Low-level lifetime exposure to cadmium decreases skeletal mineralization and enhances bone loss in aged rats

Bone ◽  
2004 ◽  
Vol 35 (5) ◽  
pp. 1180-1191 ◽  
Author(s):  
M.M. Brzóska ◽  
J. Moniuszko-Jakoniuk
Keyword(s):  
Bone Loss ◽  
Aged Rats ◽  
Level Lifetime ◽  
Low Level ◽  
Lifetime Exposure ◽  
Skeletal Mineralization

scholarly journals Role of Secreted Frizzled-Related Protein 1 and Tumor Necrosis Factor-α (TNF-α) in Bone Loss of Patients with Rheumatoid Arthritis

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Andi Raga Ginting ◽  
Rudy Hidayat ◽  
Sumariyono Sumariyono ◽  
Sukamto Koesnoe
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Loss ◽  
Cross Sectional Study ◽  
Related Protein ◽  
Cross Sectional ◽  
Low Level ◽  
Female Patients ◽  
Premenopausal Female ◽  
High Level ◽  
Turn Over

Bone loss is one of the emerging extra-articular manifestations of rheumatoid arthritis. TNF-α is the main inflammatory cytokine that can directly increase bone resorption. However, its role in bone formation is still unknown, especially related to secreted frizzled-related protein 1 (SFRP-1), an osteoblast inhibitor. This study examines the correlation between TNF-α and SFRP-1, with a bone turn over marker (CTX and P1NP). This is a cross-sectional study with 38 subjects of premenopausal female patients with RA. This study found that 60.6% of the patients were in remission or low disease activity. The median of TNF-α was 10.6 pg/mL, mean of SFRP-1 was 9.29 ng/mL, mean of CTX was 2.74 ng/mL, and the median of P1NP was 34.04 pg/ml. There is positive correlation between TNF-α and P1NP (r=0.363, p=0.026), also between SFRP-1 and P1NP (r=0.341; p=0.036). A low level of TNF-𝛼, high level of SFRP-1, high level of CTX, and low level of P1NP in this study indicate a high bone turn over process, with dominant resorption activity in premenopausal female patients with RA.

scholarly journals Improvement of bone properties and enhancement of mineralization by ethanol extract of Fructus Ligustri Lucidi

2008 ◽  
Vol 99 (3) ◽  
pp. 494-502 ◽  
Author(s):  
Yan Zhang ◽  
Ping-Chung Leung ◽  
Chun-Tao Che ◽  
Hung-Kay Chow ◽  
Chun-Fu Wu ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Mineral ◽  
Sham Operation ◽  
Dependent Manner ◽  
Aged Rats ◽  
Mineral Density ◽  
Fructus Ligustri Lucidi ◽  
Bone Properties ◽  
Ovx Rats ◽  
Umr 106

Fructus Ligustri Lucidi (FLL), a kidney-tonifying Chinese herb, was shown to regulate Ca balance in ovariectomized (OVX) rats in our previous study. This study investigated whether it could improve bone properties in aged normal and OVX rats and increase osteoblastic differentiation in rat osteoblast-like UMR-106 cells. Ten-month-old aged rats underwent sham-operation or ovariectomy, were orally administered with FLL extracts or its vehicle and fed with diets containing different levels of Ca (LCD, 0·1 % Ca; MCD, 0·6 % Ca; HCD, 1·2 % Ca) for 12 weeks. Ovariectomy induced bone loss at multiple-sites of both tibia and femur in all rats being studied. FLL extract increased bone mineral density and bone mineral content at both tibial and femoral diaphysis as well as the lumbar vertebra (LV-2) in rats fed either LCD or MCD. In addition, FLL increased biomechanical strength of the tibial diaphysis in these rats. Combination of FLL and high-Ca diet significantly improved bone mass of cortical and trabecular bone at appendicular bones and LV-2 and decreased bone loss associated with ovarietomy and low-Ca feeding. Treatment of UMR-106 cells with FLL extracts accelerated the formation of calcified matrix and increased extracellular Ca and P depositions in time- and dose-dependent manner. The level of mineralization reached a maximum by 6 d incubation at the dosage of 10 μg FLL extract/ml. Our study indicated that FLL extract could improve bone properties in aged rats possibly via its direct action on osteoblastic cells by enhancement of the mineralization process.

Low-level caloric restriction rescues proteasome activity and Hsc70 level in liver of aged rats

2007 ◽  
Vol 9 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Mara A. Bonelli ◽  
Silvia Desenzani ◽  
Gabriella Cavallini ◽  
Alessio Donati ◽  
Antonello A. Romani ◽  
...  
Keyword(s):  
Caloric Restriction ◽  
Proteasome Activity ◽  
Aged Rats ◽  
Low Level

scholarly journals Low-Frequency Electrical Stimulation of Denervated Skeletal Muscle Retards Muscle and Trabecular Bone Loss in Aged Rats

2019 ◽  
Vol 16 (6) ◽  
pp. 822-830
Author(s):  
Hiroyuki Tamaki ◽  
Kengo Yotani ◽  
Futoshi Ogita ◽  
Keishi Hayao ◽  
Hikari Kirimto ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Electrical Stimulation ◽  
Bone Loss ◽  
Trabecular Bone ◽  
Low Frequency ◽  
Aged Rats ◽  
Trabecular Bone Loss ◽  
Stimulation Of

scholarly journals Cycloastragenol prevents age-related bone loss: Evidence in d-galactose-treated and aged rats

2020 ◽  
Vol 128 ◽  
pp. 110304
Author(s):  
Yongjie Yu ◽  
Jingkai Wu ◽  
Jin Li ◽  
Yanzhi Liu ◽  
Xiaoyan Zheng ◽  
...  
Keyword(s):  
Bone Loss ◽  
Aged Rats ◽  
Age Related
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