Lean Body Mass, Not Total Body Size, is a Stronger Determinant of Total Body Bone Mass in Boys

Bone ◽  
2010 ◽  
Vol 46 ◽  
pp. S80
Author(s):  
Tom Sanchez ◽  
Jingmei Wang ◽  
Chad Dudzek ◽  
George Ekker ◽  
Kathy Dudzek
1981 ◽  
Vol 33 (1) ◽  
pp. 361-363 ◽  
Author(s):  
B. Mazess ◽  
Walter W. Peppler ◽  
Charles H. Chesnut ◽  
Wil B. Nelp ◽  
Stanton H. Cohn ◽  
...  

1981 ◽  
Vol 33 (1) ◽  
pp. 365-368 ◽  
Author(s):  
R. B. Mazess ◽  
W. W. Peppler ◽  
J. E. Harrison ◽  
K. G. McNeill

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Julia Clarke ◽  
Hugo Peyre ◽  
Marianne Alison ◽  
Anne Bargiacchi ◽  
Coline Stordeur ◽  
...  

Abstract Background Early-onset anorexia nervosa (EO-AN) represents a significant clinical burden to paediatric and mental health services. The impact of EO-AN on bone mineral abnormalities has not been thoroughly investigated due to inadequate control for pubertal status. In this study, we investigated bone mineral abnormalities in girls with EO-AN regardless of pubertal development stage. Method We conducted a cross-sectional study of 67 girls with EO-AN (median age = 12.4 [10.9–13.7 years]) after a median duration of disease of 1.3 [0.6–2.0] years, and 67 healthy age-, sex-, pubertal status- matched control subjects. We compared relevant bone mineral parameters between groups: the total body bone mineral density [TB-BMD], the lumbar spine BMD [LS-BMD], the total body bone mineral content [TB-BMC] and the ratio of the TB-BMC to lean body mass [TB-BMC/LBM]. Results TB-BMD, TB-BMC, LS-BMD and TB-BMC/LBM were all significantly lower in patients with AN compared to controls. In the EO-AN group, older age, later pubertal stages and higher lean body mass were associated with higher TB-BMC, TB-BMD, and LS-BMD values. Discussion Girls with EO-AN displayed deficits in bone mineral content and density after adjustment for pubertal maturation. Age, higher pubertal stage and lean body mass were identified as determinants of bone maturation in the clinical population of patients with EO-AN. Bone health should be promoted in patients, specifically in those with an onset of disorder before 14 years old and with a delayed puberty.


2008 ◽  
Vol 20 (1) ◽  
pp. 40-49 ◽  
Author(s):  
Rômulo Maia Carlos Fonseca ◽  
Nanci Maria de França ◽  
Emmanuel Van Praagh

The purpose of the current study was to investigate the relationship between health-related physical fitness and bone mineral density (BMD) in adolescents. One hundred forty-four adolescents (65 boys and 79 girls) between 15 and 18 years of age were recruited to this cross-sectional study. Subjects were evaluated in aerobic fitness, muscular fitness, flexibility, body composition, and maturation. BMD of the lumbar spine, total body, and proximal femur were measured by a dual-energy X-ray absorptionmeter. Pearson’s correlation and stepwise multiple regression analyses were used (p < .05). Lean body mass (LBM) and abdominal muscular fitness explained 35–40% of proximal femur BMD in whole group and boys’ total body BMD (43%); however, VO2max and LBM predicted girls’ total body BMD (23%). Lumbar spine BMD was predicted only by LBM for both genders (18% boys, 15% girls). In summary, lean body mass is the main predictor of bone mass during the end of adolescence, regardless of gender, whereas muscular fitness contributes more to bone mass among males than among females.


1989 ◽  
Vol 256 (6) ◽  
pp. E829-E834 ◽  
Author(s):  
J. Wang ◽  
S. B. Heymsfield ◽  
M. Aulet ◽  
J. C. Thornton ◽  
R. N. Pierson

We measured fat in 286 healthy volunteers by underwater weighing (FUWW) and dual-photon absorptiometry (FDPA) to develop a translation table for the differing results from these entirely different techniques and to study the sources of these differences. In 99 males and 187 females aged 19-94 yr, fatness was 7-47%. Prediction equations are presented for FUWW-FDPA (delta F), density of lean body mass (DLBM), and FDPA. FUWW and FDPA were significantly different from each other (P less than 0.01). Calculated DLBM is less than the assumed constant of 1.10 (P less than 0.01), ranging widely from 1.05 to 1.13 and being highly correlated with the ratio of total body bone mineral to lean body mass (TBBM/LBM). delta F, the differences between FUWW and FDPA measurements in individual subjects, varied widely (-7 to +11% in males and -18 to +13% in females). The difference was positively correlated with the DLBM. FUWW was no better than anthropometrics in equations for predicting FDPA. The FDPA predicted from anthropometrics showed smaller standard errors than when FUWW was used. Neither anthropometrics nor FUWW equations are clearly superior to those previously available.


2002 ◽  
Vol 57 (3) ◽  
pp. 107-114 ◽  
Author(s):  
Pauline L. Martin ◽  
Joan Lane ◽  
Louise Pouliot ◽  
Malcolm Gains ◽  
Rudolph Stejskal ◽  
...  

1984 ◽  
Vol 17 (1) ◽  
pp. 63-65
Author(s):  
Akihiro Yamashita ◽  
Kazuhiro Ando ◽  
Katsuo Yoshimoto ◽  
Hideo Hidai ◽  
Kohji Shiraishi ◽  
...  

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
David A Guel ◽  
Matthias Peltz ◽  
Amit Khera ◽  
Donald D McIntire ◽  
Ronald M Peshock ◽  
...  

Introduction: Accurate description of normal aortic size is fundamental to our ability to define aortic aneurysms. However, current definitions of normal aortic dimensions are based on small population samples with limited data on other variables. This study used data from a large unselected community population to define normal aortic dimensions and to examine relationships between aortic size and demographic and anthropometric variables. Methods: Data came from a validated multiethnic urban population sample. Adults (age 18 – 65) underwent collection of demographic and medical history data. A subset of participants (n=2643) underwent gated aortic MRI to measure descending aortic diameter at the level of the pulmonary artery bifurcation. Age, gender, ethnicity (white, black, Hispanic or other) and multiple indices of body size and composition were collected or calculated from available data (body mass index [BMI], body surface area [BSA]). Dual-energy x-ray absorptiometry was used to calculate total body fat mass and lean body mass. A univariate analysis was performed relating descending aortic diameter to each variable. A stepwise variable selection using a p-value criteria of 0.15 for entry and removal was used to identify variables independently associated with aortic size. Results: By univariate analysis, increased aortic size was associated with increased age, male gender, black ethnicity, and greater height, weight, waist and hip circumference, BMI, BSA , total body fat mass and total body lean mass. By multivariable analysis, age, lean body mass, ethnicity, gender, waist circumference, and hip circumference emerged as significant determinants of descending aortic diameter (see Table). Conclusions: The diameter of the descending aorta appears to increase with age and is larger in certain ethnic groups and in subjects with greater indices of body size. Definitions of normal values for descending aortic dimensions may need to consider these factors.


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