Descriptive analysis of bisphosphonates use in patients with cancer and bone metastasis

Bone ◽  
2006 ◽  
Vol 38 (3) ◽  
pp. 78
Author(s):  
V. Launay-Vacher ◽  
S. Oudard ◽  
N. Janus ◽  
C. Le Tourneau ◽  
O. Rixe ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Descriptive Analysis ◽  
Patients With Cancer

scholarly journals Prescription Opioids Dispensed to Patients with Cancer with Bone Metastasis: 2011‐2017

2021 ◽  
Author(s):  
Hao Zhang ◽  
Judith Paice ◽  
Russell Portenoy ◽  
Eduardo Bruera ◽  
M Carrington Reid ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Prescription Opioids ◽  
Patients With Cancer

scholarly journals Physiopathology of Spine Metastasis

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Giulio Maccauro ◽  
Maria Silvia Spinelli ◽  
Sigismondo Mauro ◽  
Carlo Perisano ◽  
Calogero Graci ◽  
...  
Keyword(s):  
Growth Factors ◽  
Bone Metastasis ◽  
Lymphatic System ◽  
Spinal Metastasis ◽  
Bone Destruction ◽  
The Body ◽  
Vicious Cycle ◽  
Patients With Cancer ◽  
Local Tumour ◽  
Neurological Injuries

The metastasis is the spread of cancer from one part of the body to another. Two-thirds of patients with cancer will develop bone metastasis. Breast, prostate and lung cancer are responsible for more than 80% of cases of metastatic bone disease. The spine is the most common site of bone metastasis. A spinal metastasis may cause pain, instability and neurological injuries. The diffusion through Batson venous system is the principal process of spinal metastasis, but the dissemination is possible also through arterial and lymphatic system or by contiguity. Once cancer cells have invaded the bone, they produce growth factors that stimulate osteoblastic or osteolytic activity resulting in bone remodeling with release of other growth factors that lead to a vicious cycle of bone destruction and growth of local tumour.

scholarly journals A descriptive analysis of depression and pain complaints among patients with cancer in a low income country

PLoS ONE ◽  
2018 ◽  
Vol 13 (3) ◽  
pp. e0193713 ◽  
Author(s):  
Melkam Alemayehu ◽  
Negussie Deyessa ◽  
Girmay Medihin ◽  
Abebaw Fekadu
Keyword(s):  
Low Income ◽  
Descriptive Analysis ◽  
Income Country ◽  
Low Income Country ◽  
Patients With Cancer

scholarly journals Risk Evaluation of Denosumab And Zoledronic Acid For Medication-Related Osteonecrosis of The Jaw In Patients With Bone Metastases: A Propensity Score-Matched Analysis

2021 ◽  
Author(s):  
Hiroaki Ikesue ◽  
Kohei Doi ◽  
Mayu Morimoto ◽  
Masaki Hirabatake ◽  
Nobuyuki Muroi ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Bone Metastasis ◽  
Propensity Score ◽  
Proportional Hazards ◽  
Significant Risk ◽  
Patient Characteristics ◽  
Osteonecrosis Of The Jaw ◽  
Cox Proportional Hazards ◽  
Close Monitoring ◽  
Patients With Cancer

Abstract Purpose: This study evaluated the risk of medication-related osteonecrosis of the jaw (MRONJ) in patients with cancer who received denosumab or zoledronic acid (ZA) for treating bone metastasis.Methods: The medical records of patients were retrospectively reviewed. Patients who did not undergo a dental examination at baseline were excluded. The primary endpoint was a comparison of the risk of developing MRONJ between the denosumab and ZA groups. Propensity score matching was used to control for baseline differences between patient characteristics and compare outcomes for both groups.Results: Among the 799 patients enrolled, 58 (7.3%) developed MRONJ. The incidence of MRONJ was significantly higher in the denosumab group than in the ZA group (9.6% [39/406] vs. 4.8% [19/393], p = 0.009). Multivariate Cox proportional hazards regression analysis revealed that denosumab treatment (hazard ratio [HR], 2.89; 95% confidence interval [CI], 1.65–5.25; p < 0.001) and tooth extraction after starting ZA or denosumab (HR, 4.26; 95% CI, 2.38–7.44; p < 0.001) were significant risk factors for MRONJ. Propensity score-matched analysis confirmed that the risk of developing MRONJ was significantly higher in the denosumab group than in the ZA group (HR, 2.34; 95% CI, 1.17–5.01; p = 0.016). Conclusion: The results of this study suggest that denosumab poses a significant risk for developing MRONJ in patients treated for bone metastasis, and thus these patients require close monitoring.

scholarly journals Survival rates of patients with cancer of the lip, mouth and pharynx: a cohort study of 10 years

2014 ◽  
Vol 17 (3) ◽  
pp. 680-691 ◽  
Author(s):  
Ione Jayce Ceola Schneider ◽  
Mayara Eloisa Flores ◽  
Daniela Alba Nickel ◽  
Luiz Gustavo Teixeira Martins ◽  
Jefferson Traebert
Keyword(s):  
Cohort Study ◽  
Clinical Stage ◽  
Descriptive Analysis ◽  
Survival Rates ◽  
Incidence Rates ◽  
Advanced Clinical Stage ◽  
Death Risk ◽  
Patients With Cancer ◽  
Kaplan Meier ◽  
Using Data

Introduction: Cancer of the lip, mouth and pharynx is a serious health problem. High incidence rates are found worldwide. In Brazil, the Southern and Southeastern regions have the highest incidences in the country. Objective: To describe 5 and 10-year survival rates in patients with cancer of the lip, mouth and pharynx at a referral center in Florianopolis, Santa Catarina, Brazil. Methods: Retrospective cohort study using data from patients diagnosed between January 1st and December 31st, 2001, with follow-up until December 31st, 2011. Descriptive analysis was performed and survival was estimated by Kaplan-Meier method. Cox semi-parametric model was used to estimate death risk. Results: Survival rates at 5 and 10 years were 33.3 and 26.9%, respectively. Advanced clinical stage in the diagnosis increased death risk by 2.88 and 2.51, respectively. Sex, ethnicity, level of education, previous diagnosis and treatment, as well as age, did not show significant association. Conclusion: Survival rate at 5 years was 33.3% and, at 10 years, was 26.9%. Advanced stage was an independent risk factor for death due to cancer of the lip, mouth and pharynx in both periods analyzed.

scholarly journals Preventing Discontinuation of Radiation Therapy: Predictive Factors to Improve Patient Selection for Palliative Treatment

2017 ◽  
Vol 13 (9) ◽  
pp. e782-e791 ◽  
Author(s):  
Lindsay L. Puckett ◽  
Eric Luitweiler ◽  
Louis Potters ◽  
Sewit Teckie
Keyword(s):  
Overall Survival ◽  
Radiation Therapy ◽  
Bone Metastasis ◽  
Brain Metastases ◽  
Patient Selection ◽  
Karnofsky Performance Status ◽  
Performance Status ◽  
Factors Associated ◽  
Patients With Cancer ◽  
Selection For

Purpose: Approximately one third of patients with cancer require palliative radiation therapy (PRT), yet no guidelines exist for optimal patient selection. We have observed that many patients who begin PRT do not complete their prescribed treatment. Our study sought to identify factors associated with discontinuation of PRT, assess for a relationship with survival, and inform patient selection. Methods: We performed an institutional review board–approved retrospective analysis of patients with cancer treated in a multicenter radiation oncology department in 2014. Of 297 patients who began PRT, 60 discontinued and 237 completed treatment. Primary end points included discontinuation and overall survival. Results: Patient factors were analyzed for association with discontinuation of PRT and overall survival, respectively, using logistic regression and Cox proportional regression models. Factors associated with discontinuation were low Karnofsky performance status (KPS) score, high number of fractions prescribed, and treatment site other than bone metastasis. The odds of discontinuing PRT decreased by approximately 52% for every 10-point increase in KPS score (odds ratio, 0.48; 95% CI, 0.36 to 0.63; P < .001). Factors associated with shorter survival included discontinuation of PRT, low KPS score, community practice location, multiple comorbidities, and treatment of brain metastases. Patients who discontinued treatment were more likely to die than patients who completed treatment, independent of other factors (hazard ratio, 3.67; 95% CI, 2.41 to 5.61; P < .001). Conclusion: Patients with low KPS scores, long treatment courses, and those treated to sites other than bone metastasis were significantly more likely to discontinue treatment. Discontinuation was predictive for poor survival. Pretreatment evaluation of KPS, comorbidities, and brain metastases can help guide appropriate patient selection for PRT.

scholarly journals Multimodal Imaging-Based Potential Visualization of the Tumor Microenvironment in Bone Metastasis

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2877
Author(s):  
Jang Bae Moon ◽  
Su Woong Yoo ◽  
Changho Lee ◽  
Dong-Yeon Kim ◽  
Ayoung Pyo ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Tumor Microenvironment ◽  
Multimodal Imaging ◽  
Imaging Techniques ◽  
Management Plan ◽  
Imaging Modalities ◽  
Multiple Site ◽  
Factors Affecting ◽  
Patients With Cancer ◽  
Site Evaluation

Bone metastasis (BM) is the most common malignant bone tumor and a significant cause of morbidity and mortality for patients with cancer. Compared to other metastatic organs, bone has unique characteristics in terms of the tumor microenvironment (TME). Precise assessments of the TME in BM could be an important step for developing an optimized management plan for patient care. Imaging approaches for BM have several advantages, such as biopsy not being required, multiple site evaluation, and serial assessment in the same sites. Owing to the developments of new imaging tracers or imaging modalities, bone TME could be visualized using multimodal imaging techniques. In this review, we describe the BM pathophysiology, diagnostic principles of major imaging modalities, and clinically available imaging modalities to visualize the TME in BM. We also discuss how the interactions between various factors affecting the TME could be visualized using multimodal imaging techniques.

scholarly journals DESCRIPTIVE ANALYSIS OF PRIMARY BREAST TUMORS CHARACTERISTICS IN PATIENTS WITH BONE METASTASIS

2019 ◽  
Vol 2 (2) ◽  
Author(s):  
A. C. Tutovanu ◽  
Georgiana Radu ◽  
S. M. Oprescu
Keyword(s):  
Breast Cancer ◽  
Nervous System ◽  
Bone Metastasis ◽  
Initial Treatment ◽  
Severe Disease ◽  
Descriptive Analysis ◽  
Breast Tumors ◽  
High Morbidity ◽  
The World ◽  
Metastatic Development

Breast cancer is a severe disease with high morbidity and mortality affecting both women and men from all around the world. When it does not get diagnosed in early stages it metastasizes to other organs and tissues, thus becoming incurable. In addition, between 25-50% of patients will suffer from a metastatic development after the initial treatment. The most common locations are the bones, the liver, the lungs and the nervous system. The current research is an analysis of the molecular, macroscopic and microscopic characteristics of tumors in a cohort of 67 female patients with bone metastases from an initial breast neoplasm.

Wernicke encephalopathy without delirium in patients with cancer

2017 ◽  
Vol 16 (1) ◽  
pp. 118-121 ◽  
Author(s):  
Hideki Onishi ◽  
Mayumi Ishida ◽  
Iori Tanahashi ◽  
Takao Takahashi ◽  
Yoshitada Taji ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Gait Disturbance ◽  
Wernicke Encephalopathy ◽  
Appetite Loss ◽  
Laboratory Findings ◽  
Patients With Cancer ◽  
Non Hodgkin Lymphoma ◽  
Outpatient Visits ◽  
Unsteady Gait ◽  
Loss Of Appetite

ABSTRACTObjective:Wernicke encephalopathy (WE) is a neuropsychiatric disorder caused by thiamine deficiency. Several reports of WE in cancer patients are known. WE is sometimes overlooked because most patients do not exhibit its typical symptoms (e.g., delirium, ataxia, ocular palsy). If delirium is not present, a diagnosis of WE is difficult because delirium is the hallmark symptom of WE.Method:Taken from a series on WE in cancer, we report two patients who developed WE without delirium during periodic psycho-oncology outpatient visits.Results:Case 1. A 61-year-old woman with non-Hodgkin lymphoma who was periodically attending a psycho-oncology outpatient clinic developed an unsteady gait. WE was suspected because she also developed appetite loss for two weeks, and we could find no other laboratory findings to explain her unsteady gait. Our diagnosis was supported by abnormal serum thiamine and disappearance of the gait disturbance after intravenous thiamine administration. Case 2. A 50-year-old woman with breast carcinoma with bone metastasis developed an unsteady gait. WE was suspected because she also developed loss of appetite for two weeks, and no other laboratory findings could explain her unsteady gait. The diagnosis was supported by abnormal serum thiamine and disappearance of the gait disturbance after administration of intravenous thiamine.Significance of Results:Our report emphasizes the importance of being aware of WE, even when patients do not present with delirium. The presence of loss of appetite for more than two weeks may be the key to a diagnosis of WE.

Cocreating Meaning Through Expressive Writing and Reading for Cancer Caregivers

2019 ◽  
pp. 082585971987153 ◽  
Author(s):  
Yvonne W. Leung ◽  
Marta M. Maslej ◽  
Clara Ho ◽  
Shima Razavi ◽  
Paul Uy ◽  
...  
Keyword(s):  
Cognitive Processing ◽  
Expressive Writing ◽  
Emotional Processing ◽  
Social Connectedness ◽  
Descriptive Analysis ◽  
Cost Effective ◽  
Well Being ◽  
Perceived Usefulness ◽  
Patients With Cancer ◽  
Interpersonal Learning

Purpose: Caregivers of patients with cancer cope with socioemotional challenges, which can adversely affect their well-being. We developed an intervention, expressive writing and reading (EWR), to promote emotional processing and social connectedness among caregivers. In a single-arm pilot study, we assessed its feasibility and perceived usefulness. Methods: Caregivers participated in weekly 1.5-hour EWR workshops offered over 20 weeks. After 4 sessions, they completed semistructured interviews, which were analyzed using qualitative descriptive analysis. Findings: Of 65 caregivers approached, 25 were eligible, 18 consented, and 9 (50%) caregivers completed at least 4 workshops and the interview. Their responses revealed 3 themes: “inner processing,” “interpersonal learning,” and “enhanced processing and preparedness.” Perceived benefits of EWR included emotional and cognitive processing (individual and collaborative), learning from the emotions and experiences of other caregivers, and preparing for upcoming challenges. Conclusions: Expressive writing and reading can be a safe and cost-effective supportive intervention for caregivers of patients with cancer.

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