Human mesenchymal stem cell-differentiated osteoblast derived from bone marrow increases its immunogenicity by upregulating the expressions of co-stimulatory molecules

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S454 ◽  
Author(s):  
Qin Shi ◽  
Yanzheng Gu ◽  
Yan Cai ◽  
Li Ni ◽  
Chen Huang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Human Mesenchymal Stem Cell

scholarly journals The Bone Marrow-Derived Human Mesenchymal Stem Cell: Potential Progenitor of the Endometrial Stromal Fibroblast1

2010 ◽  
Vol 82 (6) ◽  
pp. 1076-1087 ◽  
Author(s):  
Lusine Aghajanova ◽  
Jose A. Horcajadas ◽  
Francisco J. Esteban ◽  
Linda C. Giudice
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Human Mesenchymal Stem Cell ◽  
Cell Potential ◽  
Stem Cell Potential

scholarly journals A Small Molecule Modulator of Prion Protein Increases Human Mesenchymal Stem Cell Lifespan, Ex Vivo Expansion, and Engraftment to Bone Marrow in NOD/SCID Mice

Stem Cells ◽  
2012 ◽  
Vol 30 (6) ◽  
pp. 1134-1143 ◽  
Author(s):  
Sindhu T. Mohanty ◽  
Claire J. Cairney ◽  
Andrew D. Chantry ◽  
Sanjeev Madan ◽  
James A. Fernandes ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Prion Protein ◽  
Small Molecule ◽  
Ex Vivo ◽  
Human Mesenchymal Stem Cell ◽  
Ex Vivo Expansion ◽  
Small Molecule Modulator ◽  
Cell Lifespan

In vivo study of the angiogenesis potential of bone marrow-derived mesenchymal stem cell aggregates in their niche like environment

2021 ◽  
pp. 039139882110255
Author(s):  
Sara Anajafi ◽  
Azam Ranjbar ◽  
Monireh Torabi-Rahvar ◽  
Naser Ahmadbeigi
Keyword(s):  
Tissue Engineering ◽  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cultured Cells ◽  
Morphological Evidence ◽  
Cell Aggregates ◽  
Plla Scaffold ◽  
Significant Difference

Background: Sufficient blood vessel formation in bioengineered tissues is essential in order to keep the viability of the organs. Impaired development of blood vasculatures results in failure of the implanted tissue. The cellular source which is seeded in the scaffold is one of the crucial factors involved in tissue engineering methods. Materials and methods: Considering the notable competence of Bone Marrow derived Mesenchymal Stem Cell aggregates for tissue engineering purposes, in this study BM-aggregates and expanded BM-MSCs were applied without any inductive agent or co-cultured cells, in order to investigate their own angiogenesis potency in vivo. BM-aggregates and BM-MSC were seeded in Poly-L Lactic acid (PLLA) scaffold and implanted in the peritoneal cavity of mice. Result: Immunohistochemistry results indicated that there was a significant difference ( p < 0.050) in CD31+ cells between PLLA scaffolds contained cultured BM-MSC; PLLA scaffolds contained BM-aggregates and empty PLLA. According to morphological evidence, obvious connections with recipient vasculature and acceptable integration with surroundings were established in MSC and aggregate-seeded scaffolds. Conclusion: Our findings revealed cultured BM-MSC and BM-aggregates, capacity in order to develop numerous connections between PLLA scaffold and recipient’s vasculature which is crucial to the survival of tissues, and considerable tendency to develop constructs containing CD31+ endothelial cells which can contribute in vessel’s tube formation.

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