Reply RE The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D

Bone ◽  
2007 ◽  
Vol 40 (6) ◽  
pp. 1670
Author(s):  
Karl Michaëlsson
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Dietary Vitamin ◽  
Repeat Polymorphism ◽  
Mineral Density ◽  
Vitamin D Intake ◽  
Dietary Vitamin D ◽  
Positive Effect

The positive effect of dietary vitamin D intake on bone mineral density in men is modulated by the polyadenosine repeat polymorphism of the vitamin D receptor

Bone ◽  
2006 ◽  
Vol 39 (6) ◽  
pp. 1343-1351 ◽  
Author(s):  
Karl Michaëlsson ◽  
Alicja Wolk ◽  
Annica Jacobsson ◽  
Andreas Kindmark ◽  
Elin Grundberg ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Vitamin D Receptor ◽  
Dietary Vitamin ◽  
Repeat Polymorphism ◽  
Mineral Density ◽  
Vitamin D Intake ◽  
Dietary Vitamin D ◽  
Positive Effect

Effects of vitamin D and estrogen receptor polymorphisms on bone mineral density in adolescents with anorexia nervosa

2019 ◽  
Vol 32 (12) ◽  
pp. 1377-1384
Author(s):  
Işıl İnan-Erdoğan ◽  
Sinem Akgül ◽  
Kübra Işgın-Atıcı ◽  
Tuğba Tuğrul-Yücel ◽  
Koray Boduroğlu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Estrogen Receptor ◽  
Anorexia Nervosa ◽  
Bone Mineral ◽  
Mineral Density ◽  
Vdr Gene ◽  
Positive Effects ◽  
Z Scores ◽  
Positive Effect

Abstract Background Anorexia nervosa (AN) is a serious eating disorder that is associated with decreased bone mineral density (BMD) and greater lifetime risk for fractures. The aim of this study was to determine the correlation between BMD and genetic polymorphisms in AN. Methods This case-control study analyzed vitamin D receptor (VDR) (VDRBsml, VDRFokl) and estrogen receptor (ESR) (ESR1Xbal, ESR1Pvull) polymorphisms in 45 adolescents diagnosed with AN and 46 age-matched healthy controls. BMD values of the AN group were classified as low or normal, and polymorphisms were compared between cases and controls. The effects of body mass index (BMI), duration of disease and amenorrhea on BMD were also evaluated. Results In girls with AN, a positive effect of the bb genotype of VDRBsmI polymorphism on femur Z-scores (p = 0.103) and of the Ff genotype of VDRFokI polymorphism on vertebra Z-scores (p = 0.097) was observed. In boys with AN, a positive effect of the Ff genotype of VDRFokI polymorphism on vertebra BMD (g/cm2) was detected (p = 0.061). No association was detected between ESR polymorphisms. An inverse relationship was observed between BMD and duration of illness and amenorrhea. A direct relationship was detected between BMD and BMI. Conclusions Specific VDR gene polymorphism genotypes may have positive effects on BMD in patients with AN. Additionally, the lack of association between ESR gene polymorphisms on BMD could be attributed to the low estrogen status of the patient.

scholarly journals Evaluating Bone Health in Egyptian Children with Forearm Fractures: A Case Control Study

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Abeer El-Sakka ◽  
Cristina Penon ◽  
Adham Hegazy ◽  
Salwa Elbatrawy ◽  
Amr Gobashy ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Case Control Study ◽  
Case Control ◽  
Forearm Fractures ◽  
Mineral Density ◽  
Vitamin D Intake ◽  
Egyptian Children ◽  
Control Study

Objective. To determine the likelihood of vitamin D deficiency and low bone mineral density in Egyptian children with forearm fractures.Methods. A case control study of 46 children aged 3 to 10 years with or without forearm fractures. Validated questionnaires were used to assess calcium and vitamin D intake as well as sun exposure. Serum calcium, phosphorus, alkaline phosphatase, and 25-hydroxy-vitamin D were collected. Bone mineral density was evaluated using dual-energy X-ray absorptiometry.Results. Compared to the Control group, calcium and vitamin D intake was lower in the Cases group (p=0.03). Cases had higher Body Mass Index than Controls,p=0.01. Children in the Cases group had lower mean serum calcium values8.3±1.4compared to9.3±1.1in Controls (p=0.01). Alkaline phosphatase was higher in Cases265±65.8than Controls226±54.6(p=0.03). Vitamin D and bone mineral density scores were significantly lower in the Cases group (p<0.05).Conclusion. Our data shows an increased rate of vitamin D deficiency and decreased bone mineral density in Egyptian children with forearm fractures.

scholarly journals Effects of school meals with weekly fish servings on vitamin D status in Danish children: secondary outcomes from the OPUS (Optimal well-being, development and health for Danish children through a healthy New Nordic Diet) School Meal Study

2015 ◽  
Vol 4 ◽  
Author(s):  
Rikke A. Petersen ◽  
Camilla T. Damsgaard ◽  
Stine-Mathilde Dalskov ◽  
Louise B. Sørensen ◽  
Mads Fiil Hjorth ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Mineral ◽  
Well Being ◽  
Dietary Vitamin ◽  
Secondary Outcome ◽  
School Meals ◽  
Mineral Density ◽  
School Meal ◽  
Vitamin D Intake ◽  
Meal Study

AbstractChildren's vitamin D intake and status can be optimised to meet recommendations. We investigated if nutritionally balanced school meals with weekly fish servings affected serum 25-hydroxyvitamin D (25(OH)D) and markers related to bone in 8- to 11-year-old Danish children. We conducted an explorative secondary outcome analysis on data from 784 children from the OPUS School Meal Study, a cluster-randomised cross-over trial where children received school meals for 3 months and habitual lunch for 3 months. At baseline, and at the end of each dietary period, 25(OH)D, parathyroid hormone (PTH), osteocalcin (OC), insulin-like growth factor-1 (IGF-1), bone mineral content (BMC), bone area (BA), bone mineral density (BMD), dietary intake and physical activity were assessed. School meals increased vitamin D intake by 0·9 (95 % CI 0·7, 1·1) μg/d. No consistent effects were found on 25(OH)D, BMC, BA, BMD, IGF-1 or OC. However, season-modified effects were observed with 25(OH)D, i.e. children completing the school meal period in January/February had higher 25(OH)D status (5·5 (95 % CI 1·8, 9·2) nmol/l; P = 0·004) than children completing the control period in these months. A similar tendency was indicated in November/December (4·1 (95 % CI –0·12, 8·3) nmol/l; P = 0·057). However, the effect was opposite in March/April (–4·0 (95 % CI –7·0, –0·9) nmol/l; P = 0·010), and no difference was found in May/June (P = 0·214). Unexpectedly, the school meals slightly increased PTH (0·18 (95 % CI 0·07, 0·29) pmol/l) compared with habitual lunch. Small increases in dietary vitamin D might hold potential to mitigate the winter nadir in Danish children's 25(OH)D status while higher increases appear necessary to affect status throughout the year. More trials on effects of vitamin D intake from natural foods are needed.

scholarly journals Positive association between the course of vitamin D intake and bone mineral density at 36 years in men

Bone ◽  
2009 ◽  
Vol 44 (3) ◽  
pp. 437-441 ◽  
Author(s):  
Christel Evelien van Dijk ◽  
Michiel Robert de Boer ◽  
Lando Lodewijk Joseph Koppes ◽  
Jan C. Roos ◽  
Paul Lips ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Mineral ◽  
Positive Association ◽  
Mineral Density ◽  
Vitamin D Intake

scholarly journals Effect of Low Dietary Vitamin D Fed Prior to and During Pregnancy and Lactation on Maternal Bone Mineral Density, Structure and Strength in C57BL/6 Mice

2021 ◽  
Author(s):  
Christopher R Villa ◽  
Sandra M Sacco ◽  
Jianmin Chen ◽  
Amel Taibi ◽  
Elena M Comelli ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Strength ◽  
Bone Mineral ◽  
Distal Femur ◽  
Bone Structure ◽  
Lumbar Vertebra ◽  
Dietary Vitamin ◽  
Mineral Density ◽  
Pregnancy And Lactation

ABSTRACT Several studies have shown that diets containing lower vitamin D than in the AIN-93G diet do not compromise bone structure, bone mineral density (BMD) and/or bone strength in male and female mice. This study determined if a diet containing low vitamin D from pre-pregnancy through the end of lactation maintained these bone outcomes to a similar extent as a high vitamin D diet. Mice were fed an AIN-93G diet with 25 (LD diet) or 5000 (HD diet) IU vitamin D/kg diet from pre-mating through lactation (n = 15/group). Of the major structure outcomes, only cortical area fraction of the distal femur was lower (P &lt; 0.05) with LD diet. Lumbar vertebra BMD was lower (P &lt; 0.05) with LD while distal femur BMD and bone strength at three sites did not differ. Dams fed a LD diet pre-mating through the end of lactation had largely similar bone outcomes to dams fed a HD diet.

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