Methylenetetrahydrofolate reductase polymorphism (MTHFR C677T) and bone mineral density in Chinese men and women

Bone ◽  
2004 ◽  
Vol 35 (6) ◽  
pp. 1369-1374 ◽  
Author(s):  
M. Li ◽  
E.M.C. Lau ◽  
J. Woo
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Methylenetetrahydrofolate Reductase ◽  
Mthfr C677t ◽  
Mineral Density ◽  
Men And Women ◽  
Chinese Men

Association Between Calcium Regulatory Hormones and Other Factors and Bone Mineral Density in Elderly Chinese Men and Women

1994 ◽  
Vol 49 (4) ◽  
pp. M189-M194 ◽  
Author(s):  
J. Woo ◽  
E. Lau ◽  
R. Swaminathan ◽  
D. MacDonald ◽  
E. Chan ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Mineral Density ◽  
Men And Women ◽  
Chinese Men ◽  
Elderly Chinese

The C677T Polymorphism in the Methylenetetrahydrofolate Reductase (MTHFR)Gene Is an Important Determinant of Bone Mineral Density in Pediatric Acute Lymphoblastic Leukemia Patients.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4434-4434
Author(s):  
Robert D. van Beek ◽  
Sabine M.P.F. de Muinck Keizer-Schrama ◽  
Robert de Jonge ◽  
Rob Pieters ◽  
Marry M. van den Heuvel-Eibrink
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Bone Mineral ◽  
Methylenetetrahydrofolate Reductase ◽  
Lymphoblastic Leukemia ◽  
Mthfr C677t ◽  
Mthfr Gene ◽  
Healthy Controls ◽  
Mineral Density ◽  
One Year

Abstract Introduction: Pediatric acute lymphoblastic leukemia (ALL) and its treatment have adverse effects on growth, bone mineral density (BMD) and body composition. Methylenetetrahydrofolate reductase (MTHFR) is involved in folate and homocysteine metabolism. Several studies showed a higher incidence of methotrexate (MTX) related toxicity among carriers of polymorphisms in the (MTHFR) gene. Methods: We studied whether polymorphisms in the MTHFR gene influence the risk of therapy-induced side effects in pediatric ALL. C677T and A1298C polymorphisms in the MTHFR gene were studied in 83 pediatric ALL patients (47 male, 36 female) using real-time PCR and hybridization probes (LightCycler system). Mean age at diagnosis was 7.5 yr (1.5 – 16.8 yr). All patients were treated with a dexamethasone-based treatment protocol, without cranial irradiation. BMD of lumbar spine (LS) and total body (TB) and body composition were measured using DEXA-scan four times during therapy and once one year after therapy; results are compared with healthy age- and sex-matched controls and expressed as standard deviation scores (SDS). Bone mineral apparent density of the lumbar spine (BMAD) was calculated to correct for bone size. Results: In all patients, lean body mass (LBM) was already reduced at baseline and remained low during therapy, whereas percentage body fat increased during therapy. Height SDS was reduced during therapy and remained low during the first year after therapy. Carriers of the 677 T allele showed a reduced BMDLS as compared to healthy controls both at baseline (SDS −0.81; p<0.01) as well as during therapy and one year after cessation of therapy, whereas BMDTB and BMAD were normal at baseline in 677 T carriers as compared to healthy controls. After the first 32 weeks of therapy both BMDTB and BMAD were significantly reduced as compared to controls (SDS −0.90; p<0.001 and SDS −0.60; p<0.01 respectively). In carriers of the 677 T allele BMDTB remained low until the end of therapy and also one year after cessation of therapy as compared to healthy controls. In contrast, patients carrying the 677 CC wild-type variant had a normal BMD at baseline, which remained normal throughout therapy. The difference (diff.) between the carriers and non-carriers of the 677 T-allele was significant for BMDTB at baseline (diff. −0.83 SDS, p=0.05), after 32 weeks of therapy (diff. −0.94 SDS, p<0.01) and after 1 year of therapy (diff. −0.94 SDS, p<0.01).We did not find any effect of the MTHFR A1298C polymorphism on height, BMD, body composition. The MTHFR C677T and A1298C polymorphisms did not affect fracture rate. Conclusions: We identified the MTHFR C677T polymorphism as a determinant of bone mineral density in ALL patients especially in the first year of therapy, and as a risk factor for treatment-related loss of bone mass.

scholarly journals The Association of Lumbar Disc Herniation with Lumbar Volumetric Bone Mineral Density in a Cross-Sectional Chinese Study

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 938
Author(s):  
Jian Geng ◽  
Ling Wang ◽  
Qing Li ◽  
Pengju Huang ◽  
Yandong Liu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Lumbar Disc Herniation ◽  
Disc Herniation ◽  
Lumbar Disc ◽  
Magnetic Resonance Images ◽  
Volumetric Bone Mineral Density ◽  
Mineral Density ◽  
Men And Women ◽  
The Relationship

Little is known about the effect of lumbar intervertebral disc herniation (LDH) on lumbar bone mineral density (BMD), and few previous studies have used quantitative computed tomography (QCT) to assess whether the staging of LDH correlates with lumbar vertebral trabecular volumetric bone mineral density (Trab.vBMD). To explore the relationship between lumbar Trab.vBMD and LDH, seven hundred and fifty-four healthy participants aged 20–60 years were enrolled in the study from an ongoing study on the degeneration of the spine and knee between June 2014 and 2017. QCT was used to measure L2–4 Trab.vBMD and lumbar spine magnetic resonance images (MRI) were performed to assess the incidence of disc herniation. After 9 exclusions, a total of 322 men and 423 women remained. The men and women were divided into younger (age 20–39 years) and older (age 40–60 years) groups and further into those without LDH, with a single LDH segment, and with ≥2 segments. Covariance analysis was used to adjust for the effects of age, BMI, waistline, and hipline on the relationship between Trab.vBMD and LDH. Forty-one younger men (25.0%) and 59 older men (37.3%) had at least one LDH segment. Amongst the women, the numbers were 46 (22.5%) and 80 (36.4%), respectively. Although there were differences in the characteristics data between men and women, the difference in Trab.vBMD between those without LDH and those with single and ≥2 segments was not statistically significant (p > 0.05). These results remained not statistically significant after further adjusting for covariates (p > 0.05). No associations between lumbar disc herniation and vertebral trabecular volumetric bone mineral density were observed in either men or women.

scholarly journals Determinants of Bone Mineral Density in Older Men and Women: Body Composition as Mediator

2001 ◽  
Vol 16 (11) ◽  
pp. 2142-2151 ◽  
Author(s):  
S. M. F. Pluijm ◽  
M. Visser ◽  
J. H. Smit ◽  
C. Popp-Snijders ◽  
J. C. Roos ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Bone Mineral ◽  
Older Men ◽  
Mineral Density ◽  
Men And Women ◽  
Older Men And Women
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