The novel and selective insulin-like growth factor-1 receptor kinase inhibitor PQIP suppresses bone cell function and osteoclast-breast cancer cell cross-talk in vitro

Bone ◽  
2011 ◽  
Vol 48 (1) ◽  
pp. S43
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J.G. Logan* ◽  
E. Landao-Bassonga ◽  
V.G. Brunton ◽  
A.I. Idris
Diabetologia ◽  
2012 ◽  
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V. D’Esposito ◽  
F. Passaretti ◽  
A. Hammarstedt ◽  
D. Liguoro ◽  
D. Terracciano ◽  
...  

2010 ◽  
Vol 27 ◽  
pp. 1
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P. Ecimovic ◽  
B. McHugh ◽  
D. Murray ◽  
P. Doran ◽  
D. Buggy

2009 ◽  
Vol 103 (5) ◽  
pp. 685-690 ◽  
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C.A. Deegan ◽  
D. Murray ◽  
P. Doran ◽  
P. Ecimovic ◽  
D.C. Moriarty ◽  
...  

2011 ◽  
Vol 107 (6) ◽  
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J. McDonald ◽  
D.G. Lambert ◽  
...  

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Vol 31 ◽  
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P. Crowley ◽  
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D. J. Buggy

2017 ◽  
Vol 63 (1) ◽  
pp. 141-145
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Yuliya Khochenkova ◽  
Eliso Solomko ◽  
Oksana Ryabaya ◽  
Yevgeniya Stepanova ◽  
Dmitriy Khochenkov

The discovery for effective combinations of anticancer drugs for treatment for breast cancer is the actual problem in the experimental chemotherapy. In this paper we conducted a study of antitumor effect of the combination of sunitinib and bortezomib against MDA-MB-231 and SKBR-3 breast cancer cell lines in vitro. We found that bortezomib in non-toxic concentrations can potentiate the antitumor activity of sunitinib. MDA-MB-231 cell line has showed great sensitivity to the combination of bortezomib and sunitinib in vitro. Bortezomib and sunitinib caused reduced expression of receptor tyrosine kinases VEGFR1, VEGFR2, PDGFRa, PDGFRß and c-Kit on HER2- and HER2+ breast cancer cell lines


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