Low bone mineral density and high bone metabolism turnover in premenopausal women with unipolar depression

Bone ◽  
2008 ◽  
Vol 42 (3) ◽  
pp. 582-590 ◽  
Author(s):  
Milan Petronijević ◽  
Nataša Petronijević ◽  
Maja Ivković ◽  
Dušan Stefanović ◽  
Nevena Radonjić ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Premenopausal Women ◽  
Unipolar Depression ◽  
Mineral Density ◽  
Low Bone Mineral Density ◽  
High Bone

Management of bone metabolism in epilepsy

2021 ◽  
Vol 74 (7-8) ◽  
pp. 257-265
Author(s):  
Firdevs Ezgi Uçan Tokuç ◽  
Fatma Genç ◽  
Abidin Erdal ◽  
Yasemin Biçer Gömceli
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Outpatient Clinic ◽  
Bone Mineralization ◽  
Mineral Density ◽  
Low Bone Mineral Density ◽  
Increased Risk ◽  
Significant Difference

Many systemic problems arise due to the side effects of antiepileptic drugs (AEDs) used in epilepsy patients. Among these adverse effects are low bone mineral density and increased fracture risk due to long-term AED use. Although various studies have supported this association with increased risk in recent years, the length of this process has not been precisely defined and there is no clear consensus on bone density scanning, intervals of screening, and the subject of calcium and vitamin D supplementation. In this study, in accordance with the most current recommendations, our applications and data, including the detection of possible bone mineralization disorders, treatment methods, and recommendations to prevent bone mineralization disorders, were evaluated in epilepsy patients who were followed up at our outpatient clinic. It was aimed to draw attention to the significance of management of bone metabolism carried out with appropriate protocols. Epilepsy patients were followed up at the Antalya Training and Research Hospital Department of Neurology, Epilepsy Outpatient Clinic who were at high risk for osteoporosis (use of valproic acid [VPA] and enzyme-inducing drugs, using any AED for over 5 years, and postmenopausal women) and were evaluated using a screening protocol. According to this protocol, a total of 190 patients suspected of osteoporosis risk were retrospectively evaluated. Four patients were excluded from the study due to secondary osteoporosis. Of the 186 patients who were included in the study, 97 (52.2%) were women and 89 (47.8%) were men. Prevalence of low bone mineral density (BMD) was 42%, in which osteoporosis was detected in 11.8% and osteopenia in 30.6% of the patients. Osteoporosis rate was higher at the young age group (18-45) and this difference was statistically significant (p=0.018). There was no significant difference between male and female sexes according to osteoporosis and osteopenia rates. Patients receiving polytherapy had higher osteoporosis rate and lower BMD compared to patients receiving monotherapy. Comparison of separate drug groups according to osteoporosis rate revealed that osteoporosis rate was highest in patient groups using VPA+ carbamazepine (CBZ) (29.4%) and VPA polytherapy (19.4%). Total of osteopenia and osteoporosis, or low BMD, was highest in VPA polytherapy (VPA+ non-enzyme-inducing AED [NEID]) and CBZ polytherapy (CBZ+NEID) groups, with rates of 58.3% and 55.1%, respectively. In addition, there was no significant difference between drug groups according to bone metabolism markers, vitamin D levels, and osteopenia-osteoporosis rates. Assuming bone health will be affected at an early age in epilepsy patients, providing lifestyle and diet recommendations, avoiding polytherapy including VPA and CBZ when possible, and evaluating bone metabolism at regular intervals are actions that should be applied in routine practice.

Serum anti-Müllerian hormone levels are associated with low bone mineral density in premenopausal women

Biomarkers ◽  
2020 ◽  
Vol 25 (8) ◽  
pp. 693-700
Author(s):  
Yuzhu Yan ◽  
Wei Chen ◽  
Jihan Wang ◽  
Jing Huang ◽  
Jing Lv ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Premenopausal Women ◽  
Mineral Density ◽  
Hormone Levels ◽  
Low Bone Mineral Density

P292 Low bone mineral density in premenopausal women with major depression

2003 ◽  
Vol 14 ◽  
pp. S113-S114
Author(s):  
R. Leo ◽  
M. Tesauro ◽  
S. Rizza ◽  
E. Fortuna ◽  
F. Bianchi ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Major Depression ◽  
Bone Mineral ◽  
Premenopausal Women ◽  
Mineral Density ◽  
Low Bone Mineral Density

scholarly journals Bone Metabolism and Bone Mineral Density in Premenopausal Women with Mild Depression

2002 ◽  
Vol 43 (1) ◽  
pp. 101 ◽  
Author(s):  
Vural Kavuncu ◽  
Murat Kuloglu ◽  
Arzu Kaya ◽  
Sezai Sahin ◽  
Murad Atmaca ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Premenopausal Women ◽  
Mild Depression ◽  
Mineral Density
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