
Kunitaka Menuki ◽  
Toshiharu Mori ◽  
Toyohi Isse ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Aldehyde Dehydrogenase ◽  
Bone Marrow Cells ◽  
Aldehyde Dehydrogenase 2 ◽  
Marrow Cells

Osteoclastogenesis from bone marrow cells during estrogen-induced medullary bone formation in Japanese quails

2019 ◽  
Vol 50 (4) ◽  
pp. 389-404 ◽  
Author(s):  
Shinji Hiyama ◽  
Miyuki Yokoi ◽  
Yuichi Akagi ◽  
Yumiko Kadoyama ◽  
Kiichi Nakamori ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Bone Marrow Cells ◽  
Medullary Bone ◽  
Japanese Quails ◽  
Marrow Cells

STIMULATION OF BONE MARROW CELLS AND BONE FORMATION BY NACRE. IN VIVO AND IN VITRO STUDIES

Bioceramics ◽  
1999 ◽  
Author(s):  
M. Lamghari ◽  
S. Berland ◽  
A. Laurent ◽  
H. Huet ◽  
M.J. Almeida ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Bone Marrow Cells ◽  
In Vitro Studies ◽  
Stimulation Of ◽  
Marrow Cells

The Efficiency of FK 506 in In Vitro Bone Formation by Human Bone Marrow Cells

2003 ◽  
Vol 240-242 ◽  
pp. 659-662
Author(s):  
Noriko Okumura ◽  
Takafumi Yoshikawa ◽  
Jin Iida ◽  
Kunio Ichijima ◽  
Yoshinori Takakura
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Bone Marrow Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Fk 506 ◽  
Marrow Cells

scholarly journals Estrogen responsiveness of bone formation in vitro and altered bone phenotype in aged estrogen receptor-α-deficient male and female mice

2005 ◽  
Vol 152 (2) ◽  
pp. 301-314 ◽  
Author(s):  
Vilhelmiina Parikka ◽  
ZhiQi Peng ◽  
Teuvo Hentunen ◽  
Juha Risteli ◽  
Teresa Elo ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Bone Marrow Cells ◽  
Type I ◽  
Wild Type ◽  
Male And Female ◽  
Female Mice ◽  
Bone Phenotype ◽  
Marrow Cells

Objective: Although the beneficial effects of estrogen on bone are well known, the roles of estrogen receptors (ERs) in mediating these effects are not fully understood. Methods: To study the effects of long-term ERα deficiency, bone phenotype was studied in aged ERα knockout (ERKO) mice. In addition, ERKO osteoclasts and osteoblasts were cultured in vitro. Design and results: Histomorphometric analysis showed that the trabecular bone volume and thickness were significantly increased and the rate of bone formation enhanced in both male and female ERKO mice in comparison to the wild-type animals. In ERKO males, however, the bones were thinner and their maximal bending strengths decreased. Consistent with previous reports, the bones of knockout mice, especially of female mice, were shorter than those of wild-type mice. In addition, the growth plates were totally absent in the tibiae of aged ERKO females, whereas the growth plate cartilages were detectable in wild-type females as well as in all the males. Analysis of cultured bone marrow cells from 10- to 12-week-old mice demonstrated that 17β-estradiol could stimulate osteoblastic differentiation of bone marrow cells derived from ERKO mice relatively to the same extent as those derived from wild-type mice. This was demonstrated by increases in synthesis of type I collagen, activity of alkaline phosphatase and accumulation of calcium in cultures. Total protein content was, however, reduced in ERKO osteoblast cultures. Conclusions: These results show altered bone phenotype in ERKO mice and demonstrate the stimulatory effect of estrogen on osteoblasts even in the absence of full-length ERα.

Bone formation by rat bone marrow cells cultured on titanium fiber mesh: Effect ofin vitro culture time

2002 ◽  
Vol 62 (3) ◽  
pp. 350-358 ◽  
Author(s):  
Juliette van den Dolder ◽  
Johan W. M. Vehof ◽  
Paul H. M. Spauwen ◽  
John A. Jansen
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Bone Marrow Cells ◽  
Culture Time ◽  
Fiber Mesh ◽  
Cells Cultured ◽  
Rat Bone ◽  
Marrow Cells
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