Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair

Bone ◽  
2006 ◽  
Vol 39 (4) ◽  
pp. 678-683 ◽  
Author(s):  
Mauro Krampera ◽  
Giovanni Pizzolo ◽  
Giuseppe Aprili ◽  
Massimo Franchini
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Muscle Repair

scholarly journals Trends in Mesenchymal Stem Cells' Applications for Skeletal Muscle Repair and Regeneration

10.5772/60919 ◽  
2015 ◽  
Author(s):  
A.R. Caseiro ◽  
T. Pereira ◽  
P.J. Bártolo ◽  
J.D. Santos ◽  
A.L. Luís ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Muscle Repair

scholarly journals Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane

2003 ◽  
Vol 160 (6) ◽  
pp. 909-918 ◽  
Author(s):  
Cosimo De Bari ◽  
Francesco Dell'Accio ◽  
Frank Vandenabeele ◽  
Joris R. Vermeesch ◽  
Jean-Marc Raymackers ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Nude Mouse ◽  
Synovial Membrane ◽  
Myogenic Differentiation ◽  
Muscle Repair ◽  
Mouse Muscle ◽  
Adult Human

We have demonstrated previously that adult human synovial membrane-derived mesenchymal stem cells (hSM-MSCs) have myogenic potential in vitro (De Bari, C., F. Dell'Accio, P. Tylzanowski, and F.P. Luyten. 2001. Arthritis Rheum. 44:1928–1942). In the present study, we have characterized their myogenic differentiation in a nude mouse model of skeletal muscle regeneration and provide proof of principle of their potential use for muscle repair in the mdx mouse model of Duchenne muscular dystrophy. When implanted into regenerating nude mouse muscle, hSM-MSCs contributed to myofibers and to long term persisting functional satellite cells. No nuclear fusion hybrids were observed between donor human cells and host mouse muscle cells. Myogenic differentiation proceeded through a molecular cascade resembling embryonic muscle development. Differentiation was sensitive to environmental cues, since hSM-MSCs injected into the bloodstream engrafted in several tissues, but acquired the muscle phenotype only within skeletal muscle. When administered into dystrophic muscles of immunosuppressed mdx mice, hSM-MSCs restored sarcolemmal expression of dystrophin, reduced central nucleation, and rescued the expression of mouse mechano growth factor.

scholarly journals Therapeutic potential of adipose-derived stem cells and macrophages for ischemic skeletal muscle repair

2017 ◽  
Vol 12 (2) ◽  
pp. 153-167 ◽  
Author(s):  
Viktoriya Rybalko ◽  
Pei-Ling Hsieh ◽  
Laura M Ricles ◽  
Eunna Chung ◽  
Roger P Farrar ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Therapeutic Potential ◽  
Adipose Derived Stem Cells ◽  
Muscle Repair

scholarly journals Coaxing stem cells for skeletal muscle repair

2015 ◽  
Vol 84 ◽  
pp. 198-207 ◽  
Author(s):  
Karl J.A. McCullagh ◽  
Rita C.R. Perlingeiro
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Muscle Repair

Immediate and delayed transplantation of mesenchymal stem cells improve muscle force after skeletal muscle injury in rats

2012 ◽  
Vol 6 (S3) ◽  
pp. s60-s67 ◽  
Author(s):  
Tobias Winkler ◽  
Philipp von Roth ◽  
Piotr Radojewski ◽  
Alexander Urbanski ◽  
Sebastian Hahn ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Muscle Injury ◽  
Muscle Force ◽  
Skeletal Muscle Injury

scholarly journals Skeletal Muscle-Derived Human Mesenchymal Stem Cells: Influence of Different Culture Conditions on Proliferative and Myogenic Capabilities

2020 ◽  
Vol 11 ◽  
Author(s):  
Stefano Testa ◽  
Carles Sánchez Riera ◽  
Ersilia Fornetti ◽  
Federica Riccio ◽  
Claudia Fuoco ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Culture Conditions

scholarly journals Insulin-Like Growth Factor Binding Protein-6 Promotes the Differentiation of Placental Mesenchymal Stem Cells into Skeletal Muscle Independent of Insulin-Like Growth Factor Receptor-1 and Insulin Receptor

2019 ◽  
Vol 2019 ◽  
pp. 1-18 ◽  
Author(s):  
Doaa Aboalola ◽  
Victor K. M. Han
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Muscle Differentiation ◽  
Insulin Like Growth Factor ◽  
Differentiation Process ◽  
Placental Mesenchymal Stem Cells

As mesenchymal stem cells (MSCs) are being investigated for regenerative therapies to be used in the clinic, delineating the roles of the IGF system in MSC growth and differentiation, in vitro, is vital in developing these cellular therapies to treat degenerative diseases. Muscle differentiation is a multistep process, starting with commitment to the muscle lineage and ending with the formation of multinucleated fibers. Insulin-like growth factor binding protein-6 (IGFBP-6), relative to other IGFBPs, has high affinity for IGF-2. However, the role of IGFBP-6 in muscle development has not been clearly defined. Our previous studies showed that in vitro extracellular IGFBP-6 increased myogenesis in early stages and could enhance the muscle differentiation process in the absence of IGF-2. In this study, we identified the signal transduction mechanisms of IGFBP-6 on muscle differentiation by placental mesenchymal stem cells (PMSCs). We showed that muscle differentiation required activation of both AKT and MAPK pathways. Interestingly, we demonstrated that IGFBP-6 could compensate for IGF-2 loss and help enhance the muscle differentiation process by triggering predominantly the MAPK pathway independent of activating either IGF-1R or the insulin receptor (IR). These findings indicate the complex interactions between IGFBP-6 and IGFs in PMSC differentiation into the skeletal muscle and that the IGF signaling axis, specifically involving IGFBP-6, is important in muscle differentiation. Moreover, although the major role of IGFBP-6 is IGF-2 inhibition, it is not necessarily the case that IGFBP-6 is the main modulator of IGF-2.

scholarly journals Anti-Fibrotic Effect of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells on Skeletal Muscle Cells, Mediated by Secretion of MMP-1

2020 ◽  
Vol 21 (17) ◽  
pp. 6269
Author(s):  
Alee Choi ◽  
Sang Eon Park ◽  
Jang Bin Jeong ◽  
Suk-joo Choi ◽  
Soo-young Oh ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Wharton’S Jelly ◽  
Mdx Mice ◽  
Therapeutic Effects ◽  
Paracrine Factors ◽  
Wharton's Jelly ◽  
Muscle Fibrosis ◽  
Skeletal Muscle Fibrosis

Extracellular matrix (ECM) components play an important role in maintaining skeletal muscle function, but excessive accumulation of ECM components interferes with skeletal muscle regeneration after injury, eventually inducing fibrosis. Increased oxidative stress level caused by dystrophin deficiency is a key factor in fibrosis in Duchenne muscular dystrophy (DMD) patients. Mesenchymal stem cells (MSCs) are considered a promising therapeutic agent for various diseases involving fibrosis. In particular, the paracrine factors secreted by MSCs play an important role in the therapeutic effects of MSCs. In this study, we investigated the effects of MSCs on skeletal muscle fibrosis. In 2–5-month-old mdx mice intravenously injected with 1 × 105 Wharton’s jelly (WJ)-derived MSCs (WJ-MSCs), fibrosis intensity and accumulation of calcium/necrotic fibers were significantly decreased. To elucidate the mechanism of this effect, we verified the effect of WJ-MSCs in a hydrogen peroxide-induced fibrosis myotubes model. In addition, we demonstrated that matrix metalloproteinase-1 (MMP-1), a paracrine factor, is critical for this anti-fibrotic effect of WJ-MSCs. These findings demonstrate that WJ-MSCs exert anti-fibrotic effects against skeletal muscle fibrosis, primarily via MMP-1, indicating a novel target for the treatment of muscle diseases, such as DMD.

T.P.6.04 Comparison of skeletal muscle potential of mesenchymal stem-cells from different sources injected in SJL mice

2009 ◽  
Vol 19 (8-9) ◽  
pp. 633-634
Author(s):  
E. Zucconi ◽  
N.M. Vieira ◽  
C.R. Bueno Junior ◽  
V. Brandalise ◽  
M. Secco ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Different Sources ◽  
Muscle Potential
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