Cellular mechanisms for methotrexate chemotherapy-induced bone growth defects

Bone ◽  
2007 ◽  
Vol 41 (5) ◽  
pp. 842-850 ◽  
Author(s):  
Cory J. Xian ◽  
Johanna C. Cool ◽  
Michaela A. Scherer ◽  
Carmen E. Macsai ◽  
Chiaming Fan ◽  
...  
Keyword(s):  
Bone Growth ◽  
Cellular Mechanisms ◽  
Growth Defects ◽  
Methotrexate Chemotherapy

Mechanisms for methotrexate chemotherapy-induced bone growth defects and protective effects of folinic acid supplementary treatment

Bone ◽  
2007 ◽  
Vol 40 (6) ◽  
pp. S87-S88
Author(s):  
C.J. Xian ◽  
J. Cool ◽  
M. Scherer ◽  
C. Macsai ◽  
C. Fan ◽  
...  
Keyword(s):  
Folinic Acid ◽  
Bone Growth ◽  
Protective Effects ◽  
Growth Defects ◽  
Supplementary Treatment ◽  
Methotrexate Chemotherapy

scholarly journals Release of CXCL12 from Apoptotic Skeletal Cells Contributes to Bone Growth Defects Following Dexamethasone Therapy in Rats

2020 ◽  
Vol 35 (8) ◽  
pp. 1612-1613
Author(s):  
Qian Tang ◽  
Yu‐Wen Su ◽  
Chia‐Ming Fan ◽  
Rosa Chung ◽  
Mohammadhossein Hassanshahi ◽  
...  
Keyword(s):  
Bone Growth ◽  
Growth Defects ◽  
Dexamethasone Therapy

scholarly journals Release of CXCL12 From Apoptotic Skeletal Cells Contributes to Bone Growth Defects Following Dexamethasone Therapy in Rats

2018 ◽  
Vol 34 (2) ◽  
pp. 310-326 ◽  
Author(s):  
Qian Tang ◽  
Yu-Wen Su ◽  
Chia-Ming Fan ◽  
Rosa Chung ◽  
Mohammadhossein Hassanshahi ◽  
...  
Keyword(s):  
Bone Growth ◽  
Growth Defects ◽  
Dexamethasone Therapy

scholarly journals Molecular and Cellular Mechanisms of Melatonin in Osteosarcoma

Cells ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 1618 ◽  
Author(s):  
Ko-Hsiu Lu ◽  
Renn-Chia Lin ◽  
Jia-Sin Yang ◽  
Wei-En Yang ◽  
Russel J. Reiter ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Bone Growth ◽  
Age Distribution ◽  
Underlying Mechanism ◽  
Therapeutic Effects ◽  
Anticancer Activities ◽  
Cellular Mechanisms ◽  
Wide Range ◽  
Review Reports

Osteosarcoma, the most common primary bone malignancy, occurs most frequently in adolescents with a peak of incidence at 11–15 years. Melatonin, an indole amine hormone, shows a wide range of anticancer activities. The decrease in melatonin levels simultaneously concurs with the increase in bone growth and the peak age distribution of osteosarcoma during puberty, so melatonin has been utilized as an adjunct to chemotherapy to improve the quality of life and clinical outcomes. While a large amount of research has been conducted to understand the complex pleiotropic functions and the molecular and cellular actions elicited by melatonin in various types of cancers, a few review reports have focused on osteosarcoma. Herein, we summarized the anti-osteosarcoma effects of melatonin and its underlying molecular mechanisms to illustrate the known significance of melatonin in osteosarcoma and to address cellular signaling pathways of melatonin in vitro and in animal models. Even in the same kind of osteosarcoma, melatonin has been sparingly investigated to counteract tumor growth, apoptosis, and metastasis through different mechanisms, depending on different cell lines. We highlighted the underlying mechanism of anti-osteosarcoma properties evoked by melatonin, including antioxidant activity, anti-proliferation, induction of apoptosis, and the inhibition of invasion and metastasis. Moreover, we discussed the drug synergy effects of the role of melatonin involved and the method to fortify the anti-cancer effects on osteosarcoma. As a potential therapeutic agent, melatonin is safe for children and adolescents and is a promising candidate for an adjuvant by reinforcing the therapeutic effects and abolishing the unwanted consequences of chemotherapies.

Parathyroid Hormone in the Regulation of Bone Growth and Resorption in Health and Disease

2021 ◽  
Vol 76 (5) ◽  
pp. 506-517
Author(s):  
Maria V. Vorontsova ◽  
Konstantin Y. Kulebyakin ◽  
Nadezhda V. Makazan ◽  
Leila S. Sozaeva ◽  
Pyotr A. Tyurin-Kuzmin
Keyword(s):  
Parathyroid Hormone ◽  
Bone Tissue ◽  
Intracellular Signaling ◽  
Molecular Mechanisms ◽  
Bone Growth ◽  
The Body ◽  
Signaling Cascades ◽  
Main Body ◽  
Bone Homeostasis ◽  
Cellular Mechanisms

Parathyroid hormone (PTH) is a key hormone responsible for regulation of calcium homeostasis in the body. Since the main body calcium depot is bone tissue, PTH has a decisive effect on its homeostasis. In this case, the hormone can activate both bone formation and resorption. Thus, PTH can ensure the conjugation of anabolic and catabolic processes, which is necessary for the renewal of bone tissue, which is had to function under constant mechanical stress. At the same time, the use of PTH in medical practice is rather small, despite its high potential as a basis for the treatment of various pathologies associated with impaired bone homeostasis. Presented review, describes the intracellular signaling cascades and molecular mechanisms that underlie the action of PTH on bone tissue cells, and intracellular signaling cascades are described. A separate section examines the cellular mechanisms of the action of PTH on bone homeostasis, discusses how the effect of the hormone on different types of cells provides an interface between the processes of synthesis and resorption. In addition, the review examines diseases associated with impaired bone homeostasis, as well as the role of PTH and impaired signaling in their etiology.

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