Osteogenic and chondrogenic differentiation of embryonic stem cells in response to specific growth factors

Bone ◽  
2005 ◽  
Vol 36 (5) ◽  
pp. 758-769 ◽  
Author(s):  
J KAWAGUCHI ◽  
P MEE ◽  
A SMITH
Keyword(s):  
Stem Cells ◽  
Growth Factors ◽  
Embryonic Stem Cells ◽  
Chondrogenic Differentiation ◽  
Specific Growth ◽  
Embryonic Stem

Effects of Three-Dimensional Culture and Growth Factors on the Chondrogenic Differentiation of Murine Embryonic Stem Cells

Stem Cells ◽  
2006 ◽  
Vol 24 (2) ◽  
pp. 284-291 ◽  
Author(s):  
Nathaniel S. Hwang ◽  
Myoung Sook Kim ◽  
Somponnat Sampattavanich ◽  
Jin Hyen Baek ◽  
Zijun Zhang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factors ◽  
Embryonic Stem Cells ◽  
Chondrogenic Differentiation ◽  
Three Dimensional ◽  
Embryonic Stem ◽  
Murine Embryonic Stem Cells ◽  
Three Dimensional Culture

Chondrogenic differentiation of mouse embryonic stem cells promoted by mature chondrocytes

2008 ◽  
Vol 51 (9) ◽  
pp. 774-778 ◽  
Author(s):  
Feng Xie ◽  
WenJie Zhang ◽  
FanFan Chen ◽  
GuangDong Zhou ◽  
Lei Cui ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Chondrogenic Differentiation ◽  
Embryonic Stem ◽  
Mouse Embryonic Stem Cells

Using embryonic stem cells to understand how glycosaminoglycans regulate differentiation

2014 ◽  
Vol 42 (3) ◽  
pp. 689-695 ◽  
Author(s):  
Rebecca J. Holley ◽  
Kate A. Meade ◽  
Catherine L.R. Merry
Keyword(s):  
Stem Cells ◽  
Growth Factors ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cost Effective ◽  
Cell Types ◽  
Signalling Pathways ◽  
Stem Cell Maintenance ◽  
Morphogenetic Protein ◽  
High Concentrations

Differentiation and subsequent specialization of every cell within an organism is an intricate interwoven process. A complex network of signalling pathways eventually leads to the specification of a multitude of different cell types able to function co-operatively. HS (heparan sulfate) is a highly sulfated linear polysaccharide that resides at the pericellular cell–matrix interface where it dictates the binding and activity of a large number of proteins, including growth factors and morphogens such as members of the FGF (fibroblast growth factor) and BMP (bone morphogenetic protein) families. Embryonic stem cells derived from mice with mutations in components of the HS biosynthetic pathway provide an opportunity to dissect the contribution of HS to signalling pathways critical for regulating stem cell maintenance and differentiation. In addition to improving our understanding of signalling mechanisms, this knowledge enables the selection of exogenous HS saccharides to improve the efficiency and selectivity of directed differentiation protocols, offering a cost-effective alternative to high concentrations of expensive growth factors to drive differentiation towards a particular therapeutically relevant cell type.

scholarly journals Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells

2000 ◽  
Vol 97 (21) ◽  
pp. 11307-11312 ◽  
Author(s):  
M. Schuldiner ◽  
O. Yanuka ◽  
J. Itskovitz-Eldor ◽  
D. A. Melton ◽  
N. Benvenisty
Keyword(s):  
Stem Cells ◽  
Growth Factors ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem

Chondrogenic Differentiation of Human Embryonic Stem Cells: The Effect of the Micro-Environment

2006 ◽  
Vol 12 (6) ◽  
pp. 1687-1697 ◽  
Author(s):  
Archana Vats ◽  
Robert C. Bielby ◽  
Neil Tolley ◽  
Sally C. Dickinson ◽  
Aldo R. Boccaccini ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Chondrogenic Differentiation ◽  
Embryonic Stem
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