Vitamin D deficiency and secondary hyperparathyroidism and the association with bone mineral density in persons with Pakistani and Norwegian background living in Oslo, Norway

Bone ◽  
2004 ◽  
Vol 35 (2) ◽  
pp. 412-417 ◽  
Author(s):  
Haakon E Meyer ◽  
Jan A Falch ◽  
Anne Johanne Søgaard ◽  
Egil Haug
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Vitamin D deficiency, secondary hyperparathyroidism and bone mineral density in Pakistani and Norwegians living in Oslo, Norway / Vitamin D-mangel, sekundær hyperparathyroidisme og bentetthet hos pakistanere og nordmenn bosatt i Oslo

2009 ◽  
Vol 16 (2) ◽  
Author(s):  
Kari Alvær ◽  
Kristin Holvik ◽  
Anne Johanne Søgaard ◽  
Jan A. Falch ◽  
Haakon E. Meyer
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Bone Mineral ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Men And Women ◽  
Skeletal Size ◽  
Pakistani Women

<p>We studied the prevalence of vitamin D deficiency and bone mineral density in Norwegian born and Pakistani born men and women living in Oslo. We measured 25-hydroxyvitamin D, iPTH and ionized calcium in serum and bone mineral density (BMD) at the forearm with single energy X-ray absorptiometry. 1386 persons born in Norway and 177 persons born in Pakistan participated. Among the Pakistani born 9% of the men and 21% of women were seriously vitamin D deficient (25(OH)D < 12.5 nmol/l). None of the Norwegian born had such low levels of vitamin D. While 86% of the Norwegians were vitamin D sufficient (25(OH)D ! 50 nmol/l), only 8% of Pakistani men and 10% of Pakistani women had a sufficient vitamin D status. The prevalence of secondary hyperparathyroidism was four times higher in Pakistani women and five times higher in Pakistani men compared to their Norwegian counterparts. Unadjusted bone mineral density was not different between the two ethnic groups, but in the multivariate analysis BMD was 0.020 g/cm<sup>2</sup> (95% CI: 0.007–0.033) higher in Pakistani men than in Norwegian men. We also found 5-8% higher bone mineral density in Pakistani men and women when we controlled for different skeletal size. While BMD was lower in Norwegian women with, compared to Norwegian women without, secondary hyperparathyroidsm (–0.027 g/cm<sup>2</sup>, p = 0.019), there was no difference in BMD between Pakistani women with and without secondary hyperparathyroidsm</p><p>Vi har sett på prevalens av vitamin D-mangel og bentetthet hos norskfødte og pakistanskfødte menn og kvinner i den populasjonsbaserte Helseundersøkelsen i Oslo 2000-2001. Det ble målt 25-hydroksyvitamin D, iPTH og ionisert kalsium i serum, og benmineraltetthet (BMD) ble målt i underarmen. Totalt deltok 1386 personer født i Norge og 177 personer født i Pakistan i aldersgruppen 30-75 år. Blant pakistanske menn og kvinner hadde henholdsvis 8% og 10% tilfredsstillende vitamin D-status (25(OH)D ! 50 nmol/l), mens 9% og 21% hadde alvorlig vitamin D-mangel (25(OH)D < 12,5 nmol/l). Blant personer født i Norge hadde 86% tilfredsstillende vitamin D-status og ingen hadde alvorlig vitamin D-mangel. Prevalensen av sekundær hyperparatyreoidisme var 4 ganger høyere hos pakistanske kvinner og 5 ganger høyere hos pakistanske menn enn hos norske kvinner og menn. Ujustert benmineraltetthet var ikke forskjellig hos pakistanere og nordmenn, men justert for andre risikofaktorer fant vi 0,020 g/cm<sup>2</sup> (95% CI: 0,007–0,033) høyere BMD hos pakistanske menn enn hos norske menn. Tilsvarende fant vi opptil 5-8% høyere bentetthet hos pakistanere enn nordmenn når vi korrigerte for ulik skjelettstørrelse i de to gruppene. Videre fant vi en positiv sammenheng mellom 25(OH)D og BMD hos norske kvinner (r = 0,11, p = 0,019) og norske menn (r = 0,16, p = 0,002). En svakere sammenheng ble funnet hos pakistanske menn, mens vi ikke fant noen assosiasjon hos pakistanske kvinner. Tilsvarende hadde de norske kvinnene med sekundær hyperparatyreoidisme lavere BMD enn norske kvinner uten sekundær hyperparatyreoidisme (–0,027 g/cm<sup>2</sup>, p = 0,019). Samme tendens ble også observert for både pakistanske og norske menn, men ikke for pakistanske kvinner.</p>

Influence of vitamin D deficiency on the bone mineral density in schoolchildren

2015 ◽  
Author(s):  
Vladyslav Povoroznyuk ◽  
Nataliya Balatska ◽  
Olga Tyazhka ◽  
Tetiana Budnik ◽  
Inga Kubey ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals P1621VITAMIN D SUPPLEMENTATION: CHANGES IN BONE MINERAL DENSITY IN KIDNEY TRANSPLANT PATIENTS WITH LONG TERM DURATION OF THE GRAFT

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Yuri Battaglia ◽  
Michele Provenzano ◽  
Francesco Tondolo ◽  
Antonio Bellasi ◽  
Pasquale Esposito ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Kidney Transplant ◽  
Bone Mineral ◽  
Categorical Variables ◽  
Z Score ◽  
Mineral Density ◽  
T Score

Abstract Background and Aims In the medical literature, several studies have linked bone mineral density (BMD) with vitamin D deficiency in kidney transplant patients (KTRs). However, in spite of the fact that ergocalciferol, cholecalciferol and calcifediol reduce parathyroid hormone (PTH) and improves calcium levels, their effects on the bone mineral density (BMD) in KTRs remain undefined. In consideration of the lack of data available, we aim at investigating the effect of inactive form of vitamin D supplementation on the BMD over a follow-up period up to 2 year, in a real-life cohort of long-term kidney transplant(KT). Method This study was carried out in KTRs who were followed up in a Nephrology Unit. Exclusion criteria were parathyroidectomy, therapy with bisphosphonate, previous history of bone fractures. Demographic, clinical and immunosuppressive agents were collected. Based on 25-OH-D levels, KTRs were classified as suffering from deficiency (&lt; 30 ng/mL). BMD was evaluated at lumbar vertebral bodies (LV) and right femoral hip (FH) by a single operator, using a standard dual energy X-ray absorptiometry. According to WHO criteria, results were expressed as T-score (standard deviation [SD] relative to young healthy adults), and Z-score (SD relative to age-matched controls). Osteoporosis and osteopenia were defined as T score ≤ −2.5 SD and T score &lt; −1 and &gt; −2.5 SD, respectively. Laboratory data, 25-OH-D, and BMD were measured at baseline and after 24 months of supplementation therapy. Vitamin D deficiency was corrected using standard treatment strategy recommended for general population. Continuous variables were expressed as mean ± SD whereas categorical variables as percentage. The Student’s t test and chi-square test were used to compare to compare continuous and categorical variables, respectively. For before and after comparisons of continuous variables, the paired t-test or one-sample Wilcoxon signed rank test were used based on variable’s distribution. Results Data pertaining to 111 out of 133 consecutive outpatients were collected, of whom most were males (69.4%), no-smokers (89.1%) and treated with glucocorticoids (84%). The mean age was 53.9±11.6 years and months after transplant was 161.6±128.3. No statistical differences were found among patients with normal BMD, osteopenia or osteoporosis at LV and FH in terms of age at transplant, gender distribution, time on dialysis, BMI and eGFR, serum calcium, serum phosphate, 25-OH-D and iPTH. At baseline, 25-OH-D was 13.9±7.2 ng/ml and the prevalence of osteopenia/osteoporosis was 40.9% (T-Score -1.69±0.37; Z-score -1.16±1.09) and 21.8 % (T-Score -3.15±0.50; Z-score -2.27±0.58) at LV; 55.3 % (T-Score -1.8±0.46; Z-score -0.84±0.633) and 14 % (T-Score -2.83±0.39; Z-score -1.65±0.49) at FH. After 27.6±3.7 months of therapy with cholecalciferol at mean dose of 13.396±7.537 UI at week, 25-OH-D values increased to 29.4±9.4 ng/ml (p&lt;0.0001) while no statistically significant changes were found in Z-score and T-score at both sites, except for a mild improvement in lumbar vertebral Z-score, reaching −0.82± 0.7 (p = 0.06) in KTRs with osteopenia Conclusion Our study showed BMD remained stable after up to 2 years of inactive vitamin D therapy in long-term kidney transplant with vitamin D deficiency. A mild increase in Z-score was observed in the L-spine. Further designated studies should be conducted to demonstrate the effect of vitamin D on BMD.

scholarly journals Osteoporosis in Healthy South Indian Males and the Influence of Life Style Factors and Vitamin D Status on Bone Mineral Density

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Sahana Shetty ◽  
Nitin Kapoor ◽  
Dukhabandhu Naik ◽  
Hesarghatta Shyamasunder Asha ◽  
Suresh Prabu ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bone Mineral Density ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Bone Mineral ◽  
Life Style ◽  
Mineral Density ◽  
South Indian ◽  
Indian Men ◽  
Prevalence Of Osteoporosis

Objective. To study the prevalence of osteoporosis and vitamin D deficiency in healthy men and to explore the influence of various life style factors on bone mineral density (BMD) and also to look at number of subjects warranting treatment.Methods. Ambulatory south Indian men aged above 50 were recruited by cluster random sampling. The physical activity, risk factors in the FRAX tool, BMD, vitamin D, and PTH were assessed. The number of people needing treatment was calculated, which included subjects with osteoporosis and osteopenia with 10-year probability of major osteoporotic fracture >20 percent and hip fracture >3 percent in FRAX India.Results. A total of 252 men with a mean age of 58 years were studied. The prevalence of osteoporosis and osteopenia at any one site was 20% (50/252) and 58%, respectively. Vitamin D deficiency (<20 ng/dL) was seen in 53%. On multiple logistic regression, BMI (OR 0.3;Pvalue = 0.04) and physical activity (OR 0.4;Pvalue < 0.001) had protective effect on BMD. Twenty-five percent warranted treatment.Conclusions. A significantly large proportion of south Indian men had osteoporosis and vitamin D deficiency. Further interventional studies are needed to look at reduction in end points like fractures in these subjects.

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