Calcium absorption from calcium fortified soymilk and cow's milk in postmenopausal Chinese women with suboptimal serum 25-hydroxyvitamin D status

Bone ◽  
2008 ◽  
Vol 43 ◽  
pp. S31-S32
Author(s):  
Warren T.K. Lee ◽  
Ji Jiang ◽  
X.J. Lai ◽  
Pei Hu ◽  
H.Y. Wang
Epidemiology ◽  
2016 ◽  
Vol 27 (4) ◽  
pp. e29-e31 ◽  
Author(s):  
Grace J. Lee ◽  
Catherine S. Birken ◽  
Patricia C. Parkin ◽  
Gerald Lebovic ◽  
Yang Chen ◽  
...  

1986 ◽  
Vol 32 (5) ◽  
pp. 449-462 ◽  
Author(s):  
Toshio OKANO ◽  
Eizo KURODA ◽  
Hideto NAKAO ◽  
Soichi KODAMA ◽  
Tamotsu MATSUO ◽  
...  

2013 ◽  
Vol 17 (7) ◽  
pp. 1547-1554 ◽  
Author(s):  
Jessica A Omand ◽  
Pauline B Darling ◽  
Patricia C Parkin ◽  
Catherine S Birken ◽  
Marina Khovratovich ◽  
...  

AbstractObjectiveTo determine if children aged 1–6 years from non-Western immigrant families have lower serum 25-hydroxyvitamin D (25(OH)D) levels than children from Western-born families and examine which factors influence this relationship.DesignCross-sectional study.SettingToronto, Canada.SubjectsHealthy children (n1540) recruited through the TARGet Kids! practice-based research network. Serum 25(OH)D concentrations of non-Western immigrants were compared with those of children from Western-born families. Children from non-Western immigrant families were defined as those born, or their parents were born, outside a Western country. Univariate and multiple linear regression analyses were used to identify factors which might influence this relationship.ResultsMedian age was 36 months, 51 % were male, 86 % had ‘light’ skin pigmentation, 55 % took vitamin D supplements, mean cow's milk intake was 1·8 cups/d and 27 % were non-Western immigrants. Median serum 25(OH)D concentration was 83 nmol/l, with 5 % having 25(OH)D < 50 nmol/l. Univariable analysis revealed that non-Western immigrant children had serum 25(OH)D lower by 4 (95 % CI 1·3, 8·0) nmol/l (P= 0·006) and increased odds of 25(OH)D < 50 nmol/l (OR = 1·9; 95 % CI 1·3, 2·9). After adjustment for known vitamin D determinants the observed difference attenuated to 0·04 (95 % CI −4·8, 4·8) nmol/l (P= 0·99), with higher cow's milk intake (P< 0·0001), vitamin D supplementation (P< 0·0001), summer season (P= 0·008) and increased age (P= 0·04) being statistically significant covariates. Vitamin D supplementation was the strongest explanatory factor of the observed difference.ConclusionsThere is an association between non-Western immigration and lower 25(OH)D in early childhood. This difference appears related to known vitamin D determinants, primarily vitamin D supplementation, representing opportunities for intervention.


1977 ◽  
Vol 86 (4) ◽  
pp. 784-793 ◽  
Author(s):  
Gerd Offermann ◽  
Dieter Kraft

ABSTRACT Five patients with chronic post-operative hypoparathyroidism were treated with 450 μg/day 5,6-trans-25-hydroxyvitamin D3 (5,6-trans-25OHD3) for 14 days, and the treatment was continued with 150 μg/day for one year. At the end of this period the patients received 450 μg/day 5,6-cis-25-hydroxyvitamin D3 (5,6-cis-25OHD3) for 14 days. Comparison of the effects of both isomers revealed a similar ability to enhance intestinal calcium absorption and to normalize serum calcium; serum phosphate and alkaline phosphatase, however, remained unaffected. Urinary phosphate and hydroxyproline excretion decreased on the cis-isomer and increased on the trans-isomer. During treatment with the lower dose of 5,6-trans-25OHD3 intestinal calcium absorption remained in the normal range for one year, whereas the serum calcium decreased to the levels observed before administration of 450 μg/day within 6 weeks. The results suggest that in hypoparathyroidism 5,6-cis-25OHD3 and 5,6-trans-25OHD3 are equally effective on serum calcium and on intestinal calcium absorption, but that their mode of action on renal phosphate handling and on calcium release from bone is different.


2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 384-384
Author(s):  
Neuza Costa ◽  
Anamares Gomes ◽  
Caroline Silva ◽  
Keila Zanardi ◽  
Andre Costa

Abstract Objectives Kefir is a natural source of probiotics that confer benefits to the host's intestinal health. Yacon (Smallanthus sonchifolius) is a tuberous root originating in the Andes region, rich in prebiotic fructooligosaccharides (FOS), which increases the absorption of minerals. The objective of this study was to evaluate the prebiotic properties of yacon, the probiotic effect of kefir and the symbiotic action of the association between them in bone health in rats. Methods Adult Wistar rats were divided into 4 groups (n = 10): Group C (Control), Y (yacon flour, 51.34% FOS) K (kefir, 10⁷ UFC/mL), and YK (yacon flour + kefir). Group C received AIN-93 M + cow's milk (1 mL/day), group Y received AIN93 diet added by yacon flour to provide 5% FOS + cow's milk, group K received fermented kefir (1 mL/day), and group YK received yacon flour + fermented kefir. Feces and urine were collected for calcium balance in the last week of the experiment. At the end of 6 weeks, the animals were euthanized and the large intestine and blood sample were collected for analysis of intraluminal pH (pH meter Kasvi®) and biomarkers of bone remodeling, respectively. Calcium from diet, feces and urine was analyzed by atomic absorption. Osteocalcin (OC -- EL-R0243), C telopeptide of type I collagen (CTX – EL-R1456) and N telopeptide of type I collagen (NTX – EL-R0276) were analyzed by ELISA, according to manufacture's instructions (Elabscience, TX, USA). The results were analyzed by ANOVA, followed by the Tukey test (p &lt; 0.05), using GENES®. Results No significant differences were observed between groups concerning calcium balance and cecal pH, although pH was slightly lower in the groups fed yacon (Y and YK). Biomarkers of bone formation (OC) and bone resorption (CTX and NTX) were significantly lower in group K (OC = 7.29; CTX = 4.04; NTX = 94.31 ng/mL), compared to the control (OC = 16.33; CTX = 5.68; NTX = 105.97 ng/mL). Groups Y (OC = 13.63; CTX = 5.13; NTX = 114.34 ng/mL) and YK (OC = 15.37; CTX = 5.17; NTX = 132.51 ng/mL) did not differ from the control. Conclusions Prebiotic (Y) and Symbiotic (YK) were more effective than kefir in bone remodeling in rats, although fermentation in the large gut did not reduce pH sufficiently to improve calcium absorption and retention. Funding Sources FAPES; CNPq and CAPES/Brazil.


2011 ◽  
Vol 07 (02) ◽  
pp. 137 ◽  
Author(s):  
Robert P Heaney ◽  

The 2011 Institute of Medicine recommendations for vitamin D—both the recommended daily amount (RDA) and the vitamin D status judged adequate for bone health—are too low. Calcium absorption, osteoporotic fracture risk reduction, and healing of histological osteomalacia all require values above 30 ng/ml, and probably even 40 ng/ml. Furthermore, the proposed RDA (600 international units per day up to the age of 70) is not compatible with the blood level of 25-hydroxyvitamin D (i.e., 20 ng/ml) recommended in the same report. Concerns regarding adverse consequences of higher intakes or status levels can be dismissed, in view of our extensive experience with outdoor summer workers (who regularly have values of 60 ng/ml or more) and the virtual certainty that human physiology evolved in—and is attuned to—an environment providing 10,000 IU/day or more.


2015 ◽  
Vol 20 (10) ◽  
pp. 1746-1754 ◽  
Author(s):  
Chunfeng Yun ◽  
Jing Chen ◽  
Yuna He ◽  
Deqian Mao ◽  
Rui Wang ◽  
...  

AbstractObjectiveTo evaluate vitamin D deficiency prevalence and risk factors among pregnant Chinese women.DesignA descriptive cross-sectional analysis.SettingChina National Nutrition and Health Survey (CNNHS) 2010–2013.SubjectsA total of 1985 healthy pregnant women participated. Possible predictors of vitamin D deficiency were evaluated via multiple logistic regression analyses.ResultsThe median serum 25-hydroxyvitamin D level was 15·5 (interquartile range 11·9–20·0, range 3·0–51·5) ng/ml, with 74·9 (95 % CI 73·0, 76·7) % of participants being vitamin D deficient (25-hydroxyvitamin D <20 ng/ml). According to the multivariate logistic regression analyses, vitamin D deficiency was positively correlated with Hui ethnicity (P=0·016), lack of vitamin D supplement use (P=0·021) and low ambient UVB level (P<0·001). In the autumn months, vitamin D deficiency was related to Hui ethnicity (P=0·012) and low ambient UVB level (P<0·001). In the winter months, vitamin D deficiency was correlated with younger age (P=0·050), later gestational age (P=0·035), higher pre-pregnancy BMI (P=0·019), low ambient UVB level (P<0·001) and lack of vitamin D supplement use (P=0·007).ConclusionsVitamin D deficiency is prevalent among pregnant Chinese women. Residing in areas with low ambient UVB levels increases the risk of vitamin D deficiency, especially for women experiencing advanced stages of gestation, for younger pregnant women and for women of Hui ethnicity; therefore, vitamin D supplementation and sensible sun exposure should be encouraged, especially in the winter months. Further studies must determine optimal vitamin D intake and sun exposure levels for maintaining sufficient vitamin D levels in pregnant Chinese women.


2010 ◽  
Vol 105 (2) ◽  
pp. 282-286 ◽  
Author(s):  
Anne Lise Tang Fook Cheung ◽  
Gisela Wilcox ◽  
Karen Z. Walker ◽  
Nagendra P. Shah ◽  
Boyd Strauss ◽  
...  

Ageing women may choose to drink soya milk to reduce menopausal symptoms. As fermentation enriches soya milk with isoflavone aglycones, its beneficial qualities may improve. To reduce osteoporotic risk, however, soya milk must be Ca enriched, and it is not known how fermentation affects Ca bioavailability. A randomised crossover pilot study was undertaken to compare the Ca absorption of fortified soya milk with that of fermented and fortified soya milk in twelve Australian osteopenic post-menopausal women. The fortified soya milk was inoculated with Lactobacillus acidophilus American Type Culture Collection (ATCC) 4962 and fermented for 24 h at 37°C. Ca absorption from soya milk samples was measured using a single isotope radiocalcium method. Participants had a mean age of 54·8 (sd 12·3) years, with mean BMI of 26·5 (sd 5·5) kg/m2 and subnormal to normal serum 25-hydroxyvitamin D (mean 62·5 (sd 19·1) nmol/l). Participants consumed 185 kBq of 45Ca in 44 mg of Ca carrier. The mean fractional Ca absorption (α) from soya milk and fermented soya milk was 0·64 (sd 0·23) and 0·71 (sd 0·29), respectively, a difference not of statistical significance (P = 0·122). Although fermentation of soya milk may provide other health benefits, fermentation had little effect on acute Ca absorption.


Sign in / Sign up

Export Citation Format

Share Document