In-silico sequencing of the GPR177 bone mineral density (BMD) locus using data from the “1000 genomes” project

Bone ◽  
2010 ◽  
Vol 47 ◽  
pp. S70
Author(s):  
F. Rivadeneira⁎ ◽  
K. Estrada ◽  
R. Kraaij ◽  
A. Hofman ◽  
H.A. Pols ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
In Silico ◽  
Mineral Density ◽  
1000 Genomes Project ◽  
1000 Genomes ◽  
Using Data

scholarly journals Pharmacogenomic effects of β-blocker use on femoral neck bone mineral density

2021 ◽  
Author(s):  
Kathleen T Nevola ◽  
Archana Nagarajan ◽  
Alexandra C Hinton ◽  
Katerina Trajanoska ◽  
Melissa M Formosa ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Single Nucleotide Polymorphisms ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Nucleotide Polymorphisms ◽  
Rotterdam Study ◽  
Mineral Density ◽  
Single Nucleotide ◽  
Β Blocker ◽  
Using Data

Abstract Context Recent studies have shown that β-blocker (BB) users have a decreased risk of fracture and higher bone mineral density (BMD) compared to non-users, likely due to the suppression of adrenergic signaling in osteoblasts, leading to increased BMD. There is also variability in the effect size of BB use on BMD in humans, which may be due to pharmacogenomic effects. Objective To investigate potential single nucleotide polymorphisms (SNPs) associated with the effect of BB use on femoral neck BMD, we performed a cross-sectional analysis using clinical data, dual-energy X-ray absorptiometry, and genetic data from the Framingham Heart Study’s (FHS) Offspring Cohort. We then sought to validate our top four genetic findings using data from the Rotterdam Study, the BPROOF Study, the MOFS, and the Hertfordshire Cohort Study. Design We used sex-stratified linear mixed models to determine SNPs that had a significant interaction effect with BB use on femoral neck (FN) BMD across 11 gene regions. We also evaluated the association of our top single nucleotide polymorphisms (SNPs) from the FHS with microRNA (miRNA) expression in blood and identified potential miRNA-mediated mechanisms by which these SNPs may impact FN BMD. Results One polymorphism (rs11124190 in HDAC4) was validated in females using data from the Rotterdam Study, while another (rs12414657 in ADRB1) was validated in females using data from the MOFS. We performed an exploratory meta-analysis of all 5 studies for these polymorphisms, which further validated our findings. Conclusions This analysis provides a starting point for investigating the pharmacogenomic effects of BB use on BMD measures.

Relationship between serum calcium levels and bone mineral density in liver transplant receipients

2001 ◽  
Vol 120 (5) ◽  
pp. A564-A564
Author(s):  
K ISLAM ◽  
S CREECH ◽  
R SOKHI ◽  
R KONDAVEETI ◽  
A NADIR ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Liver Transplant ◽  
Bone Mineral ◽  
Serum Calcium ◽  
Mineral Density

130: Role of Calcium Intake on Bone Mineral Density in Rostate Cancer Patients Under Androgen Deprivation Therapy

2006 ◽  
Vol 175 (4S) ◽  
pp. 41-42
Author(s):  
Anna Orsola ◽  
Jacques Planas ◽  
Carlos Salvador ◽  
José M. Abascal ◽  
Enrique Trilla ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cancer Patients ◽  
Androgen Deprivation Therapy ◽  
Bone Mineral ◽  
Calcium Intake ◽  
Androgen Deprivation ◽  
Mineral Density ◽  
Rostate Cancer

Abstract #510 Mineral Metabolism and Bone Mineral Density in Patients with Neuroendocrine Tumors

2018 ◽  
Vol 24 ◽  
pp. 110-111
Author(s):  
Franco Grimaldi ◽  
Elda Kara ◽  
Fabio Vanin ◽  
Maria Carpentieri ◽  
Claudia Cipri ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Neuroendocrine Tumors ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Mineral Density
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