Human parathyroid hormone (1–34) accelerates the fracture healing process of woven to lamellar bone replacement and new cortical shell formation in rat femora

Bone ◽  
2005 ◽  
Vol 36 (4) ◽  
pp. 678-687 ◽  
Author(s):  
Satoshi Komatsubara ◽  
Satoshi Mori ◽  
Tasuku Mashiba ◽  
Kiichi Nonaka ◽  
Azusa Seki ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Fracture Healing ◽  
Healing Process ◽  
Shell Formation ◽  
Lamellar Bone ◽  
Human Parathyroid Hormone ◽  
Bone Replacement ◽  
Cortical Shell

Human parathyroid hormone (1–34) accelerates natural fracture healing process in the femoral osteotomy model of cynomolgus monkeys

Bone ◽  
2007 ◽  
Vol 40 (6) ◽  
pp. 1475-1482 ◽  
Author(s):  
Takeshi Manabe ◽  
Satoshi Mori ◽  
Tasuku Mashiba ◽  
Yoshio Kaji ◽  
Ken Iwata ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Fracture Healing ◽  
Healing Process ◽  
Femoral Osteotomy ◽  
Natural Fracture ◽  
Human Parathyroid Hormone ◽  
Cynomolgus Monkeys

Effect of human parathyroid hormone hPTH (1–34) applied at different regimes on fracture healing and muscle in ovariectomized and healthy rats

Bone ◽  
2010 ◽  
Vol 47 (3) ◽  
pp. 480-492 ◽  
Author(s):  
Marina Komrakova ◽  
Ewa K. Stuermer ◽  
Carsten Werner ◽  
Michael Wicke ◽  
Leila Kolios ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Fracture Healing ◽  
Human Parathyroid Hormone

scholarly journals Mechanisms for the Enhancement of Fracture Healing in Rats Treated With Intermittent Low-Dose Human Parathyroid Hormone (1-34)

2002 ◽  
Vol 17 (11) ◽  
pp. 2038-2047 ◽  
Author(s):  
Arata Nakajima ◽  
Naoshi Shimoji ◽  
Koji Shiomi ◽  
Sumito Shimizu ◽  
Hideshige Moriya ◽  
...  
Keyword(s):  
Parathyroid Hormone ◽  
Fracture Healing ◽  
Low Dose ◽  
Human Parathyroid Hormone

Backscattered Electron Imaging of the Calcified Tissues Present in Bone Healing

1998 ◽  
Vol 11 (02) ◽  
pp. 105-111 ◽  
Author(s):  
F. García ◽  
J. Camón ◽  
M. C. Manzanares ◽  
J. Franch
Keyword(s):  
Fracture Healing ◽  
Healing Process ◽  
Lamellar Bone ◽  
Backscattered Electron Imaging ◽  
Woven Bone ◽  
Chondroid Tissue ◽  
Calcified Cartilage ◽  
Backscattered Electron ◽  
Calcified Tissues ◽  
Electron Imaging

SummaryThe aspect of calcified tissues involved in fracture healing was studied by means of backscattered electron imaging. Bilateral transverse midshaft osteotomies were performed in the tibiae of 16 dogs. The osteotomies were reduced by means of a type II external skeletal fixator, and the clinical and radiographic course was assessed weekly until the moment of euthanasia, one, two, four and eight weeks after the operations. The osteotomized areas were removed and their structure examined in the scanning electron microscope, using backscattered electron images, to determine the general aspect of the extracellular matrix of the calcified tissues present. Four different tissues were observed: lamellar bone, woven bone, calcified cartilage and chondroid tissue. The backscattered electron contrast and fibre arrangement of the matrix, as well as the size and shape of the cellular lacunae, allow identification of the tissue. Chondroid tissue, which seems to have a leading role in the early phases of fracture healing, shows a characteristic pattern of a highly calcified and fibrous matrix with a large number of irregular and confluent cell lacunae.The morphological characteristics of the calcified tissues involved in fracture healing were studied by means of backscattered electron imaging. Lamellar bone, woven bone, calcified cartilage and chondroid tissue were the four calcified tissues observed during the healing process of canine midshaft tibial experimental fractures.

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