The abnormal phenotypes of cartilage and bone in calcium-sensing receptor deficient mice are dependent on the actions of calcium, phosphorus and parathyroid hormone

Bone ◽  
2008 ◽  
Vol 43 ◽  
pp. S31
Author(s):  
Jingning Liu ◽  
Chunxiang Tao ◽  
Wen Sun ◽  
Andrew Karaplis ◽  
David Goltzman ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Calcium Phosphorus ◽  
Deficient Mice

scholarly journals Hipocalcemia Crónica por Anticorpos Anti-Recetor do Cálcio

2014 ◽  
Vol 27 (3) ◽  
pp. 399
Author(s):  
Pedro Marques ◽  
Rita Santos ◽  
Branca Cavaco ◽  
Valeriano Leite
Keyword(s):  
Parathyroid Hormone ◽  
Genetic Disorder ◽  
Neck Surgery ◽  
Urinary Calcium ◽  
Clinical Report ◽  
Calcium Sensing Receptor ◽  
Casr Gene ◽  
Calcium Sensing ◽  
Calcium Phosphorus ◽  
Receptor Antibodies

<strong>Introduction:</strong> Hypoparathyroidism is an entity associated with hypocalcemia, more frequently a consequence of neck surgery. An autoimmune etiology is rare and its diagnosis difficult to establish.<br /><strong>Clinical report:</strong> 52 year-old woman, with irrelevant past medical history and no significant familial conditions, referred because of hypocalcemia and basal ganglia calcifications, detected in the course of investigation of myalgias. Besides hypocalcemia (4.6 mg/ dL), hyperphosphatemia (8.7 mg/dL), undetectable parathyroid hormone and low urinary calcium, phosphorus and magnesium were present. Molecular analysis of CaSR gene excluded germinal mutations. Anti-calcium sensing receptor antibodies (anti-CaSR) were present. The patient is asymptomatic and normocalcemic under treatment with calcium and vitamin D.<br /><strong>Discussion:</strong> Although rare, hypocalcemia due to anti-CaSR hypoparathyroidism must be considered in the absence of previous neck surgery, hypocalcemic drugs, familial history or phenotype suggesting a genetic disorder. Low or undetectable parathyroid hormone excludes pseudohypoparathyroidism and anti-CaSR positivity establishes the diagnosis.<br /><strong>Keywords:</strong> Hypocalcemia; Hypoparathyroidism; Autoantibodies; Receptors, Calcium-Sensing.

scholarly journals The Abnormal Phenotypes of Cartilage and Bone in Calcium-Sensing Receptor Deficient Mice Are Dependent on the Actions of Calcium, Phosphorus, and PTH

PLoS Genetics ◽  
2011 ◽  
Vol 7 (9) ◽  
pp. e1002294 ◽  
Author(s):  
Jingning Liu ◽  
Fangqiao Lv ◽  
Wen Sun ◽  
Chunxiang Tao ◽  
Guoxian Ding ◽  
...  
Keyword(s):  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Calcium Phosphorus ◽  
Deficient Mice

scholarly journals Relationship between parathyroid calcium-sensing receptor expression and potency of the calcimimetic, cinacalcet, in suppressing parathyroid hormone secretion in an in vivo murine model of primary hyperparathyroidism

2005 ◽  
Vol 153 (4) ◽  
pp. 587-594 ◽  
Author(s):  
Takehisa Kawata ◽  
Yasuo Imanishi ◽  
Keisuke Kobayashi ◽  
Takao Kenko ◽  
Michihito Wada ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Secondary Hyperparathyroidism ◽  
Murine Model ◽  
Hormone Secretion ◽  
Suppressive Effect ◽  
Receptor Expression ◽  
Parathyroid Glands ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing

Cinacalcet HCl, an allosteric modulator of the calcium-sensing receptor (CaR), has recently been approved for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis, due to its suppressive effect on parathyroid hormone (PTH) secretion. Although cinacalcet’s effects in patients with primary and secondary hyperparathyroidism have been reported, the crucial relationship between the effect of calcimimetics and CaR expression on the parathyroid glands requires better understanding. To investigate its suppressive effect on PTH secretion in primary hyperparathyroidism, in which hypercalcemia may already have stimulated considerable CaR activity, we investigated the effect of cinacalcet HCl on PTH-cyclin D1 transgenic mice (PC2 mice), a model of primary hyperparathyroidism with hypo-expression of CaR on their parathyroid glands. A single administration of 30 mg/kg body weight (BW) of cinacalcet HCl significantly suppressed serum calcium (Ca) levels 2 h after administration in 65- to 85-week-old PC2 mice with chronic biochemical hyperparathyroidism. The percentage reduction in serum PTH was significantly correlated with CaR hypo-expression in the parathyroid glands. In older PC2 mice (93–99 weeks old) with advanced hyperparathyroidism, serum Ca and PTH levels were not suppressed by 30 mg cinacalcet HCl/kg. However, serum Ca and PTH levels were significantly suppressed by 100 mg/kg of cinacalcet HCl, suggesting that higher doses of this compound could overcome severe hyperparathyroidism. To conclude, cinacalcet HCl demonstrated potency in a murine model of primary hyperparathyroidism in spite of any presumed endogenous CaR activation by hypercalcemia and hypo-expression of CaR in the parathyroid glands.

Association of Polymorphic Alleles of the Calcium-Sensing Receptor Gene with Parathyroid Hormone Secretion in Hemodialysis Patients

Nephron ◽  
2000 ◽  
Vol 85 (4) ◽  
pp. 317-323 ◽  
Author(s):  
Shozo Yano ◽  
Toshitsugu Sugimoto ◽  
Michiko Kanzawa ◽  
Tatsuo Tsukamoto ◽  
Tetsuya Hattori ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Receptor Gene ◽  
Hormone Secretion ◽  
Hemodialysis Patients ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Calcium Sensing Receptor Gene

Alterations in phosphorus, calcium and PTHrP appear to contribute to defects of dental formation in calcium-sensing receptor deficient mice

Bone ◽  
2008 ◽  
Vol 43 ◽  
pp. S49
Author(s):  
Wen Sun ◽  
Jingning Liu ◽  
Andrew Karaplis ◽  
David Goltzman ◽  
Dengshun Miao
Keyword(s):  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Deficient Mice

scholarly journals The calcium-sensing receptor regulates parathyroid hormone gene expression in transfected HEK293 cells

BMC Biology ◽  
2009 ◽  
Vol 7 (1) ◽  
pp. 17 ◽  
Author(s):  
Hillel Galitzer ◽  
Vardit Lavi-Moshayoff ◽  
Morris Nechama ◽  
Tomer Meir ◽  
Justin Silver ◽  
...  
Keyword(s):  
Gene Expression ◽  
Parathyroid Hormone ◽  
Hek293 Cells ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing
Sign in / Sign up

Export Citation Format

Share Document