WISE-2005: Supine treadmill exercise within lower body negative pressure and flywheel resistive exercise as a countermeasure to bed rest-induced bone loss in women during 60-day simulated microgravity

Bone ◽  
2008 ◽  
Vol 42 (3) ◽  
pp. 572-581 ◽  
Author(s):  
Scott M. Smith ◽  
Sara R. Zwart ◽  
Martina Heer ◽  
Stuart M.C. Lee ◽  
Natalie Baecker ◽  
...  
Keyword(s):  
Bone Loss ◽  
Negative Pressure ◽  
Simulated Microgravity ◽  
Treadmill Exercise ◽  
Lower Body Negative Pressure ◽  
Bed Rest ◽  
Lower Body ◽  
Resistive Exercise

scholarly journals Lower body negative pressure treadmill exercise as a countermeasure for bed rest-induced bone loss in female identical twins

Bone ◽  
2007 ◽  
Vol 40 (2) ◽  
pp. 529-537 ◽  
Author(s):  
Sara R. Zwart ◽  
Alan R. Hargens ◽  
Stuart M.C. Lee ◽  
Brandon R. Macias ◽  
Donald E. Watenpaugh ◽  
...  
Keyword(s):  
Bone Loss ◽  
Negative Pressure ◽  
Treadmill Exercise ◽  
Lower Body Negative Pressure ◽  
Bed Rest ◽  
Identical Twins ◽  
Lower Body

Supine Lower Body Negative Pressure Treadmill Exercise Maintains Upright Exercise Capacity In Women And Men After 30-d Bed Rest

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S36
Author(s):  
Stuart M.C. Lee ◽  
Suzanne M. Schneider ◽  
Donald E. Watenpaugh ◽  
Wanda L. Boda ◽  
Brandon R. Macias ◽  
...  
Keyword(s):  
Exercise Capacity ◽  
Negative Pressure ◽  
Treadmill Exercise ◽  
Lower Body Negative Pressure ◽  
Bed Rest ◽  
Lower Body

Lower body negative pressure exercise plus brief postexercise lower body negative pressure improve post-bed rest orthostatic tolerance

2007 ◽  
Vol 103 (6) ◽  
pp. 1964-1972 ◽  
Author(s):  
Donald E. Watenpaugh ◽  
Deborah D. O'Leary ◽  
Suzanne M. Schneider ◽  
Stuart M. C. Lee ◽  
Brandon R. Macias ◽  
...  
Keyword(s):  
Negative Pressure ◽  
Acute Exercise ◽  
Treadmill Exercise ◽  
Orthostatic Intolerance ◽  
Lower Body Negative Pressure ◽  
Bed Rest ◽  
Orthostatic Tolerance ◽  
Lower Body ◽  
Before And After ◽  
Head Up Tilt

Orthostatic intolerance follows actual weightlessness and weightlessness simulated by bed rest. Orthostasis immediately after acute exercise imposes greater cardiovascular stress than orthostasis without prior exercise. We hypothesized that 5 min/day of simulated orthostasis [supine lower body negative pressure (LBNP)] immediately following LBNP exercise maintains orthostatic tolerance during bed rest. Identical twins (14 women, 16 men) underwent 30 days of 6° head-down tilt bed rest. One of each pair was randomly selected as a control, and their sibling performed 40 min/day of treadmill exercise while supine in 53 mmHg (SD 4) [7.05 kPa (SD 0.50)] LBNP. LBNP continued for 5 min after exercise stopped. Head-up tilt at 60° plus graded LBNP assessed orthostatic tolerance before and after bed rest. Hemodynamic measurements accompanied these tests. Bed rest decreased orthostatic tolerance time to a greater extent in control [34% (SD 10)] than in countermeasure subjects [13% (SD 20); P < 0.004]. Controls exhibited cardiac stroke volume reduction and relative cardioacceleration typically seen after bed rest, yet no such changes occurred in the countermeasure group. These findings demonstrate that 40 min/day of supine LBNP treadmill exercise followed immediately by 5 min of resting LBNP attenuates, but does not fully prevent, the orthostatic intolerance associated with 30 days of bed rest. We speculate that longer postexercise LBNP may improve results. Together with our earlier related studies, these ground-based results support spaceflight evaluation of postexercise orthostatic stress as a time-efficient countermeasure against postflight orthostatic intolerance.

scholarly journals Treadmill exercise within lower body negative pressure protects leg lean tissue mass and extensor strength and endurance during bed rest

2016 ◽  
Vol 4 (15) ◽  
pp. e12892 ◽  
Author(s):  
Suzanne M. Schneider ◽  
Stuart M. C. Lee ◽  
Alan H. Feiveson ◽  
Donald E. Watenpaugh ◽  
Brandon R. Macias ◽  
...  
Keyword(s):  
Negative Pressure ◽  
Treadmill Exercise ◽  
Lower Body Negative Pressure ◽  
Bed Rest ◽  
Lower Body ◽  
Lean Tissue ◽  
Tissue Mass ◽  
Lean Tissue Mass

Supine Lower Body Negative Pressure Treadmill Exercise Maintains Upright Exercise Capacity In Women And Men After 30-d Bed Rest

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S36 ◽  
Author(s):  
Stuart M.C. Lee ◽  
Suzanne M. Schneider ◽  
Donald E. Watenpaugh ◽  
Wanda L. Boda ◽  
Brandon R. Macias ◽  
...  
Keyword(s):  
Exercise Capacity ◽  
Negative Pressure ◽  
Treadmill Exercise ◽  
Lower Body Negative Pressure ◽  
Bed Rest ◽  
Lower Body

Supine lower body negative pressure exercise during bed rest maintains upright exercise capacity

2000 ◽  
Vol 89 (1) ◽  
pp. 218-227 ◽  
Author(s):  
Donald E. Watenpaugh ◽  
Richard E. Ballard ◽  
Suzanne M. Schneider ◽  
Stuart M. C. Lee ◽  
Andrew C. Ertl ◽  
...  
Keyword(s):  
Negative Pressure ◽  
Treadmill Exercise ◽  
Lower Body Negative Pressure ◽  
Random Order ◽  
Bed Rest ◽  
Peak Oxygen Consumption ◽  
Time To Exhaustion ◽  
Lower Body ◽  
Sprint Speed ◽  
Earth Gravity

Bed rest and spaceflight reduce exercise fitness. Supine lower body negative pressure (LBNP) treadmill exercise provides integrated cardiovascular and musculoskeletal stimulation similar to that imposed by upright exercise in Earth gravity. We hypothesized that 40 min of supine exercise per day in a LBNP chamber at 1.0–1.2 body wt (58 ± 2 mmHg LBNP) maintains aerobic fitness and sprint speed during 15 days of 6° head-down bed rest (simulated microgravity). Seven male subjects underwent two such bed-rest studies in random order: one as a control study (no exercise) and one with daily supine LBNP treadmill exercise. After controlled bed-rest, time to exhaustion during an upright treadmill exercise test decreased 10%, peak oxygen consumption during the test decreased 14%, and sprint speed decreased 16% (all P < 0.05). Supine LBNP exercise during bed rest maintained all the above variables at pre-bed-rest levels. Our findings support further evaluation of LBNP exercise as a countermeasure against long-term microgravity-induced deconditioning.

Sign in / Sign up

Export Citation Format

Share Document