Influence of leptin and insulin-like growth factor-1 on the relationship between fat mass and bone mineral density in Chinese postmenopausal women

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S366
Author(s):  
Hong-yan Zhao ◽  
Jian-min Liu ◽  
Li-hao Sun ◽  
Yin Chen ◽  
Lian-zhen Zhang ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Growth Factor ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Fat Mass ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Chinese Postmenopausal Women ◽  
The Relationship

Lean Mass and Fat Mass as Mediators of the Relationship Between Physical Activity and Bone Mineral Density in Postmenopausal Women

2017 ◽  
Vol 26 (5) ◽  
pp. 461-466 ◽  
Author(s):  
Jing Xiang ◽  
Yongjie Chen ◽  
Yupeng Wang ◽  
Shaofei Su ◽  
Xinyu Wang ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Fat Mass ◽  
Lean Mass ◽  
Mineral Density ◽  
The Relationship

scholarly journals POS0519 BONE MINERAL DENSITY, LEAN AND FAT MASS IN POSTMENOPAUSAL WOMEN WITH RHEUMATOID ARTHRITIS

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 493.2-493
Author(s):  
N. Toroptsova ◽  
O. Dobrovolskaya ◽  
A. Feklistov ◽  
O. Nikitinskaya ◽  
A. Efremova ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Fat Mass ◽  
Multivariate Linear Regression Analysis ◽  
Mineral Density ◽  
Total Hip ◽  
The Relationship

Background:The relationship between lean mass (LM), fat mass (FM) and bone mineral density (BMD) remains controversial. Some population studies have emphasized the positive association between them, while others have found an inverse relationship. RA patients are characterized by a decrease in muscle mass and an increase in fat mass. Such changes in body composition may be associated with low BMD.Objectives:To study the relationship between BMD, LM and FM in postmenopausal women with RA.Methods:68 postmenopausal women with RA (median age 59 [54; 63] years) were included in the study. BMD and body composition were evaluated using two-energy X-ray absorptiometry. Correlation analysis between body composition parameters and BMD was performed with the Spearman method, correlation coefficients R for p<0.05 are presented.Results:The average L1-L4 BMD was 0,92±0,16 g/cm2, total hip BMD - 0,84±0,15 g/cm2 and femoral neck - 0,73±0,13 g/cm2. 33 (48.5%) women had osteopenia, and 17 (25.0%) - osteoporosis (OP). Low appendicular LM was found in 5 (7.4%) and low appendicular muscle index (appendicular LM/height2, AMI) – in 10 (14.7%) patients. Overfat was revealed in 47 (69.1%) women, but only 20 (29.4%) women had BMI corresponding to obesity. The positive correlations between BMD in L1-L4, total hip and femoral neck regions and body weight (R=0.46, R=0.56 and R=0.50, respectively), trunk fat (R=0.4, R=0.51 and R=0.37, respectively), total FM (R=0.27, R=0.43 and R=0.34, respectively), trunk LM (R=0.55, R=0.54 and R=0.51, respectively), total LM (R=0.51, R=0.50 and R=0.52, respectively), appendicular LM (R=0.31, R=0.29 and R=0.37, respectively) and AMI (R=0.26, R=0.33 and R=0.51, respectively) were found out. In the multivariate linear regression analysis total LM was associated with BMD of lumbar spine (β=0.638, p=0.001) and total hip (β=0.473, p=0.008), and AMI - with femoral neck BMD (β=0.360; p=0.014). We found that FM hadn’t a significant effect on BMD in any region.Conclusion:73.5% of patients with RA had a reduced BMD, and 14.7% women – low AMI. LM was positively associated with BMDs in different regions of interest, but FM had no effect on BMD. Further researches are needed to identify associations between body composition, inflammatory activity and bone health in patients with RA.Disclosure of Interests:None declared

Bone mineral density: correlation with body weight, height, bone age and insulin-like growth factor

1997 ◽  
Vol 73 (4) ◽  
Author(s):  
José Hugo L. Pessoa ◽  
Shlomo Lewin ◽  
Carlos A. Longui ◽  
Berenice B. Mendonça
Keyword(s):  
Bone Mineral Density ◽  
Body Weight ◽  
Growth Factor ◽  
Bone Mineral ◽  
Bone Age ◽  
Insulin Like Growth Factor ◽  
Mineral Density ◽  
Density Correlation
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