Three-dimensional culture of osteoblast seeded on titanium alloy scaffold with controlled internal structure fabricated using electron beam melting techniques in vitro

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S422
Author(s):  
Hongxun Sang ◽  
Guochen Li ◽  
Lin Wang ◽  
Xiang Li ◽  
Yong Fan ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Electron Beam ◽  
Internal Structure ◽  
Electron Beam Melting ◽  
Three Dimensional ◽  
Three Dimensional Culture

In vitro dermal and epidermal cellular response to titanium alloy implants fabricated with electron beam melting

2014 ◽  
Vol 36 (10) ◽  
pp. 1367-1372 ◽  
Author(s):  
Jessica Collins Springer ◽  
Ola L.A. Harrysson ◽  
Denis J. Marcellin-Little ◽  
Susan H. Bernacki
Keyword(s):  
Titanium Alloy ◽  
Electron Beam ◽  
Electron Beam Melting ◽  
Cellular Response

scholarly journals Producing Of High-strength Titanium Alloy Vt22 By Method Of Electron Beam Melting

2018 ◽  
Vol 2018 (3) ◽  
pp. 8-15
Author(s):  
S.V. Akhonin ◽  
◽  
V.A. Berezos ◽  
A.N. Pikulin ◽  
A.Yu. Severin ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Electron Beam ◽  
Electron Beam Melting ◽  
High Strength ◽  
Alloy Vt22 ◽  
Titanium Alloy Vt22

scholarly journals Electron beam melting in the fabrication of three-dimensional mesh titanium mandibular prosthesis scaffold

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Rongzeng Yan ◽  
Danmei Luo ◽  
Haitao Huang ◽  
Runxin Li ◽  
Niu Yu ◽  
...  
Keyword(s):  
Electron Beam ◽  
Electron Beam Melting ◽  
Three Dimensional

Osteoconductivity of bioactive Ti-6Al-4V implants with lattice-shaped interconnected large pores fabricated by electron beam melting

2020 ◽  
pp. 088532822096821
Author(s):  
Mikinobu Goto ◽  
Akihiko Matsumine ◽  
Seiji Yamaguchi ◽  
Hiroyuki Takahashi ◽  
Koji Akeda ◽  
...  
Keyword(s):  
Electron Beam ◽  
Metal Powder ◽  
Metal Surface ◽  
Electron Beam Melting ◽  
Fibrous Tissue ◽  
Apatite Formation ◽  
Implant Fixation ◽  
Push Out ◽  
Interconnected Pores

Additive manufacturing has facilitated the fabrication of orthopedic metal implants with interconnected pores. Recent reports have indicated that a pore size of 600 μm is beneficial for material-induced osteogenesis. However, the complete removal of the metal powder from such small pores of implants is extremely difficult especially in electron beam melting (EBM). We therefore developed a new type of Ti-6Al-4V implant with lattice-shaped interconnected pores measuring 880–1400 μm, which allowed for the easy removal of metal powder. This implant was fabricated by EBM and treated with NaOH, CaCl2, heat, and water (ACaHW treatment) to render the metal surface bioactivity. In the present study, the mechanical and chemical property of the implants and the biocompatibility were evaluated. The SEM and micro-CT images demonstrated the 3D interconnectivity of the porous structures. The average porosity of the porous titanium implant was 57.5%. The implant showed maximum compressive load of 78.9 MPa and Young's modulus of 3.57 GPa which matches that of human cortical bone. ACaHW treatment of the porous Ti-6Al-4V implants induced apatite formation in simulated body fluid in vitro. The ACaHW-treated porous implants harvested from rabbit femoral bone showed direct bonding of bone to the metal surface without interposition of fibrous tissue. The porous ACaHW-treated implant had a higher affinity to the bone than the untreated one. The mechanical strength of implant fixation assessed using the push-out test was significantly higher in the ACaHW-treated implant than in untreated one. FE-SEM analysis and EDX mapping after push-out test of solid implants showed a lot of bone tissue patches on the surface of the ACaHW-treated implant. These results suggest that the new ACaHW-treated Ti-6Al-4V implant with lattice-shaped interconnected pores is a superior alternative to conventional materials for medical application.

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