Weight-bearing exercise and bone mineral accrual in children and adolescents: A review of controlled trials

Bone ◽  
2007 ◽  
Vol 40 (1) ◽  
pp. 14-27 ◽  
Author(s):  
K. Hind ◽  
M. Burrows
Keyword(s):  
Children And Adolescents ◽  
Bone Mineral ◽  
Weight Bearing ◽  
Controlled Trials ◽  
Bone Mineral Accrual

Re: ‘Weight-bearing exercise and bone mineral accrual in children and adolescents: A review of controlled trials' Bone 2007 40:14–27

Bone ◽  
2007 ◽  
Vol 41 (5) ◽  
pp. 903-905 ◽  
Author(s):  
Moira A. Petit ◽  
Julie M. Hughes ◽  
Rachel J. Wetzsteon ◽  
Susan A. Novotny ◽  
Meghan Warren
Keyword(s):  
Children And Adolescents ◽  
Bone Mineral ◽  
Weight Bearing ◽  
Controlled Trials ◽  
Bone Mineral Accrual

scholarly journals Inhibition of the Serotonin (5-Hydroxytryptamine) Transporter Reduces Bone Accrual during Growth

Endocrinology ◽  
2005 ◽  
Vol 146 (2) ◽  
pp. 685-693 ◽  
Author(s):  
Stuart J. Warden ◽  
Alexander G. Robling ◽  
Megan S. Sanders ◽  
Michael M. Bliziotes ◽  
Charles H. Turner
Keyword(s):  
Children And Adolescents ◽  
Bone Mineral ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Bone Growth ◽  
Bone Cells ◽  
Gene Encoding ◽  
Skeletal Phenotype ◽  
Null Mutant Mice ◽  
The Impact ◽  
Bone Mineral Accrual

Abstract Selective serotonin-reuptake inhibitors (SSRIs) antagonize the serotonin (5-hydroxytryptamine) transporter (5-HTT), and are frequently prescribed to children and adolescents to treat depression. However, recent findings of functional serotonergic pathways in bone cells and preliminary clinical evidence demonstrating detrimental effects of SSRIs on bone growth have raised questions regarding the effects of these drugs on the growing skeleton. The current work investigated the impact of 5-HTT inhibition on the skeleton in: 1) mice with a null mutation in the gene encoding for the 5-HTT; and 2) growing mice treated with a SSRI. In both models, 5-HTT inhibition had significant detrimental effects on bone mineral accrual. 5-HTT null mutant mice had a consistent skeletal phenotype of reduced mass, altered architecture, and inferior mechanical properties, whereas bone mineral accrual was impaired in growing mice treated with a SSRI. These phenotypes resulted from a reduction in bone formation without an increase in bone resorption and were not influenced by effects on skeletal mechanosensitivity or serum biochemistries. These findings indicate a role for the 5-HTT in the regulation of bone accrual in the growing skeleton and point to a need for further research into the prescription of SSRIs to children and adolescents.

scholarly journals Bone Mineral Accrual Is Associated With Parathyroid Hormone and 1,25-Dihydroxyvitamin D Levels in Children and Adolescents

2015 ◽  
Vol 100 (10) ◽  
pp. 3814-3821 ◽  
Author(s):  
Mark D. DeBoer ◽  
David R. Weber ◽  
Babette S. Zemel ◽  
Michelle R. Denburg ◽  
Rita Herskovitz ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Dihydroxyvitamin D ◽  
1,25 Dihydroxyvitamin D ◽  
Bone Mineral Accrual

Weight-bearing, muscle loading and bone mineral accrual in pubertal girls—A 2-year longitudinal study

Bone ◽  
2007 ◽  
Vol 40 (5) ◽  
pp. 1196-1202 ◽  
Author(s):  
Qingju Wang ◽  
Markku Alén ◽  
Patrick Nicholson ◽  
Harri Suominen ◽  
Arvo Koistinen ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Bone Mineral ◽  
Weight Bearing ◽  
Muscle Loading ◽  
Bone Mineral Accrual

scholarly journals Nutritional factors associated with femoral neck bone mineral density in children and adolescents

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Guo-Hau Gou ◽  
Feng-Jen Tseng ◽  
Sheng-Hao Wang ◽  
Pao-Ju Chen ◽  
Jia-Fwu Shyu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Femoral Neck ◽  
Children And Adolescents ◽  
Bone Mineral ◽  
Age Group ◽  
Mineral Density ◽  
Nutrient Intakes ◽  
Nutritional Factors ◽  
Daily Total

Abstract Background Nutritional factors including vitamin D, magnesium, and fat are known to affect bone mineral accrual. This study aimed to evaluate associations between dietary nutrient intakes (both macronutrients and micronutrients) and bone mineral density (BMD) in children and adolescents. Methods Data for this cross-sectional, population-based study were derived from the National Health and Nutrition Examination Survey (NHANES). Participants aged from 8 to 19 years were included. The primary outcome was femoral neck BMD. Results Multivariate analyses revealed that for participants aged 8 to 11, daily sodium intake was significantly and positively associated with femoral neck BMD (B = 0.9 ×  10− 5, p = 0.031); in particular, subgroup analyses by sex found that in male participants aged 8–11, daily total cholesterol intake (B = 5.3 × 10− 5, p = 0.030) and calcium intake (B = − 2.0 × 10− 5, p < 0.05) were significantly associated with femoral neck BMD in a positive and negative manner, respectively, but neither were observed in female participants of this age group. In contrast, daily intakes of vitamin D and magnesium were significantly and positively associated with femoral neck BMD in female participants aged 8–11 (B = 246.8 × 10− 5 and 16.3 × 10− 5, p = 0.017 and 0.033, respectively). For participants aged 16 to 19, daily total fat intake was significantly and negatively associated with femoral neck BMD (B = − 58 × 10− 5, p = 0.048); further stratification by sex found that magnesium and sodium intakes were significantly and positively associated with femoral neck BMD only in females of this age group (B = 26.9 × 10− 5 and 2.1 × 10− 5, respectively; both p < 0.05). However, no significant associations between daily nutrient intakes and femoral neck BMD were identified in participants aged 12–15 before or after subgroup stratification. Conclusion The study found that associations of specific nutrition-related variables with BMD of the femoral neck is dependent upon age and gender.

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