Osteonecrosis of jaw and pathological fracture in patients with bisphosphonates treatment

Bone ◽  
2010 ◽  
Vol 46 ◽  
pp. S82
Author(s):  
Vaclav Vyskocil ◽  
Luboš Hauer ◽  
Daniel Hrušák ◽  
Petr Mukensnabl
Keyword(s):  
Pathological Fracture ◽  
Osteonecrosis Of Jaw

scholarly journals Care and management of bisphosphonate-associated osteonecrosis of jaw in patient with pathological fracture of mandible: case study

2019 ◽  
Vol 3 (23) ◽  
pp. 34-36
Author(s):  
M. V. Kirpichnikov ◽  
V. V. Podolsky ◽  
E. N. Yarygina ◽  
A. S. Serbin ◽  
K. A. Aleshanov
Keyword(s):  
Pathological Fracture ◽  
Signs And Symptoms ◽  
Osteonecrosis Of Jaw ◽  
Intravenous Bisphosphonates

This is a case study of patient with bisphosphonate associated osteonecrosis of the mandible after an extraction of teeth 4.6 and 4.7 complicated with pathological fracture while receiving intravenous bisphosphonates is discussed. The patients presenting signs and symptoms are reviewed. Bisphosphonates induced osteonecrosis definition and are reviewed management.

(Impending) Pathological Fracture

Swiss Surgery ◽  
2002 ◽  
Vol 8 (2) ◽  
pp. 81-87 ◽  
Author(s):  
Sutter ◽  
Regazzoni
Keyword(s):  
Pathological Fracture ◽  
Chirurgische Behandlung ◽  
Pathologische Fraktur ◽  
Score System ◽  
Postoperative Radiotherapie ◽  
Pathologische Frakturen

Pathologische Frakturen werden, bedingt durch die Zunahme der Inzidenz von Karzinomen und die längeren überlebenszeiten, in Zukunft häufiger behandelt werden müssen. Das Skelett ist das dritthäufigste Ziel-Organ von Metastasen. Lungentumor-Metastasen scheinen zuzunehmen, das Mammakarzinom bleibt aber der häufigste Primärtumor. Am häufigsten sind Metastasen im Bereiche der Wirbelsäule lokalisiert, Frakturen treten jedoch meistens am Femur auf. Eine pathologische Fraktur sowie fast immer auch eine "drohende pathologische Fraktur" stellen eine absolute Operationsindikation dar. Eine genaue Definition der "drohenden Fraktur" fehlt zwar, doch ist heute allgemein akzeptiert, dass mindestens 50% der Knochenmasse zerstört sein müssen, damit die Metastase im konventionellen Röntgenbild sichtbar wird und somit von einer drohenden Fraktur gesprochen werden kann. Als Hilfe zur Abschätzung des Frakturrisikos hat sich das Score System nach Mirels bewährt. Anhand von 4 Parametern (Lokalisation, Grösse, Typ, Schmerzen) kann das Frakturrisiko abgeschätzt werden. Ziel der (meist operativen) Behandlung ist die Verbesserung der Lebensqualität über eine effiziente Schmerzlinderung, möglichst durch eine einzige Operation mit kurzer Hospitalisationszeit. Für die chirurgische Behandlung sollten im proximalen Abschnitt des Femurs Prothesen verwendet werden, bei subtrochantären und Schaftfrakturen vornehmlich intramedulläre Kraftträger. Eine postoperative Radiotherapie scheint die lokale Tumorprogression zu verhindern. Bei guter Langzeitprognose sollte der Tumor lokal aggressiv ausgeräumt werden.

scholarly journals First-ever intraosseous ancient schwannoma of the proximal ulna successfully treated using the cement technique

2021 ◽  
Vol 49 (2) ◽  
pp. 030006052098773
Author(s):  
Kai Xuan Lim ◽  
Karl Wu
Keyword(s):  
Rare Case ◽  
Pathological Fracture ◽  
Soft Tissue Neoplasm ◽  
Proximal Ulna ◽  
Intraosseous Schwannoma ◽  
First Case ◽  
Primary Bone ◽  
Primary Bone Tumours ◽  
Current Report ◽  
Neural Sheath

Schwannoma or neurilemmoma is a common soft tissue neoplasm arising from the neural sheath of Schwann cells. However, intraosseous schwannoma is rare, accounting for less than 0.2% of primary bone tumours. Several variants of schwannoma have been reported; among them, intraosseous schwannoma with ancient change is extremely rare. This current report presents an extremely rare case of ancient intraosseous neurilemmoma. The patient presented with right elbow pain and disability. A radiolucent, well-defined, lobulated lesion with a thin sclerotic rim in the proximal ulnar metaphysis that had caused a pathological fracture was noted. The mass was surgically excised using marginal resection and bone curettage was undertaken. The bone deficit was grafted with hydroxyapatite and β-tricalcium phosphate and augmented with bone cement. There were no signs of any recurrence after 3 years. This is the first case of an ancient intraosseous schwannoma of the proximal ulna. Although rare, intraosseous schwannoma should be considered in the differential diagnosis of radiographically benign-appearing osseous tumours in the bone. The cement technique is recommended for the treatment of intraosseous schwannoma.

Pathological fracture of the proximal femur as first manifestation of malignancy of parotid gland

2011 ◽  
Vol 22 (3) ◽  
pp. 288-291
Author(s):  
Kamal Bali ◽  
Vishal Kumar ◽  
Uttam Saini ◽  
Shreekant Bharti
Keyword(s):  
Parotid Gland ◽  
Proximal Femur ◽  
Pathological Fracture

scholarly journals Factors Affecting the Recurrence of Giant Cell Tumor of Bone After Surgery: A Clinicopathological Study of 80 Cases from a Single Center

2015 ◽  
Vol 36 (5) ◽  
pp. 1961-1970 ◽  
Author(s):  
Dong-dong Cheng ◽  
Tu Hu ◽  
Hui-zhen Zhang ◽  
Jin Huang ◽  
Qing-cheng Yang
Keyword(s):  
Giant Cell Tumor ◽  
Pathological Fracture ◽  
Cell Tumor ◽  
Migration And Invasion ◽  
Ki 67 ◽  
Factors Affecting ◽  
Surgical Method ◽  
Kaplan Meier ◽  
Cd147 Expression

Background/Aims: This aim of the present study was to identify specific markers determining the recurrence of the giant cell tumor of bone (GCTB). Methods: This study involved the clinicopathological analysis of 80 cases. All of the clinical features, pathological fracture, Campanacci grade, histological features and surgical methods were reviewed. Immunohistochemistry was used to detect the expression of Ki-67, CD147, mutant p53 and p63 in GCTB. Comparisons between different groups were performed using the Chi-square test. The risk factors affecting recurrence were analyzed using a binary logistic model. Kaplan-Meier analysis was employed for the survival analysis between the groups. Cell proliferation assays, migration and invasion assays were used to detect the function of CD147 on GCTB in vitro. Results: The univariate analysis showed that Ki-67 and CD147 expression, pathological fracture, Campanacci grade and surgical method were associated with recurrence. The multivariate analysis revealed that CD147 expression, Campanacci grade and surgical method were the factors affecting GCTB recurrence. In addition, the Kaplan-Meier analysis revealed that these factors affected tumor-free survival time. In vitro study revealed that the CD147 knockdown by small interfering RNA (siRNA) technique dramatically reduced the proliferation, migration and invasion of GCTB. Conclusion: Our results suggest that CD147 may serve as an adequate marker for GCTB recurrence. Campanacci grade is a risk factor for GCTB recurrence, which is also affected by the surgical method used.

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