Spatial distribution of anisotropic acoustic impedance assessed by time-resolved 50-MHz scanning acoustic microscopy and its relation to porosity in human cortical bone

Bone ◽  
2008 ◽  
Vol 43 (1) ◽  
pp. 187-194 ◽  
Author(s):  
A. Saïed ◽  
K. Raum ◽  
I. Leguerney ◽  
P. Laugier
Keyword(s):  
Spatial Distribution ◽  
Cortical Bone ◽  
Acoustic Impedance ◽  
Acoustic Microscopy ◽  
Scanning Acoustic Microscopy ◽  
Time Resolved ◽  
Human Cortical Bone

scholarly journals Use of Ultrasound Microscopy for Ex Vivo Analysis of Acoustic Impedance in Mouse Liver with Steatohepatitis

Acoustics ◽  
2020 ◽  
Vol 3 (1) ◽  
pp. 3-10
Author(s):  
Hideki Kumagai ◽  
Kazuto Kobayashi ◽  
Sachiko Yoshida ◽  
Koji Yokoyama ◽  
Norio Hirota ◽  
...  
Keyword(s):  
Acoustic Impedance ◽  
Ex Vivo ◽  
Acoustic Microscopy ◽  
Control Group ◽  
Scanning Acoustic Microscopy ◽  
Central Frequency ◽  
Deficient Diet ◽  
Acoustic Images ◽  
Ultrasound Microscopy

Scanning acoustic microscopy reveals information on histology and acoustic impedance through tissues. The objective of the present study was to investigate whether acoustic impedance values in the liver over time reflect the progression of steatohepatitis through different grades and stages, and whether this approach can visualize histologic features of the disease. Mice were divided into two groups: a control group and a steatohepatitis group prepared by keeping the mice on a methionine and choline-deficient diet for 56 weeks. The hepatic lobe was excised for measurement of impedance and observation of microscopic structure using a commercially available scanning acoustic microscopy system with a central frequency of 320 MHz. Scanning acoustic microscopy revealed that acoustic impedance through liver tissue with steatohepatitis temporarily decreased with the degree of fat deposition and then increased in parallel with the progression of inflammation and fibrosis. However, the acoustic images obtained did not allow discrimination of detailed microstructures from those seen using light microscopy. In conclusion, estimation of acoustic impedance appears to have potential clinical applications, such as for monitoring or follow-up studies.

Acoustic impedance measurement of tissue mimicking materials by using scanning acoustic microscopy

Ultrasonics ◽  
2021 ◽  
Vol 110 ◽  
pp. 106274 ◽  
Author(s):  
Burak Altun ◽  
Irem Demirkan ◽  
Esin Ozturk Isik ◽  
Ozgur Kocaturk ◽  
Mehmet Burcin Unlu ◽  
...  
Keyword(s):  
Acoustic Impedance ◽  
Impedance Measurement ◽  
Acoustic Microscopy ◽  
Scanning Acoustic Microscopy

The Application of Scanning Acoustic Microscopy in a Bone Remodeling Study

1995 ◽  
Vol 117 (3) ◽  
pp. 286-292 ◽  
Author(s):  
Sheu-Jane Shieh ◽  
M. C. Zimmerman ◽  
N. A. Langrana
Keyword(s):  
Bone Formation ◽  
Bone Remodeling ◽  
Acoustic Impedance ◽  
Basic Structure ◽  
Acoustic Microscopy ◽  
Scanning Acoustic Microscopy ◽  
New Bone Formation ◽  
Primary Mechanism ◽  
Low Modulus ◽  
Surface Remodeling

Scanning acoustic microscopy (SAM) was used in the evaluation of bone remodeling around a cylindrical unicortical defect. SAM is a technique for the nondestructive evaluation of materials, and has only recently been employed as an orthopaedic research tool. The utility of SAM was demonstrated by using it to measure an elastic property known as acoustic impedance. Specifically, the acoustic impedance of bone formed by remodeling around a cylindrical defect was measured. The defects were filled with either a low modulus “void” or rigid inclusion to create various states of stress in the bone in the vicinity of the defect. After six months of implantation of the inclusions in the sheep metatarsal, new bone formation on periosteal and endosteal surfaces about the defect region was observed. These regions of new bone were less stiff and had 18.0 ± 6.5% lower acoustic impedance than the pre-existing bone in the intracortical region of the metatarsal. There was no difference in the degree of new bone formation about void and rigid inclusions. Both underwent significant adaptational changes in response to the elevated stress about the defect. These changes affected the basic structure of the bone cross-section at the level of the defect and effectively reduced the stress levels about the defect. By using SAM to measure acoustic impedance, it was seen that little internal remodeling occurred in the intracortical region. Hence, the primary mechanism of strain-induced bone remodeling observed in this experimental model was surface remodeling.

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