Effect of body mass, body mass index (BMI) on bone formation and effect of body mass index on bone turnover and bone mass in postmenopausal women

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S448
Author(s):  
Qun Cheng ◽  
Huilin Li ◽  
Jiemin Gan ◽  
Xiaoying Zhu ◽  
Han-min Zhu
Keyword(s):  
Body Mass Index ◽  
Bone Formation ◽  
Bone Mass ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Body Mass

Interaction between body mass index and bone turnover during aromatase inhibition: Evidence from the letrozole (L), exemestane (E), and anastrozole (A) pharmacodynamics (LEAP) trial

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 560-560 ◽  
Author(s):  
E. McCloskey ◽  
R. Hannon ◽  
G. Lakner ◽  
G. Clack ◽  
A. Miyamoto ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Mass Index ◽  
Bone Resorption ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Early Breast Cancer ◽  
Aromatase Inhibitors ◽  
Baseline Bmi ◽  
High Bmi

560 Background: High body mass index (BMI) protects against postmenopausal osteoporotic fracture, mediated in part by higher endogenous levels of oestradiol. Third-generation aromatase inhibitors (AIs) show superior efficacy and tolerability than tamoxifen in the adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer. We examined the interactions between BMI and bone turnover during treatment with 3 aromatase inhibitors in the LEAP trial, an open, randomized, pharmacodynamic study in postmenopausal women. Methods: Healthy volunteers from the UK and Hungary with normal bone density and BMI between 18 and 34 kg/m2 were randomized to receive A (1 mg/day), L (2.5 mg/day), or E (25 mg/day) orally, once daily for 24 weeks. Effects on bone resorption (log transformed serum C-telopeptide crosslinks, CTX) and bone formation (bone alkaline phosphatase and propeptide of type I procollagen, PINP) were compared. Changes in biochemical markers of bone resorption and formation during treatment were all statistically inter- correlated (p<0.01) with no notable differences between the 3 agents studied, so that the groups were pooled for analysis. Spearman correlation coefficients and the p-values were computed. Results: A total of 90 participants were evaluable at baseline and at 24 weeks (29 A, 29 L, 32 E). As expected, baseline BMI correlated with pre-treatment circulating endogenous oestradiol (r=0.28, p=0.007) and both BMI and oestradiol negatively correlated with baseline serum CTX (r=-0.32, p=0.0025 and r=-0.35, p=0.0007 respectively) and PINP (r=-0.30, p=0.004 and r=-0.26, p=0.016 respectively). Baseline BMI and oestradiol were significantly correlated with the increase in serum CTX (r=0.26, p=0.015 and r=0.23, p=0.032 respectively) and BMI also correlated significantly with the increase in serum PINP (r=0.23, p=0.030). Conclusions: Steroidal and non-steroidal AIs increase bone turnover with the greatest increase in women with high BMI and higher oestradiol levels at baseline. As increased bone turnover is an independent risk factor for fracture, a high BMI may not confer a reduced fracture risk in the setting of AI use in early breast cancer. No significant financial relationships to disclose.

scholarly journals Gastric Bypass Surgery for Morbid Obesity Leads to an Increase in Bone Turnover and a Decrease in Bone Mass

2004 ◽  
Vol 89 (3) ◽  
pp. 1061-1065 ◽  
Author(s):  
Penelope S. Coates ◽  
John D. Fernstrom ◽  
Madelyn H. Fernstrom ◽  
Philip R. Schauer ◽  
Susan L. Greenspan
Keyword(s):  
Body Mass Index ◽  
Morbid Obesity ◽  
Gastric Bypass ◽  
Bone Mass ◽  
Bone Turnover ◽  
Body Mass ◽  
Bone Mineral ◽  
Collagen Type ◽  
Collagen Type 1

Abstract Little is known about the effects on the skeleton of laparoscopic Roux-en-Y gastric bypass (LRGB) surgery for morbid obesity and subsequent weight loss. We compared 25 patients who had undergone LRGB 11 ± 3 months previously with 30 obese controls matched for age, gender, and menopausal status. Compared with obese controls, patients post LRGB had significantly lower weight (92 ± 16 vs. 133 ± 20 kg; P &lt; 0.001) and body mass index (31 ± 5 vs. 48 ± 7 kg/m2; P &lt; 0.001). Markers of bone turnover were significantly elevated in patients post LRGB compared with controls (urinary N-telopeptide cross-linked collagen type 1, 93 ± 38 vs. 24 ± 11 nmol bone collagen equivalents per mmol creatinine; and osteocalcin, 11.6 ± 3.4 vs. 7.6 ± 3.6 ng/ml; both P &lt; 0.001). Fifteen patients were studied prospectively for an average of 9 months after LRGB. They lost 37 ± 9 kg and had a 29 ± 8% fall in body mass index (both P &lt; 0.001). Urinary N-telopeptide cross-linked collagen type 1 increased by 174 ± 168% at 3 months (P &lt; 0.01) and 319 ± 187% at 9 months (P &lt; 0.01). Bone mineral density decreased significantly at the total hip (7.8 ± 4.8%; P &lt; 0.001), trochanter (9.3 ± 5.7%; P &lt; 0.001), and total body (1.6 ± 2.0%; P &lt; 0.05), with significant decreases in bone mineral content at these sites. In summary, within 3 to 9 months after LRGB, morbidly obese patients have an increase in bone resorption associated with a decrease in bone mass. Additional studies are needed to examine these findings over the longer term.

Body Mass Index, Age, Weight, and Psychosocial Status Effect on Bone Mineral Density in Postmenopausal Women on Hemodialysis

2020 ◽  
Author(s):  
Seyyed-Mohsen Hosseininejad ◽  
Mehrdad Aghaei ◽  
Hossein Mohebi ◽  
Gholamreza Roshandel ◽  
Sahab-Sadat Tabatabaei ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Bone Mass ◽  
Postmenopausal Women ◽  
Body Mass ◽  
Bone Mineral ◽  
Prevalence Ratio ◽  
Normal Weight ◽  
Obese Women ◽  
Mineral Density

Background: Decreased bone mass, often measured using bone mineral density (BMD) is frequently seen in patients with end-stage renal disease (ESRD) undergoing hemodialysis. It may cause serious bone health problems such as fractures. Several risk factors of low bone mass in the patients on hemodialysis have been proposed including age and body mass index (BMI). Our current study explored the relationship between BMI, age, sociodemographic status, and BMD among postmenopausal women on hemodialysis. Methods: This study enrolled postmenopausal women on hemodialysis whose bone densitometry was checked and assessed with the age, BMI, and social status. Statistical analysis was performed in SPSS software. Results: Sixty participants with a mean ± standard deviation (SD) of age of 57.00 ± 10.63 years were enrolled. After adjustment of sex and age, normal-weight women had 2 times the prevalence of low bone density compared to the obese women [prevalence ratio (PR) = 2, 95% confidence interval (CI): 1.4–2.8]. For osteoporosis, the PR was also twice higher for the women with normal BMI (PR = 2, 95% CI: 1.3-2.8) and 1.6 times higher for the overweight group than the women in the obese group (PR = 1.6, 95% CI: 1.3-2.4). Conclusion: Among the women on hemodialysis, obese women have lower prevalence of osteoporosis than normal-weight cases.

Body mass index (BMI) and parameters of bone formation and resorption in postmenopausal women

Maturitas ◽  
2004 ◽  
Vol 47 (3) ◽  
pp. 185-193 ◽  
Author(s):  
E.F. Papakitsou ◽  
A.N. Margioris ◽  
K.E. Dretakis ◽  
G. Trovas ◽  
U. Zoras ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Bone Formation ◽  
Postmenopausal Women ◽  
Body Mass

scholarly journals Elevated Peptide YY Levels in Adolescent Girls with Anorexia Nervosa

2006 ◽  
Vol 91 (3) ◽  
pp. 1027-1033 ◽  
Author(s):  
Madhusmita Misra ◽  
Karen K. Miller ◽  
Patrika Tsai ◽  
Katie Gallagher ◽  
Alvin Lin ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Anorexia Nervosa ◽  
Food Intake ◽  
Bone Formation ◽  
Bone Turnover ◽  
Body Mass ◽  
Fat Mass ◽  
Peptide Yy ◽  
Bone Turnover Marker ◽  
Y2 Receptor

Abstract Background: Peptide YY (PYY) is an intestinally derived anorexigen that acts via the Y2 receptor, and Y2 receptor deletion in rodents increases bone formation. Anorexia nervosa (AN) is associated with a deliberate reduction in food intake and low bone density, but endocrine modulators of food intake in AN are not known. In addition, known regulators of bone turnover, such as GH, cortisol, and estrogen, explain only a fraction of the variability in bone turnover marker levels. Hypotheses: We hypothesized that PYY may be elevated in AN compared with controls and may contribute to decreased food intake and bone formation. Methods: Fasting PYY was examined in 23 AN girls and 21 healthy adolescents 12–18 yr old. We also examined GH, cortisol, ghrelin, and leptin (overnight frequent sampling) and fasting IGF-I, estradiol, total T3, and bone markers. Macronutrient intake and resting energy expenditure (REE) were measured. Results: AN girls had higher PYY levels compared with controls (17.8 ± 10.2 vs. 4.8 ± 4.3 pg/ml; P &lt; 0.0001). Predictors of log PYY were nutritional markers, including body mass index (r = −0.62; P &lt; 0.0001), fat mass (r = −0.55; P = 0.0003), and REE (r = −0.51; P = 0.0006), and hormones, including GH (r = 0.38; P = 0.004) and T3 (r = −0.59; P = 0.0001). Body mass index, fat mass, REE, GH, and T3 explained 68% of the variability of log PYY. Log PYY predicted percentage of calories from fat (r = −0.56; P = 0.0002) and independently predicted osteocalcin (r = −0.45; P = 0.003), bone-specific alkaline phosphatase (r = −0.46; P = 0.003), N-telopeptide/creatinine (r = −0.55; P = 0.0003), and deoxypyridinoline/creatinine (r = −0.52; P = 0.001) on regression modeling. Conclusion: Elevated PYY may contribute to reduced intake and decreased bone turnover in AN.

scholarly journals Analysis of Body Composition in Individuals With High Bone Mass Reveals a Marked Increase in Fat Mass in Women But Not Men

2013 ◽  
Vol 98 (2) ◽  
pp. 818-828 ◽  
Author(s):  
Celia L. Gregson ◽  
Margaret A. Paggiosi ◽  
Nicola Crabtree ◽  
Sue A. Steel ◽  
Eugene McCloskey ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Composition ◽  
Bone Mass ◽  
Bone Turnover ◽  
Body Mass ◽  
Fat Mass ◽  
Lean Mass ◽  
High Bone Mass ◽  
High Bone ◽  
Dxa Scans

Abstract Context: High bone mass (HBM), detected in 0.2% of dual-energy x-ray absorptiometry (DXA) scans, is characterized by raised body mass index, the basis for which is unclear. Objective: To investigate why body mass index is elevated in individuals with HBM, we characterized body composition and examined whether differences could be explained by bone phenotypes, eg, bone mass and/or bone turnover. Design, Setting, and Participants: We conducted a case-control study of 153 cases with unexplained HBM recruited from 4 UK centers by screening 219 088 DXA scans. A total of 138 first-degree relatives (of whom 51 had HBM) and 39 spouses were also recruited. Unaffected individuals served as controls. Main Outcome Measures: We measured fat mass, by DXA, and bone turnover markers. Results: Among women, fat mass was inversely related to age in controls (P = .01), but not in HBM cases (P = .96) in whom mean fat mass was 8.9 [95% CI 4.7, 13.0] kg higher compared with controls (fully adjusted mean difference, P &lt; .001). Increased fat mass in male HBM cases was less marked (gender interaction P = .03). Compared with controls, lean mass was also increased in female HBM cases (by 3.3 [1.2, 5.4] kg; P &lt; .002); however, lean mass increases were less marked than fat mass increases, resulting in 4.5% lower percentage lean mass in HBM cases (P &lt; .001). Osteocalcin was also lower in female HBM cases compared with controls (by 2.8 [0.1, 5.5] μg/L; P = .04). Differences in fat mass were fully attenuated after hip bone mineral density (BMD) adjustment (P = .52) but unchanged after adjustment for bone turnover (P &lt; .001), whereas the greater hip BMD in female HBM cases was minimally attenuated by fat mass adjustment (P &lt; .001). Conclusions: HBM is characterized by a marked increase in fat mass in females, statistically explained by their greater BMD, but not by markers of bone turnover.

Reduced bone mass and increased bone turnover in postmenopausal women with epilepsy using antiepileptic drug monotherapy

2008 ◽  
Vol 68 (8) ◽  
pp. 759-766 ◽  
Author(s):  
Merete Alice Lyngstad‐Brechan ◽  
Erik Taubøll ◽  
Karl Otto Nakken ◽  
Leif Gjerstad ◽  
Kristin Godang ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Antiepileptic Drug ◽  
Postmenopausal Women
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