The flurbiprofen derivatives HCT1026 and HCT1027 inhibit bone resorption by a mechanism independent of COX inhibition and nitric oxide production

Bone ◽  
2004 ◽  
Vol 35 (3) ◽  
pp. 636-643 ◽  
Author(s):  
A.I. Idris ◽  
P. Del Soldato ◽  
S.H. Ralston ◽  
R.J. van't Hof
Keyword(s):  
Nitric Oxide ◽  
Bone Resorption ◽  
Nitric Oxide Production ◽  
Inhibit Bone Resorption ◽  
Oxide Production

scholarly journals Host defense peptides clavanins A and MO reduce in vitro osteoclastogenesis

2021 ◽  
Vol 20 ◽  
pp. e211512
Author(s):  
Ingrid Aquino Amorim ◽  
Stella Maris de Freitas Lima ◽  
Ana Paula de Castro Cantuária ◽  
Mirna de Souza Freire ◽  
Jeeser Alves de Almeida ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Bone Resorption ◽  
Calcium Hydroxide ◽  
Host Defense ◽  
Nitric Oxide Production ◽  
Cellular Viability ◽  
Host Defense Peptides ◽  
Oxide Production ◽  
Defense Peptides

Aim: Several systemic diseases, such as periodontitis and apical periodontitis, can cause extensive bone resorption. Host defense peptides may have the potential for the development of novel therapies for the bone resorption process. This study evaluated the potential of host defense peptides clavanins A, MO, and LL-37 in in vitro osteoclastogenesis. Methods: RAW 264.7 cultures were stimulated with recombinant of receptor activator of nuclear factor kappa B ligand in the presence of different tested concentrations of host defense peptides, besides calcium hydroxide and doxycycline. Cellular viability, nitric oxide production, and a number of differentiated osteoclast-like cells were also evaluated. Results: Results showed that none of the substances were cytotoxic, except for 128 μg.mL-1 of doxycycline after 3 days. Host defense peptides, calcium hydroxide, and doxycycline did not interfere in nitric oxide production or downregulated it. An exception was observed in the presence of 2 μg.mL-1 of doxycycline, in which nitric oxide production was up-regulated. All host defense peptides were capable of reducing osteoclast-like cell differentiation. Conclusion: Host defense peptides clavanins A and MO demonstrated to be potential suppressors of osteoclastogenesis in vitro without interfering in cellular viability and nitric oxide production. These promising results need to be further analyzed in in vivo models of bone resorption.

Increased bone resorption in the critically ill: Association with sepsis and increased nitric oxide production

2002 ◽  
Vol 30 (4) ◽  
pp. 837-840 ◽  
Author(s):  
Lorna M. Smith ◽  
Brian Cuthbertson ◽  
John Harvie ◽  
Nigel Webster ◽  
Simon Robins ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Bone Resorption ◽  
Critically Ill ◽  
Nitric Oxide Production ◽  
Oxide Production

502: Pressure Induces Nitric Oxide Production by Human Ureteral Cells in Vitro

2005 ◽  
Vol 173 (4S) ◽  
pp. 137-137
Author(s):  
Michael M. Ohebshalom ◽  
Stella K. Maeng ◽  
Jie Chen ◽  
Dix P. Poppas ◽  
Diane Felsen
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Production ◽  
Oxide Production

Effect of Nelumbo nucifera on nitric oxide production and co-stimulatory molecules

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
D Mukherjee ◽  
TN Khatua ◽  
A Biswas ◽  
T Biswas ◽  
BP Saha ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nelumbo Nucifera ◽  
Nitric Oxide Production ◽  
Oxide Production
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